STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PG_0223Exonuclease; Similar to GB:M24777, SP:P06994, GB:M10417, GB:U04742, GB:U04743, GB:U04744, GB:U04745, GB:U04746, GB:U04747, GB:U04748, GB:U04749, GB:U04750, GB:U04751, GB:U04752, GB:U04753, GB:U04754, GB:U04755, GB:U04756, GB:U04757, GB:U04758, GB:U04759, GB:U04760, GB:U04770, GB:Y00129, PID:440001, PID:440003, PID:440005, PID:440009, PID:440011, PID:440013, PID:440017, PID:440019, PID:440021, PID:440023, PID:440025, PID:440027, PID:440029, PID:440031, PID:440033, PID:440035, PID:440037, PID:440057, PID:450385, PID:146799, PID:41989, PID:606175, GB:U00096, PID:1789632, PID:2289251, PID: [...] (163 aa)    
Predicted Functional Partners:
dnaE
DNA polymerase III, alpha subunit; Similar to SP:P12743; identified by sequence similarity; putative.
   
 0.953
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.953
dnaX
DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.951
PG_0932
DNA polymerase III, delta prime subunit, putative.
   
 0.944
PG_0949
Conserved hypothetical protein; Similar to GB:X59739, GB:X59738, GB:X59740, SP:P08048, SP:P17010, PID:340434, PID:38020, PID:38022, and PID:38024; identified by sequence similarity; putative.
    
 0.939
PG_1852
Exonuclease; Similar to GB:X52592, and PID:46994; identified by sequence similarity; putative.
     
  0.900
PG_0224
Conserved hypothetical protein; Similar to GB:Z31385, PID:619427, PID:619615, PID:619616, PID:861002, PID:940532, GB:Z31385, PID:619427, PID:619615, PID:619616, PID:861002, and PID:940532; identified by sequence similarity; putative.
       0.773
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
      
 0.541
polA
DNA polymerase type I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.513
PG_0225
ISPg4, transposase.
       0.429
Your Current Organism:
Porphyromonas gingivalis
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.