Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RB100922-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; Best DB hits: BLAST: ref:XP_002773.1; CGI-105 protein [Homo sapiens]; E=4e-56 gb:AAD34100.1; AF151863_1 (AF151863) CGI-105 protein [Homo; E=6e-56 gb:AAF55945.1; (AE003737) CG6028 gene product [Drosophila; E=3e-54 COG: BH2000; COG0179 2-keto-4-pentenoate; E=1e-45 PFAM: PF01557; Fumarylacetoacetate (FAA) hydro; E=5.1e-83. (342 aa)    
Predicted Functional Partners:
RB10089
Conserved hypothetical protein; Best DB hits: BLAST: embl:CAB66289.1; (AL136519) hypothetical protein SCC57A.21c; E=3e-19 swissprot:P42419; IOLI_BACSU IOLI PROTEIN ----- pir: A69646; E=4e-07 ddbj:BAB06034.1; (AP001515) myo-inositol catabolism [Bacillus; E=1e-06 COG: BS_iolI; COG1082 Predicted endonucleases; E=4e-08 PFAM: PF01542; Hepatitis C virus core protei; E=0.23.
       0.533
hpaG
Probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomaerase; PMID: 8550403 best DB hits: BLAST: embl:CAC24092.1; (AL512982) hypothetical [Sulfolobus; E=1e-48 embl:CAB55723.1; (AL117387) hypothetical protein SCF41.20c; E=3e-18 pir:T45421; probable 2-hydroxyhepta-2,4-diene-1,7-dioate isomaerase; E=1e-10 COG: Rv2993c; COG0179 2-keto-4-pentenoate; E=2e-11 PFAM: PF01557; Fumarylacetoacetate (FAA) hydro; E=0.0074.
 
     0.496
RB6500
Mycocerosate synthase; PMID: 3880746 best DB hits: BLAST: pir:S72705; mycocerosate synthase (EC 2.3.1.111) - Mycobacterium; E=0.0 pir:H70819; probable polyketide synthase - Mycobacterium tuberculosis; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=1e-180 COG: PA2402_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=4e-99 BS_ppsD_3; COG1020 Non-ribosomal peptide synthetase modules and; E=4e-92 PA2424_2; COG1020 Non-ribosomal peptide synthetase modules and related; E=1e-91 PFAM: PF00108; Thiolase, N-terminal domain; E=2.7e-06 PF00109; Beta-keto [...]
  
 
 0.482
gltB
Glutamate synthase [NADPH] large chain; PMID: 2643092 PMID: 3326786 best DB hits: BLAST: swissprot:Q06434; GLSF_ANTSP FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE; E=0.0 swissprot:P23225; GLSF_MAIZE FERREDOXIN-DEPENDENT GLUTAMATE; E=0.0 swissprot:Q03460; GLSN_MEDSA GLUTAMATE SYNTHASE [NADH], CHLOROPLAST; E=0.0 COG: sll1502_2; COG0069 Glutamate synthetase domain 2; E=0.0 sll1502_1; COG0067 Glutamate synthetase domain 1; E=1e-118 PFAM: PF01645; Conserved region in glutamate; E=5.5e-235 PF01493; Domain of unknown function DU; E=4.2e-95.
     
 0.454
RB6394
Probable 2-hydroxyacid dehydrogenase; PMID: 10984043 best DB hits: BLAST: gb:AAH00605.1; AAH00605 (BC000605) glyoxylate; E=1e-66 ref:XP_005487.2; glyoxylate reductasehydroxypyruvate reductase; E=1e-66 gb:AAF51963.1; (AE003602) CG1236 gene product [Drosophila; E=7e-61 COG: APE1831; COG1052 Lactate dehydrogenase and related dehydrogenases; E=2e-60 PAB0514; COG0111 Phosphoglycerate dehydrogenase and related; E=3e-44 YNL274c; COG1052 Lactate dehydrogenase and related dehydrogenases; E=3e-34 PFAM: PF00389; D-isomer specific 2-hydroxyacid; E=2.4e-06 PF02826; D-isomer specific 2-hydroxyacid; [...]
 
    0.428
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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