STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaNDNA polymerase III, beta chain; PMID: 2540413 best DB hits: BLAST: swissprot:P13455; DP3B_PSEPU DNA POLYMERASE III, BETA CHAIN; E=1e-31 pir:C81713; DNA polymerase III, beta chain TC0347 [imported] -; E=1e-29 pir:E71559; probable DNA pol III (beta chain) - Chlamydia; E=1e-29 COG: CT075; COG0592 DNA polymerase III beta subunit; E=1e-30 PFAM: PF00712; DNA polymerase III beta subun; E=7.1e-16 PF02767; DNA polymerase III beta subun; E=2.4e-12 PF02768; DNA polymerase III beta subun; E=1e-10. (444 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.997
dnaQ
Best DB hits: BLAST: swissprot:P13267; DPO3_BACSU DNA POLYMERASE III, ALPHA CHAIN; E=8e-09 pir:JH0232; DNA-directed DNA polymerase (EC 2.7.7.7) III alpha chain; E=8e-09 gb:AAA22666.1; (M22996) polymerase III [Bacillus subtilis]; E=9e-09 COG: BS_polC; COG2176 DNA polymerase III alpha subunit, the Gram-positive; E=8e-10 Rv2191_1; COG0847 DNA polymerase III epsilon subunit (3'-5'; E=2e-09 TM0576; COG2176 DNA polymerase III alpha subunit, the Gram-positive; E=6e-08 PFAM: PF00929; Exonuclease; E=1.2e-18 PF00533; BRCA1 C Terminus (BRCT) domain; E=2.4e-09.
  
 0.992
RB2871
Hypothetical protein; PMID: 12004073.
 
 
 0.992
dnaE-2
DNA polymerase III alpha subunit; PMID: 3316192 PMID: 3316192 best DB hits: BLAST: swissprot:O83675; DP3A_TREPA DNA POLYMERASE III, ALPHA CHAIN -----; E=0.0 gb:AAD44403.1; (AF062920) DNA polymerase III [Thermus aquaticus]; E=0.0 swissprot:O67125; DP3A_AQUAE DNA POLYMERASE III, ALPHA CHAIN -----; E=0.0 COG: TP0669; COG0587 DNA polymerase III alpha subunit; E=0.0 PFAM: PF02231; PHP domain N-terminal region; E=5.8e-32 PF02811; PHP domain C-terminal region; E=2e-36 PF01336; OB-fold nucleic acid binding domain; E=1.4e-08.
  
 
 0.990
holB
Best DB hits: BLAST: pir:C75278; DNA polymerase III, taugamma subunit - Deinococcus; E=2e-23 gb:AAB82595.1; (AF025391) DNA polymerase III holoenzyme tau; E=4e-22 pir:A70460; DNA polymerase III gamma subunit - Aquifex aeolicus; E=9e-21 COG: DR2410; COG2812 DNA polymerase III, gamma/tau subunits; E=2e-24 NMB0769; COG0470 ATPase involved in DNA replication; E=1e-19 Cj1157; COG2812 DNA polymerase III, gamma/tau subunits; E=4e-18 PFAM: PF00448; SRP54-type protein, GTPase domain; E=0.64 PF00004; ATPase family associated with vario; E=0.0033.
   
 0.989
dnaX
DNA polymerase III gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.989
dnaA-2
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 0.980
dnlI
Thermostable DNA ligase; PMID: 8843436 best DB hits: BLAST: embl:CAC01484.1; (AL391017) putative DNA ligase [Streptomyces; E=5e-32 swissprot:P56709; DNLI_PYRFU THERMOSTABLE DNA LIGASE; E=4e-30 embl:CAC21199.1; (AJ133713) DNA ligase [Thermococcus fumicolans]; E=4e-29 COG: VNG0881G; COG1793 ATP-dependent DNA ligase; E=5e-29 PFAM: PF01068; DNA ligase; E=1.2e-28.
   
 0.978
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 0.975
mutS
DNA mismatch repair protein MUTS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
   
 0.972
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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