Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folD | glyA | RB7468 | RB6215 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.989 |
| folD | pur3 | RB7468 | RB7260 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; PMID: 95004650 best DB hits: BLAST: embl:CAA52779.2; (X74767) phosphoribosylglycinamide; E=1e-25 swissprot:P52422; PUR3_ARATH PHOSPHORIBOSYLGLYCINAMIDE; E=1e-25 pir:T11574; phosphoribosylglycinamide formyltransferase (EC 2.1.2.2); E=2e-25 COG: aq_857; COG0299 Folate-dependent phosphoribosylglycinamide; E=1e-23 VC1992; COG0788 Formyltetrahydrofolate hydrolase; E=9e-12 Cj0187c; COG0299 Folate-dependent phosphoribosylglycinamide; E=4e-11 PFAM: PF00551; Formyl transferase; E=2.9e-41. | 0.955 |
| folD | purA | RB7468 | RB12924 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.795 |
| folD | purB | RB7468 | RB8343 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.883 |
| folD | purD | RB7468 | RB6616 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylamine-glycine ligase; PMID: 8299947 best DB hits: BLAST: pir:T46882; phosphoribosylamine--glycine ligase (EC 6.3.4.13); E=1e-108 pir:I67805; purine synthesis multifunctional protein - mouse -----; E=1e-108 gb:AAC53250.1; (U20892) glycinamide ribonucleotide synthetase; E=1e-107 COG: BH0634; COG0151 Phosphoribosylamine-glycine ligase; E=1e-108 PFAM: PF02844; Phosphoribosylglycinamide syn; E=6.3e-55 PF02842; Phosphoribosylglycinamide syn; E=2.5e-30 PF01837; Domain of unknown function DU; E=0.23. | 0.953 |
| folD | purE | RB7468 | RB6135 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazole carboxylase catalytic subunit (air carboxylase) (airc); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.596 |
| folD | purF | RB7468 | RB5050 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase [precursor]; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.628 |
| folD | purH | RB7468 | RB10113 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113. | 0.977 |
| folD | purL | RB7468 | RB5395 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.768 |
| folD | purM | RB7468 | RB12745 | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine cyclo-ligase; PMID: 3015935 PMID: 3530323 best DB hits: BLAST: pir:S75786; phosphoribosylformylglycinamidine cyclo-ligase (EC; E=3e-82 ddbj:BAB04350.1; (AP001509) phosphoribosylaminoimidazole; E=7e-82 swissprot:P12043; PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE; E=8e-77 COG: slr0838; COG0150 Phosphoribosylaminoimidazol (AIR) synthetase; E=3e-83 PFAM: PF00586; AIR synthase related protein, N-term; E=2.2e-55 PF02769; AIR synthase related protein, C-term; E=9.4e-36. | 0.677 |
| glyA | folD | RB6215 | RB7468 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.989 |
| glyA | pur3 | RB6215 | RB7260 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase; PMID: 95004650 best DB hits: BLAST: embl:CAA52779.2; (X74767) phosphoribosylglycinamide; E=1e-25 swissprot:P52422; PUR3_ARATH PHOSPHORIBOSYLGLYCINAMIDE; E=1e-25 pir:T11574; phosphoribosylglycinamide formyltransferase (EC 2.1.2.2); E=2e-25 COG: aq_857; COG0299 Folate-dependent phosphoribosylglycinamide; E=1e-23 VC1992; COG0788 Formyltetrahydrofolate hydrolase; E=9e-12 Cj0187c; COG0299 Folate-dependent phosphoribosylglycinamide; E=4e-11 PFAM: PF00551; Formyl transferase; E=2.9e-41. | 0.971 |
| glyA | purA | RB6215 | RB12924 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.884 |
| glyA | purB | RB6215 | RB8343 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.892 |
| glyA | purD | RB6215 | RB6616 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylamine-glycine ligase; PMID: 8299947 best DB hits: BLAST: pir:T46882; phosphoribosylamine--glycine ligase (EC 6.3.4.13); E=1e-108 pir:I67805; purine synthesis multifunctional protein - mouse -----; E=1e-108 gb:AAC53250.1; (U20892) glycinamide ribonucleotide synthetase; E=1e-107 COG: BH0634; COG0151 Phosphoribosylamine-glycine ligase; E=1e-108 PFAM: PF02844; Phosphoribosylglycinamide syn; E=6.3e-55 PF02842; Phosphoribosylglycinamide syn; E=2.5e-30 PF01837; Domain of unknown function DU; E=0.23. | 0.874 |
| glyA | purF | RB6215 | RB5050 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase [precursor]; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.871 |
| glyA | purH | RB6215 | RB10113 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113. | 0.996 |
| glyA | purL | RB6215 | RB5395 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.914 |
| glyA | purM | RB6215 | RB12745 | Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine cyclo-ligase; PMID: 3015935 PMID: 3530323 best DB hits: BLAST: pir:S75786; phosphoribosylformylglycinamidine cyclo-ligase (EC; E=3e-82 ddbj:BAB04350.1; (AP001509) phosphoribosylaminoimidazole; E=7e-82 swissprot:P12043; PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE; E=8e-77 COG: slr0838; COG0150 Phosphoribosylaminoimidazol (AIR) synthetase; E=3e-83 PFAM: PF00586; AIR synthase related protein, N-term; E=2.2e-55 PF02769; AIR synthase related protein, C-term; E=9.4e-36. | 0.772 |
| pur3 | folD | RB7260 | RB7468 | Phosphoribosylglycinamide formyltransferase; PMID: 95004650 best DB hits: BLAST: embl:CAA52779.2; (X74767) phosphoribosylglycinamide; E=1e-25 swissprot:P52422; PUR3_ARATH PHOSPHORIBOSYLGLYCINAMIDE; E=1e-25 pir:T11574; phosphoribosylglycinamide formyltransferase (EC 2.1.2.2); E=2e-25 COG: aq_857; COG0299 Folate-dependent phosphoribosylglycinamide; E=1e-23 VC1992; COG0788 Formyltetrahydrofolate hydrolase; E=9e-12 Cj0187c; COG0299 Folate-dependent phosphoribosylglycinamide; E=4e-11 PFAM: PF00551; Formyl transferase; E=2.9e-41. | 5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
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