Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
RB10172Aldehyde dehydrogenase; PMID: 9369242 best DB hits: BLAST: gb:AAA64636.1; (U07235) aldehyde dehydrogenase [Mus musculus]; E=1e-163 gb:AAA51693.1; (M20456) aldehyde dehydrogenase [Homo sapiens]; E=1e-163 pir:DEHUE2; aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) 2 precursor,; E=1e-162 COG: BH0539; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-156 PFAM: PF00171; Aldehyde dehydrogenase family; E=1.5e-240; Belongs to the aldehyde dehydrogenase family. (489 aa)    
Predicted Functional Partners:
yjgB
Hypothetical zinc-type alcohol dehydrogenase-like protein yjgB; PMID: 87304248 PMID: 92277668 best DB hits: BLAST: pir:S76928; probable aryl alcohol dehydrogenase (EC 1.1.1.-) -; E=1e-94 pir:S56495; probable aryl alcohol dehydrogenase (EC 1.1.1.-) yjgB -; E=6e-71 swissprot:P27250; YJGB_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL; E=6e-71 COG: slr1192; COG1064 Zn-dependent alcohol dehydrogenases; E=9e-96 PFAM: PF00899; ThiF family; E=0.48 PF02826; D-isomer specific 2-hydroxyacid; E=0.48 PF00107; Zinc-binding dehydrogenases; E=5.9e-85.
  
 0.913
RB683
Aldehyde dehydrogenase; PMID: 7484410 best DB hits: BLAST: gb:AAF52769.1; (AE003624) CG3752 gene product [Drosophila; E=5e-73 ddbj:BAA34785.1; (AB015226) RALDH2 [Homo sapiens]; E=2e-72 swissprot:O94788; DHAS_HUMAN RETINALDEHYDE-SPECIFIC DEHYDROGENASE; E=2e-72 COG: YOR374w; COG1012 NAD-dependent aldehyde dehydrogenases; E=2e-71 PFAM: PF00171; Aldehyde dehydrogenase family; E=7e-156.
  
  
 
0.911
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.909
RB3816
3-hydroxyisobutyrate dehydrogenase; PMID: 2647728 best DB hits: BLAST: pir:T08967; hypothetical protein F19B15.150 - Arabidopsis thaliana; E=3e-78 swissprot:O34948; YKWC_BACSU HYPOTHETICAL 30.7 KD PROTEIN IN; E=8e-71 gb:AAK06313.1; AE006450_6 (AE006450) 3-hydroxyisobutyrate; E=6e-70 COG: BS_ykwC; COG2084 3-hydroxyisobutyrate dehydrogenase and related; E=7e-72.
  
 
 0.909
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.902
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
     
 0.902
ackA-2
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.902
RB8840
Probable acylphosphatase; PMID: 9395090 best DB hits: BLAST: pir:G72240; hypothetical protein TM1564 - Thermotoga maritima; E=3e-04 embl:CAA58988.1; (X84195) acylphosphatase [Homo sapiens]; E=9e-04 swissprot:P00818; ACYM_HORSE ACYLPHOSPHATASE, MUSCLE TYPE; E=0.001 COG: TM1564; COG1254 Acylphosphatases; E=3e-05 PFAM: PF00708; Acylphosphatase; E=0.02.
     
 0.901
RB10787
Conserved hypothetical protein-putative glycerate kinase; Best DB hits: BLAST: pir:A72236; hypothetical protein TM1585 - Thermotoga maritima; E=8e-33 pir:B71162; hypothetical protein PH0495 - Pyrococcus horikoshii; E=6e-30 swissprot:Q44472; TUD4_AGRVI PUTATIVE HYDROXYPYRUVATE REDUCTASE; E=5e-29 COG: TM1585; COG2379 Putative glycerate kinase; E=8e-34.
     
  0.900
RB12303
Best DB hits: BLAST: pir:H69064; serinethreonine protein kinase related protein -; E=3e-04 gb:AAG20856.1; (AE005154) Vng6189h [Halobacterium sp. NRC-1]; E=0.007 gb:AAF16758.1; AC010155_11 (AC010155) F3M18.23 [Arabidopsis; E=0.014 COG: MTH1485; COG1520 Uncharacterized proteins of WD40-like repeat family; E=3e-05 PFAM: PF01011; PQQ enzyme repeat; E=0.0074.
     
  0.900
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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