STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrCDihydroorotase; PMID: 7516791 best DB hits: BLAST: pir:D82736; dihydroorotase XF0988 [imported] - Xylella fastidiosa; E=1e-86 pir:B82954; probable dihydroorotase PA5541 [imported] - Pseudomonas; E=2e-72 swissprot:O27199; PYRC_METTH DIHYDROOROTASE (DHOASE) -----; E=7e-51 COG: XF0988; COG0044 Dihydroorotase; E=9e-88 PFAM: PF02612; N-acetylglucosamine-6-phosphat; E=3.6e-06 PF00744; Dihydroorotase-like; E=2.4e-72. (470 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase, catalytic subunit (pyrB); PMID: 6364131 PMID: 6302686 PMID: 6341995 PMID: 10318893 PMID: 2271529 best DB hits: BLAST: gb:AAB91125.1; (AE001099) aspartate carbamoyltransferase,; E=3e-31 swissprot:P96174; PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE; E=7e-30 embl:CAC11715.1; (AL445064) probable aspartate; E=2e-29 COG: AF0106; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=2e-32 AF1255; COG0078 Ornithine carbamoyltransferase; E=2e-10 PFAM: PF02729; Aspartate/ornithine carbamoyltransfe; E=3.6e-20 PF00185; Aspartate/ornithine carbamoyltransfe; E=3e-0 [...]
 0.999
pyrB-2
Aspartate carbamoyltransferase; PMID: 97000351 best DB hits: BLAST: embl:CAB93367.1; (AL357523) aspartate carbamoyltransferase; E=4e-67 swissprot:P74163; PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE; E=6e-64 swissprot:Q59711; PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE; E=5e-63 COG: slr1476; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=6e-65 PFAM: PF02729; Aspartate/ornithine carbamoylt; E=1.1e-44 PF01229; Glycosyl hydrolases family 39; E=0.23 PF00185; Aspartate/ornithine carbamoylt; E=7.1e-18; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
carB
PMID: 8905231 PMID: 6308632 best DB hits: BLAST: swissprot:P00968; CARB_ECOLI CARBAMOYL-PHOSPHATE SYNTHASE LARGE; E=0.0 pir:S76557; carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC; E=0.0 gb:AAG10606.1; AC008030_6 (AC008030) carbamoyl phosphate synthetase; E=0.0 COG: AF1274; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 carB; COG0458 Carbamoylphosphate synthase large subunit (split gene in; E=0.0 BU144; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 PFAM: PF00289; Carbamoyl-phosphate synthase L; E=2.9e-53 PF02222; ATP-grasp domain; E [...]
 
 0.989
carA
Carbamoyl-phosphate synthase, small chain; PMID: 2843375 PMID: 6330744 best DB hits: BLAST: pir:E82083; carbamoyl-phosphate synthase, small chain VC2390; E=1e-99 pir:C70337; carbamoyl phosphate synthetase small subunit - Aquifex; E=3e-98 pir:S76783; hypothetical protein - Synechocystis sp. (strain PCC; E=6e-96 COG: VC2390; COG0505 Carbamoylphosphate synthase small subunit; E=1e-100 PFAM: PF00988; Carbamoyl-phosphate synthase; E=8.7e-82 PF00117; Glutamine amidotransferase cl; E=5.7e-62; Belongs to the CarA family.
  
 0.989
pyrK
PMID: 7516791 best DB hits: BLAST: swissprot:P46536; PYRK_BACCL DIHYDROOROTATE DEHYDROGENASE ELECTRON; E=1e-21 swissprot:Q58841; PYRK_METJA PROBABLE DIHYDROOROTATE DEHYDROGENASE; E=1e-17 swissprot:O27280; PYRK_METTH PROBABLE DIHYDROOROTATE DEHYDROGENASE; E=1e-16 COG: MJ1446; COG0543 2-polyprenylphenol hydroxylase and related; E=1e-18 PFAM: PF00970; Oxidoreductase FAD-binding doma; E=0.3.
 
 
 0.984
pyrD-2
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.969
RB9748
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 0.965
RB4738
Best DB hits: BLAST: pir:S77079; hypothetical protein sll0744 - Synechocystis sp. (strain; E=5e-32 gb:AAA57474.1; (U09178) dihydropyrimidine dehydrogenase [Homo; E=1e-09 ddbj:BAA89789.1; (AB003063) dihydropyrimidine dehydrogenase [Homo; E=1e-09 COG: sll0744; COG0167 Dihydroorotate dehydrogenase; E=5e-33 PFAM: PF00977; Histidine biosynthesis protein; E=0.064.
  
 0.960
pyrD
Dihydroorotate dehydrogenase; Best DB hits: BLAST: pir:S77079; hypothetical protein sll0744 - Synechocystis sp. (strain; E=6e-36 swissprot:Q9YFI6; PYRD_AERPE DIHYDROOROTATE DEHYDROGENASE; E=6e-13 swissprot:Q58070; PYRD_METJA DIHYDROOROTATE DEHYDROGENASE; E=2e-10 COG: sll0744; COG0167 Dihydroorotate dehydrogenase; E=5e-37 PFAM: PF01729; Quinolinate phosphoribosyl tra; E=0.47 PF00977; Histidine biosynthesis protein; E=0.34 PF01884; PcrB family; E=0.35.
  
 0.960
pyrC-2
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
  
  
 
0.928
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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