Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
pynPyrimidine-nucleoside phosphorylase (PYNP); PMID: 8987664 PMID: 9817849 PMID: 8987664 best DB hits: BLAST: pdb:1BRW; B Chain B, The Crystal Structure Of Pyrimidine; E=3e-70 swissprot:P77836; PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE; E=3e-69 swissprot:O53366; DEOA_MYCTU THYMIDINE PHOSPHORYLASE (TDRPASE); E=1e-68 COG: Rv3314c; COG0213 Thymidine phosphorylase; E=1e-69 PFAM: PF02885; Glycosyl transferase family,; E=1.4e-15 PF00591; Glycosyl transferase family,; E=6.1e-39. (423 aa)    
Predicted Functional Partners:
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
 0.998
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
 
 
 0.962
tdk
Thymidine kinase Tdk; PMID: 2060797 PMID: 2041474 best DB hits: BLAST: gb:AAK03320.1; (AE006163) Tdk [Pasteurella multocida]; E=2e-66 swissprot:P44309; KITH_HAEIN THYMIDINE KINASE -----pir:; E=3e-65 swissprot:P23331; KITH_ECOLI THYMIDINE KINASE ----- pir:; E=2e-64 COG: HI0529; COG1435 Thymidine kinase; E=3e-66 PFAM: PF00265; Thymidine kinase; E=4.9e-88.
 
  
 0.941
upp
Uracil phosphoribosyltransferase; PMID: 7798145 best DB hits: BLAST: ddbj:BAB07483.1; (AP001519) uracil phosphoribosyltransferase; E=8e-45 pir:T48896; uracil phosphoribosyltransferase (EC 2.4.2.9) upp; E=3e-43 swissprot:P39149; UPP_BACSU URACIL PHOSPHORIBOSYLTRANSFERASE (UMP; E=8e-42 COG: BH3764; COG0035 Uracil phosphoribosyltransferase; E=7e-46 PFAM: PF00156; Phosphoribosyl transferase doma; E=6.1e-05; Belongs to the UPRTase family.
    
 0.937
surE
Acid phosphatase SurE; PMID: 8905231 best DB hits: BLAST: swissprot:P73440; YE59_SYNY3 HYPOTHETICAL 24.9 KD PROTEIN SLL1459; E=4e-31 swissprot:O83434; SURE_TREPA STATIONARY-PHASE SURVIVAL PROTEIN; E=3e-22 gb:AAD51394.1; AF117715_3 (AF117715) survival protein homolog; E=4e-20 COG: sll1459; COG0496 Survival protein, predicted acid phosphatase; E=4e-32 PFAM: PF01975; Survival protein SurE; E=9.8e-49.
    
 0.911
ppnP
Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
 0.911
surE-2
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.911
RB8824
Cytosine deaminase; PMID: 9000374 best DB hits: BLAST: swissprot:P78594; FCA1_CANAL CYTOSINE DEAMINASE (CYTOSINE; E=9e-32 gb:AAC13409.1; (U55193) cytosine deaminase [Saccharomyces; E=8e-30 gb:AAG33626.1; AF312392_1 (AF312392) cytosine deaminase-uracil; E=8e-30 COG: YPR062w; COG0590 Cytosine/adenosine deaminases; E=8e-31 PFAM: PF00383; Cytidine and deoxycytidylate de; E=6.1e-24.
     
  0.900
nagD
N-acetylglucosamine-6-phoshatase or p-nitrophenyl phosphatase; PMID: 97000351 PMID: 99411980 PMID: 2668691 PMID: 2190615 best DB hits: BLAST: embl:CAB65573.1; (AL136058) probable; E=1e-51 ddbj:BAB07147.1; (AP001518) p-nitrophenyl phosphatase [Bacillus; E=4e-43 swissprot:P15302; NAGD_ECOLI NAGD PROTEIN ----- pir: B64802; E=6e-42 COG: BH3428; COG0647 Predicted sugar phosphatases of the HAD superfamily; E=4e-44 VNG0719G; COG0647 Predicted sugar phosphatases of the HAD; E=7e-31 BH1074; COG0647 Predicted sugar phosphatases of the HAD superfamily; E=2e-24 PFAM: PF00702; haloacid dehalogenase [...]
     
  0.900
RB8680
Cleavage and polyadenylation specifity factor-related protein; Best DB hits: BLAST: ddbj:BAA33615.1; (AB012956) unknown [Vibrio cholerae]; E=6e-99 pir:F82345; conserved hypothetical protein VC0264 [imported] -; E=9e-96 gb:AAD54657.1; AF090685_1 (AF090685) hypothetical protein [Vibrio; E=7e-67 COG: VC0264; COG1236 Predicted exonuclease of the beta-lactamase fold; E=9e-97 MJ1236; COG1782 Predicted metal-dependent RNase, consists of a; E=4e-39 MJ0162; COG1236 Predicted exonuclease of the beta-lactamase fold; E=1e-26 PFAM: PF00753; Metallo-beta-lactamase superfami; E=9.3e-07.
 
    0.681
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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