STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pynPyrimidine-nucleoside phosphorylase (PYNP); PMID: 8987664 PMID: 9817849 PMID: 8987664 best DB hits: BLAST: pdb:1BRW; B Chain B, The Crystal Structure Of Pyrimidine; E=3e-70 swissprot:P77836; PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE; E=3e-69 swissprot:O53366; DEOA_MYCTU THYMIDINE PHOSPHORYLASE (TDRPASE); E=1e-68 COG: Rv3314c; COG0213 Thymidine phosphorylase; E=1e-69 PFAM: PF02885; Glycosyl transferase family,; E=1.4e-15 PF00591; Glycosyl transferase family,; E=6.1e-39. (423 aa)    
Predicted Functional Partners:
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
 0.998
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
 
 
 0.954
upp
Uracil phosphoribosyltransferase; PMID: 7798145 best DB hits: BLAST: ddbj:BAB07483.1; (AP001519) uracil phosphoribosyltransferase; E=8e-45 pir:T48896; uracil phosphoribosyltransferase (EC 2.4.2.9) upp; E=3e-43 swissprot:P39149; UPP_BACSU URACIL PHOSPHORIBOSYLTRANSFERASE (UMP; E=8e-42 COG: BH3764; COG0035 Uracil phosphoribosyltransferase; E=7e-46 PFAM: PF00156; Phosphoribosyl transferase doma; E=6.1e-05; Belongs to the UPRTase family.
  
 
 0.953
tdk
Thymidine kinase Tdk; PMID: 2060797 PMID: 2041474 best DB hits: BLAST: gb:AAK03320.1; (AE006163) Tdk [Pasteurella multocida]; E=2e-66 swissprot:P44309; KITH_HAEIN THYMIDINE KINASE -----pir:; E=3e-65 swissprot:P23331; KITH_ECOLI THYMIDINE KINASE ----- pir:; E=2e-64 COG: HI0529; COG1435 Thymidine kinase; E=3e-66 PFAM: PF00265; Thymidine kinase; E=4.9e-88.
 
  
 0.941
pnp
Purine nucleoside phosphorylase I; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
 
  
 0.930
punA
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.919
surE
Acid phosphatase SurE; PMID: 8905231 best DB hits: BLAST: swissprot:P73440; YE59_SYNY3 HYPOTHETICAL 24.9 KD PROTEIN SLL1459; E=4e-31 swissprot:O83434; SURE_TREPA STATIONARY-PHASE SURVIVAL PROTEIN; E=3e-22 gb:AAD51394.1; AF117715_3 (AF117715) survival protein homolog; E=4e-20 COG: sll1459; COG0496 Survival protein, predicted acid phosphatase; E=4e-32 PFAM: PF01975; Survival protein SurE; E=9.8e-49.
    
 0.914
surE-2
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.914
ppnP
Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
 0.912
RB1934
Alkaline phosphatase; PMID: 1712356 best DB hits: BLAST: pir:A47026; alkaline phosphatase, 145K - Synechococcus sp. (strain PCC; E=0.0 pir:S74916; alkaline phosphatase - Synechocystis sp. (strain PCC 6803); E=1e-108 pir:A69809; probable multifunctional phosphoesterase (EC 3.1.-.-) yfkN; E=5e-22 COG: sll0654_2; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase; E=8e-99 DRA0018; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and; E=1e-22 BS_yfkN_2; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase; E=4e-22 PFAM: PF01009; 5'-nucleotidase, catalytic do; E=1e-32 PF02872; 5 [...]
    
 0.909
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.