Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
htrASimilar to serine proteinase HtrA; PMID: 9371463 best DB hits: BLAST: pir:D69109; serine proteinase HtrA - Methanobacterium; E=0.014 embl:CAA72164.1; (Y11304) ORF E0 [Rhodobacter capsulatus]; E=0.018 gb:AAF87931.1; AF163841_10 (AF163841) putative serine protease; E=0.041 COG: MTH1813; COG0265 Trypsin-like serine proteases, typically; E=0.001 PFAM: PF00595; PDZ domain (Also known as DHR; E=0.0018. (493 aa)    
Predicted Functional Partners:
rpoA-2
PMID: 9835038 best DB hits: BLAST: swissprot:O50634; RPOA_BACHD DNA-DIRECTED RNA POLYMERASE ALPHA; E=2e-09 swissprot:Q9Z3E7; RPOA_XANCP DNA-DIRECTED RNA POLYMERASE ALPHA; E=4e-09 gb:AAD00325.2; (U79735) RNA polymerase ALPHA subunit [Xanthomonas; E=4e-09 COG: BH0162; COG0202 DNA-directed RNA polymerase alpha subunit/40 kD; E=2e-10 PFAM: PF00515; TPR Domain; E=0.87 PF01000; Bacterial RNA polymerase, alpha; E=6.5e-12.
  
 
 0.657
pgi
Glucose-6-phosphate isomerase; PMID: 2549364 best DB hits: BLAST: swissprot:P80860; G6PI_BACSU GLUCOSE-6-PHOSPHATE ISOMERASE (GPI); E=6e-53 ddbj:BAB07062.1; (AP001518) glucose-6-phosphate isomerase; E=4e-52 pir:S15937; glucose-6-phosphate isomerase (EC 5.3.1.9) - Bacillus; E=5e-52 COG: BS_pgi; COG0166 Glucose-6-phosphate isomerase; E=6e-54 PFAM: PF00342; Phosphoglucose isomerase; E=6.8e-31.
   
 
 0.648
argS
arginyl-tRNA synthetase; PMID: 2668891 best DB hits: BLAST: pir:G82121; arginyl-tRNA synthetase VC2074 [imported] - Vibrio; E=1e-69 swissprot:Q55486; SYR_SYNY3 ARGINYL-TRNA SYNTHETASE; E=5e-68 embl:CAC01600.1; (AJ269505) putative arginyl-tRNA synthetase; E=4e-66 COG: VC2074; COG0018 Arginyl-tRNA synthetase; E=1e-70 PFAM: PF00750; tRNA synthetases class I (R); E=5.7e-55.
  
  
 0.630
fusA
Elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
   
 
 0.628
fusA-2
Elongation factor G; PMID: 8070396 PMID: 11054294 best DB hits: BLAST: embl:CAB81852.1; (AL161691) elongation factor G [Streptomyces; E=1e-147 swissprot:O66428; EFG_AQUAE ELONGATION FACTOR G (EF-G) -----; E=1e-145 swissprot:P38525; EFG_THEMA ELONGATION FACTOR G (EF-G) -----; E=1e-145 COG: aq_001; COG0480 Translation elongation and release factors (GTPases); E=1e-146 jhp1118; COG0480 Translation elongation and release factors; E=1e-139 BH0131; COG0480 Translation elongation and release factors (GTPases); E=1e-138 PFAM: PF01894; Uncharacterised protein family UPF; E=0.082 PF00009; Elonga [...]
   
 
 0.628
infB
Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
   
  
 0.626
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
   
  
 0.622
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.622
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.622
rpoA-3
PMID: 3093467 best DB hits: BLAST: swissprot:P20429; RPOA_BACSU DNA-DIRECTED RNA POLYMERASE ALPHA; E=1e-07 gb:AAA81287.1; (U30821) alpha subunit of RNA polymerase; E=5e-07 swissprot:O50634; RPOA_BACHD DNA-DIRECTED RNA POLYMERASE ALPHA; E=1e-06 COG: BS_rpoA; COG0202 DNA-directed RNA polymerase alpha subunit/40 kD; E=1e-08 PFAM: PF01000; Bacterial RNA polymerase, alpha; E=8.2e-15.
   
  
 0.622
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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