Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
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gly1Low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (349 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.938
thrC
Threonine synthase precursor; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
    
 0.933
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
 0.931
yqhK
Probable glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
    
 0.921
yqhJ
Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
    
 0.921
RB10305
Hypothetical protein; PMID: 11474104.
       0.639
RB10308
Probable response regulatory protein; PMID: 9823893 PMID: 10984043 best DB hits: BLAST: pir:A71678; probable response regulatory protein RP237 - Rickettsia; E=2e-21 pir:A82428; sensory boxGGDEF family protein VCA0697 [imported] -; E=6e-21 pir:E83183; probable two-component response regulator PA3702; E=1e-20 COG: VCA0697_3; COG2199 Diguanylate cyclase/phosphodiesterase domain 1; E=6e-22 PFAM: PF00072; Response regulator receiver doma; E=5.4e-17 PF00990; GGDEF domain; E=7.2e-44.
       0.551
eutE
Ethanolamine utilization protein EutE; PMID: 11677609 best DB hits: BLAST: swissprot:P41793; EUTE_SALTY ETHANOLAMINE UTILIZATION PROTEIN EUTE; E=5e-84 gb:AAG57564.1; AE005474_12 (AE005474) ethanolamine utilization; E=1e-83 swissprot:P77445; EUTE_ECOLI ETHANOLAMINE UTILIZATION PROTEIN EUTE; E=5e-83 COG: eutE; COG1012 NAD-dependent aldehyde dehydrogenases; E=5e-84 PFAM: PF00171; Aldehyde dehydrogenase family; E=0.21.
     
 0.511
RB6500
Mycocerosate synthase; PMID: 3880746 best DB hits: BLAST: pir:S72705; mycocerosate synthase (EC 2.3.1.111) - Mycobacterium; E=0.0 pir:H70819; probable polyketide synthase - Mycobacterium tuberculosis; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=1e-180 COG: PA2402_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=4e-99 BS_ppsD_3; COG1020 Non-ribosomal peptide synthetase modules and; E=4e-92 PA2424_2; COG1020 Non-ribosomal peptide synthetase modules and related; E=1e-91 PFAM: PF00108; Thiolase, N-terminal domain; E=2.7e-06 PF00109; Beta-keto [...]
     
 0.465
RB10300
Hypothetical protein-signal peptide and transmembrane prediction; Best DB hits: BLAST: gb:AAG19252.1; (AE005021) plastocyanin homology; Pcy; E=0.67.
       0.454
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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