Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RB10322Two-component sensor histidine kinase; PMID: 10086841 PMID: 10086842 PMID: 10192928 best DB hits: BLAST: ddbj:BAB05639.1; (AP001513) two-component sensor histidine kinase; E=5e-22 swissprot:Q06067; ATOS_ECOLI SENSOR PROTEIN ATOS ----- pir:; E=1e-21 pir:S70528; sensor protein pilS - Myxococcus xanthus -----gb:; E=2e-21 COG: BH1920; COG0642 Sensory transduction histidine kinases; E=5e-23 PFAM: PF00785; PAC motif; E=0.099 PF00512; His Kinase A (phosphoacceptor) doma; E=7.9e-10 PF02518; Histidine kinase-, DNA gyrase B-, p; E=1.1e-33. (459 aa)    
Predicted Functional Partners:
atoC
Acetoacetate metabolism regulatory protein atoC; PMID: 9278503 PMID: 9097040 PMID: 8346225 best DB hits: BLAST: swissprot:Q06065; ATOC_ECOLI ACETOACETATE METABOLISM REGULATORY; E=6e-93 pir:F71315; probable response regulatory protein (atoC) - syphilis; E=7e-93 gb:AAF33506.1; (AF170176) Salmonella typhimurium transcriptional; E=3e-89 COG: atoC; COG2204 AAA superfamily ATPases with N-terminal receiver; E=5e-94 PFAM: PF00072; Response regulator receiver doma; E=1.5e-34 PF00158; Sigma-54 interaction domain; E=1.2e-133.
 
   0.900
RB5478
Putative two-component system response regulator; PMID: 7699720 best DB hits: BLAST: embl:CAB88489.1; (AL353816) putative two-component systen; E=1e-15 gb:AAB06615.1; (U53173) MviA [Salmonella typhimurium]; E=2e-14 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=1e-13 COG: slr0115; COG0745 Response regulators consisting of a CheY-like; E=1e-13 XF1952_3; COG0784 CheY-like receiver domains; E=3e-13 Rv0981; COG0745 Response regulators consisting of a CheY-like; E=3e-12 PFAM: PF00072; Response regulator receiver doma; E=2.4e-27.
  
 
   0.777
RB10324
Hypothetical protein.
       0.773
RB10326
Best DB hits: BLAST: pir:D83631; probable sulfate transporter PA0103 [imported] -; E=6e-41 pir:B70979; hypothetical protein Rv3273 - Mycobacterium tuberculosis; E=2e-37 pir:T36683; probable integral membrane protein - Streptomyces; E=7e-31 COG: PA0103; COG0659 Sulfate permease and related transporters (MFS; E=6e-42 PFAM: PF00916; Sulfate transporter family; E=5.9e-11.
     
 0.773
RB5472
Probable two-component system response regulator; PMID: 1454550 best DB hits: BLAST: embl:CAB94653.1; (AL359215) putative two-component system; E=3e-12 pir:D72374; response regulator - Thermotoga maritima (strain MSB8); E=2e-11 embl:CAC04498.1; (AL391588) putative two-component system; E=5e-11 COG: TM0468; COG0784 CheY-like receiver domains; E=2e-12 BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=3e-11 slr0322_3; COG0784 CheY-like receiver domains; E=3e-10 PFAM: PF00072; Response regulator receiver doma; E=9.1e-23.
  
 
   0.761
RB6217
Putative response regulator; PMID: 10376842 best DB hits: BLAST: gb:AAD28578.1; AF121341_2 (AF121341) putative response regulator; E=7e-27 gb:AAA87378.1; (L42554) pleD gene product [Caulobacter; E=3e-21 pir:S74913; sensory transduction system regulatory protein slr1400 -; E=4e-21 COG: slr1400_1; COG0784 CheY-like receiver domains; E=4e-20 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-19 VC0622_4; COG0784 CheY-like receiver domains; E=4e-19 PFAM: PF00072; Response regulator receiver doma; E=3.1e-37.
  
 
   0.759
cheY-3
Two-component system response regulator; PMID: 1454550 best DB hits: BLAST: embl:CAB90891.1; (AL355753) two-component system response; E=4e-40 swissprot:P37478; YYCF_BACSU HYPOTHETICAL 27.2 KD SENSORY; E=5e-40 gb:AAD10263.1; (AF036966) putative response regulator; E=9e-40 COG: BS_yycF; COG0745 Response regulators consisting of a CheY-like; E=5e-41 ompR; COG0745 Response regulators consisting of a CheY-like receiver; E=8e-37 TM1655; COG0745 Response regulators consisting of a CheY-like; E=7e-36 PFAM: PF00072; Response regulator receiver doma; E=3.9e-38 PF00486; Transcriptional regulator [...]
  
 
   0.748
RB5943
Probable response regulator; PMID: 7699720 PMID: 1454550 best DB hits: BLAST: embl:CAA47908.1; (X67676) phoP [Bacillus subtilis]; E=1e-15 gb:AAA22661.1; (M16775) phoP protein (put.); putative [Bacillus; E=1e-15 swissprot:P13792; PHOP_BACSU ALKALINE PHOSPHATASE SYNTHESIS; E=1e-15 COG: BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=1e-16 sll0043_4; COG0784 CheY-like receiver domains; E=4e-15 Rv0757; COG0745 Response regulators consisting of a CheY-like; E=4e-15 PFAM: PF00072; Response regulator receiver doma; E=4.8e-28.
  
 
   0.745
RB11986
Histidine protein kinase homolog GacS; PMID: 10762268 best DB hits: BLAST: gb:AAF04854.1; AF197912_1 (AF197912) histidine protein kinase; E=3e-57 pir:E83212; probable sensorresponse regulator hybrid PA3462; E=4e-56 pir:H83132; probable sensorresponse regulator hybrid PA4112; E=8e-51 COG: PA3462; COG0642 Sensory transduction histidine kinases; E=3e-57 PFAM: PF00989; PAS domain; E=3.5e-07 PF00512; His Kinase A (phosphoacceptor; E=2.5e-21 PF02518; Histidine kinase-, DNA gyrase; E=6.8e-39.
 
 
 
 0.744
RB2621
Phosphate regulon response regulator PhoB; PMID: 10629178 PMID: 3537313 PMID: 9878437 best DB hits: BLAST: gb:AAF15533.1; AF196490_3 (AF196490) phosphate regulon response; E=2e-35 swissprot:Q52990; PHOB_RHIME PHOSPHATE REGULON TRANSCRIPTIONAL; E=2e-31 embl:CAA11074.1; (AJ223073) phosphate regulatory protein; E=9e-31 COG: PA5360; COG0745 Response regulators consisting of a CheY-like; E=5e-31 phoB; COG0745 Response regulators consisting of a CheY-like receiver; E=7e-31 TM1655; COG0745 Response regulators consisting of a CheY-like; E=1e-30 PFAM: PF00072; Response regulator receiver doma; [...]
  
 
   0.721
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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