STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lspAProbable prolipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (242 aa)    
Predicted Functional Partners:
RB10372
Similar to integral membrane protein; PMID: 10688204 best DB hits: BLAST: pir:B81282; probable integral membrane protein Cj1373 [imported] -; E=5e-09 COG: Cj1373; COG1033 Membrane proteins related to SecD/SecF; E=5e-10.
       0.778
RB10370
Conserved hypothetical protein-putative phosphatase; PMID: 8969498 best DB hits: BLAST: swissprot:P54607; YHCW_BACSU HYPOTHETICAL 24.7 KD PROTEIN IN; E=6e-15 ref:XP_010289.2; DNA segment, numerous copies, expressed probes; E=9e-14 gb:AAA58622.1; (M86934) Gene from Xp22.3 which escapes; E=4e-13 COG: BS_yhcW; COG0637 Predicted phosphatase/phosphohexomutase; E=6e-16 gph; COG0546 Predicted phosphatases; E=6e-08 PA2067; COG0637 Predicted phosphatase/phosphohexomutase; E=8e-08 PFAM: PF00702; haloacid dehalogenase-like hydrolas; E=2.1e-26.
       0.773
ileS
Probable isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
  
 0.644
lgt
Probable prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
 
   
 0.525
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
 
  
 0.503
yidC
60 kDa inner-membrane protein homolog-putative part of a protein secretion system; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).
  
   
 0.501
trxA
Thioredoxin; PMID: 2137818 PMID: 3280308 best DB hits: BLAST: swissprot:P08058; THIO_RHOSH THIOREDOXIN (TRX) ----- pir:; E=8e-17 swissprot:P43785; THIO_HAEIN THIOREDOXIN (TRX) ----- pir:; E=2e-14 swissprot:P00275; THI1_CORNE THIOREDOXIN C-1 ----- pir: TXFK; E=1e-13 COG: HI0084; COG0526 Thiol-disulfide isomerase and thioredoxins; E=2e-15 XF2174; COG3118 Thioredoxin domain-containing protein; E=2e-10 PA5240; COG0526 Thiol-disulfide isomerase and thioredoxins; E=2e-10 PFAM: PF00085; Thioredoxin; E=1.1e-24.
     
 0.499
lnt
Probable apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.
 
   
 0.493
secD
Protein-export membrane protein secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
     
 0.473
RB5205
Probable peptidyl-prolyl cis-trans isomerase; PMID: 2186809 best DB hits: BLAST: ddbj:BAB04896.1; (AP001511) protein secretion (post-translocation; E=2e-08 pir:E71662; protein export protein prsa precursor (prsA) RP576 -; E=3e-05 pir:A83421; peptidyl-prolyl cis-trans isomerase D PA1805 [imported]; E=4e-05 COG: BH1177; COG0760 Parvulin-like peptidyl-prolyl isomerase; E=2e-09 PFAM: PF00639; PPIC-type PPIASE domain; E=2.4e-08.
  
  
 0.456
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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