Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
Experiments
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[Homology]
Score
recQrecQ; PMID: 3027506 PMID: 3027506 best DB hits: BLAST: gb:AAA24517.1; (M30198) recQ [Escherichia coli]; E=2e-78 gb:AAA67618.1; (M87049) DNA-dependent ATPase, DNA helicase; E=2e-78 pir:BVECRQ; DNA helicase recQ - Escherichia coli (strain K-12); E=2e-78 COG: recQ; COG0514 Superfamily II DNA helicase; E=2e-79 PFAM: PF00270; DEAD/DEAH box helicase; E=2.7e-39 PF00271; Helicase conserved C-terminal doma; E=2.1e-28. (1002 aa)    
Predicted Functional Partners:
recQ-3
ATP-dependent DNA helicase RecQ; PMID: 3027506 best DB hits: BLAST: pir:E83226; ATP-dependent DNA helicase RecQ PA3344 [imported] -; E=1e-127 pir:T34609; probable helicase - Streptomyces coelicolor -----; E=1e-126 pir:G75413; DNA helicase RecQ - Deinococcus radiodurans (strain R1); E=1e-125 COG: PA3344; COG0514 Superfamily II DNA helicase; E=1e-128 slr0083; COG0513 Superfamily II DNA and RNA helicases; E=1e-12 PFAM: PF00271; Helicase conserved C-terminal dom; E=0.15 PF00270; DEAD/DEAH box helicase; E=2.2e-29 PF00271; Helicase conserved C-terminal dom; E=1.9e-25.
  
  
 
0.923
recQ-5
ATP-dependent DNA helicase RecQ; PMID: 3027506 PMID: 2164680 best DB hits: BLAST: gb:AAK05906.1; AE006411_1 (AE006411) ATP-dependent DNA helicase; E=9e-60 pir:E83226; ATP-dependent DNA helicase RecQ PA3344 [imported] -; E=4e-58 pir:G75413; DNA helicase RecQ - Deinococcus radiodurans (strain R1); E=1e-56 COG: PA3344; COG0514 Superfamily II DNA helicase; E=4e-59 YPL119c; COG0513 Superfamily II DNA and RNA helicases; E=5e-12 PFAM: PF00270; DEAD/DEAH box helicase; E=1e-32 PF00271; Helicase conserved C-terminal d; E=3.8e-26.
  
  
 
0.923
recQ-2
ATP-dependent DNA helicase RecQ; PMID: 3027506 PMID: 2164680 best DB hits: BLAST: pir:E82351; ATP-dependent DNA helicase RecQ VC0196 [imported] -; E=1e-68 swissprot:P50729; RECQ_BACSU ATP-DEPENDENT DNA HELICASE RECQ; E=4e-65 gb:AAA24517.1; (M30198) recQ [Escherichia coli]; E=7e-65 COG: VC0196; COG0514 Superfamily II DNA helicase; E=1e-69 YNL112w; COG0513 Superfamily II DNA and RNA helicases; E=3e-13 PFAM: PF00270; DEAD/DEAH box helicase; E=1.2e-39 PF00271; Helicase conserved C-terminal doma; E=2e-23.
  
  
 
0.919
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.868
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.739
recJ
Single-strand DNA-specific exonuclease; PMID: 1987126 PMID: 2649886 best DB hits: BLAST: ddbj:BAB04959.1; (AP001511) single-strand DNA-specific; E=5e-91 pir:H69980; single-strand DNA-specific exonuclease homolog yrvE -; E=3e-88 pir:D72062; single-stranded-DNA-specific exonuclease RecJ CP0187; E=3e-73 COG: BH1240_1; COG0608 Single-stranded DNA-specific exonuclease; E=5e-92 PFAM: PF01368; DHH family; E=3e-41 PF02272; DHHA1 domain; E=0.00061.
    
 0.702
RB6449
PMID: 7783620 best DB hits: BLAST: pir:A81937; IgA-specific metalloendopeptidase (EC 3.4.24.13) NMA0905; E=6e-08 pir:C81169; IgA-specific metalloendopeptidase (EC 3.4.24.13) NMB0700; E=9e-07 pir:T18296; myosin heavy chain - Entamoeba histolytica ----- gb:; E=9e-05.
   
 0.692
recA
RecA protein (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.629
RB8134
Conserved hypothetical protein-putative a helicase; PMID: 93188700 best DB hits: BLAST: embl:CAA19102.1; (AL023591) hypothetical protein MLCB1259.27; E=1e-95 swissprot:Q50739; YP59_MYCTU HYPOTHETICAL 47.5 KDA PROTEIN RV2559C; E=2e-91 embl:CAB93386.1; (AL357523) conserved ATPGTP binding protein; E=2e-90 COG: Rv2559c; COG2256 Uncharacterized ATPase related to the helicase; E=2e-92 ycaJ; COG2256 Uncharacterized ATPase related to the helicase subunit; E=4e-86 HI1590; COG2256 Uncharacterized ATPase related to the helicase; E=1e-85 PFAM: PF01057; Parvovirus non-structural pro; E=0.099 PF0091 [...]
    
 
 0.562
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.561
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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