STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cheYBest DB hits: BLAST: pir:G82805; two-component system, regulatory protein XF0450; E=5e-09 swissprot:P43501; PILH_PSEAE PILH PROTEIN ----- pir: S40035; E=3e-08 pir:F82618; chemotaxis-related protein kinase XF1952 [imported] -; E=6e-08 COG: XF0450; COG0784 CheY-like receiver domains; E=5e-10 PA2798; COG2204 AAA superfamily ATPases with N-terminal receiver; E=6e-08 BH1910_1; COG0784 CheY-like receiver domains; E=2e-07 PFAM: PF00072; Response regulator receiver doma; E=5.7e-25. (329 aa)    
Predicted Functional Partners:
RB10488
PMID: 20572072 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=3e-67 pir:E83443; probable sensorresponse regulator hybrid PA1611; E=2e-64 pir:H82211; sensory box sensor histidine kinaseresponse regulator; E=8e-61 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=7e-62 PFAM: PF00785; PAC motif; E=0.00076 PF00512; His Kinase A (phosphoacceptor) d; E=1.6e-28 PF02518; Histidine kinase-, DNA gyrase B-; E=1.6e-42.
 
 
 0.906
RB12326
Sensory histidine protein kinase; PMID: 11406410 best DB hits: BLAST: gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=2e-45 pir:F83153; probable two-component sensor PA3946 [imported] -; E=3e-36 pir:E83265; probable two-component sensor PA3044 [imported] -; E=2e-35 COG: PA3044; COG0642 Sensory transduction histidine kinases; E=2e-36 PFAM: PF01590; GAF domain; E=3.2e-20 PF00989; PAS domain; E=1.2e-07 PF00512; His Kinase A (phosphoacceptor) d; E=4.8e-16.
 
 
 0.820
hydH
Sensor kinase of the HydH/G two-component system; PMID: 2666400 PMID: 11243806 best DB hits: BLAST: gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=2e-23 gb:AAG09417.1; AF180147_9 (AF180147) bZIP histidine kinase TobS; E=5e-23 embl:CAB43735.1; (Y18245) bZIP histidine kinase [Pseudomonas; E=6e-23 COG: BH1920; COG0642 Sensory transduction histidine kinases; E=2e-22 PFAM: PF00072; Response regulator receiver doma; E=1.2e-21 PF00989; PAS domain; E=1e-08 PF00785; PAC motif; E=0.053.
 
 
 
 0.776
RB5943
Probable response regulator; PMID: 7699720 PMID: 1454550 best DB hits: BLAST: embl:CAA47908.1; (X67676) phoP [Bacillus subtilis]; E=1e-15 gb:AAA22661.1; (M16775) phoP protein (put.); putative [Bacillus; E=1e-15 swissprot:P13792; PHOP_BACSU ALKALINE PHOSPHATASE SYNTHESIS; E=1e-15 COG: BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=1e-16 sll0043_4; COG0784 CheY-like receiver domains; E=4e-15 Rv0757; COG0745 Response regulators consisting of a CheY-like; E=4e-15 PFAM: PF00072; Response regulator receiver doma; E=4.8e-28.
  
     0.772
RB2728
PMID: 8552028 best DB hits: BLAST: pir:D82244; sensory box sensor histidine kinase VC1084 [imported] -; E=4e-15 ddbj:BAB05639.1; (AP001513) two-component sensor histidine kinase; E=1e-13 pir:S60595; FixL protein - Rhizobium leguminosarum ----- gb:; E=3e-13 COG: VC1084; COG0642 Sensory transduction histidine kinases; E=3e-16 PFAM: PF00672; HAMP domain; E=2.9e-10 PF00512; His Kinase A (phosphoacceptor) doma; E=3.2e-08 PF02518; Histidine kinase-, DNA gyrase B-, p; E=7.9e-33.
 
 
 
 0.770
phoB
Probable regulatory components of sensory transduction system; PMID: 8905231 best DB hits: BLAST: embl:CAA11074.1; (AJ223073) phosphate regulatory protein; E=3e-11 pir:B70152; response regulatory protein (rrp-1) homolog - Lyme; E=1e-10 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=2e-10 COG: BB0419_1; COG0784 CheY-like receiver domains; E=1e-11 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-10 slr1305_1; COG0784 CheY-like receiver domains; E=3e-09 PFAM: PF00072; Response regulator receiver doma; E=1.4e-18.
  
     0.766
atoS-2
Sensor protein atoS; PMID: 8346225 best DB hits: BLAST: swissprot:Q06067; ATOS_ECOLI SENSOR PROTEIN ATOS ----- pir:; E=1e-26 gb:AAF33505.1; (AF170176) Salmonella typhimurium sensor protein; E=3e-25 gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=1e-24 COG: atoS_3; COG0642 Sensory transduction histidine kinases; E=1e-27 PFAM: PF00072; Response regulator receiver doma; E=2.2e-12 PF00989; PAS domain; E=1.6e-06 PF00785; PAC motif; E=0.00084.
 
 
 
 0.766
RB6217
Putative response regulator; PMID: 10376842 best DB hits: BLAST: gb:AAD28578.1; AF121341_2 (AF121341) putative response regulator; E=7e-27 gb:AAA87378.1; (L42554) pleD gene product [Caulobacter; E=3e-21 pir:S74913; sensory transduction system regulatory protein slr1400 -; E=4e-21 COG: slr1400_1; COG0784 CheY-like receiver domains; E=4e-20 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-19 VC0622_4; COG0784 CheY-like receiver domains; E=4e-19 PFAM: PF00072; Response regulator receiver doma; E=3.1e-37.
  
     0.765
RB5478
Putative two-component system response regulator; PMID: 7699720 best DB hits: BLAST: embl:CAB88489.1; (AL353816) putative two-component systen; E=1e-15 gb:AAB06615.1; (U53173) MviA [Salmonella typhimurium]; E=2e-14 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=1e-13 COG: slr0115; COG0745 Response regulators consisting of a CheY-like; E=1e-13 XF1952_3; COG0784 CheY-like receiver domains; E=3e-13 Rv0981; COG0745 Response regulators consisting of a CheY-like; E=3e-12 PFAM: PF00072; Response regulator receiver doma; E=2.4e-27.
  
     0.763
RB5472
Probable two-component system response regulator; PMID: 1454550 best DB hits: BLAST: embl:CAB94653.1; (AL359215) putative two-component system; E=3e-12 pir:D72374; response regulator - Thermotoga maritima (strain MSB8); E=2e-11 embl:CAC04498.1; (AL391588) putative two-component system; E=5e-11 COG: TM0468; COG0784 CheY-like receiver domains; E=2e-12 BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=3e-11 slr0322_3; COG0784 CheY-like receiver domains; E=3e-10 PFAM: PF00072; Response regulator receiver doma; E=9.1e-23.
  
     0.761
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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