STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmkCytidylate kinase; PMID: 9126287 best DB hits: BLAST: swissprot:Q49885; KCY_MYCLE CYTIDYLATE KINASE (CK) (CYTIDINE; E=2e-30 swissprot:Q9RC80; KCY_BACHD CYTIDYLATE KINASE (CK) (CYTIDINE; E=5e-30 pir:S75604; pantothenate synthetase panC - Synechocystis sp. (strain; E=3e-29 COG: BH1634; COG0283 Cytidylate kinase; E=5e-31 PFAM: PF02223; Thymidylate kinase; E=0.42 PF00485; Phosphoribulokinase / Uridine; E=0.094 PF01202; Shikimate kinase; E=3.5e-05. (229 aa)    
Predicted Functional Partners:
der
Probable GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
  
 0.987
ndk
Nucleoside diphosphate kinase (NDK); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.932
aroA-2
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
  
 0.926
nrdA
Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity).
  
 
 0.923
surE
Acid phosphatase SurE; PMID: 8905231 best DB hits: BLAST: swissprot:P73440; YE59_SYNY3 HYPOTHETICAL 24.9 KD PROTEIN SLL1459; E=4e-31 swissprot:O83434; SURE_TREPA STATIONARY-PHASE SURVIVAL PROTEIN; E=3e-22 gb:AAD51394.1; AF117715_3 (AF117715) survival protein homolog; E=4e-20 COG: sll1459; COG0496 Survival protein, predicted acid phosphatase; E=4e-32 PFAM: PF01975; Survival protein SurE; E=9.8e-49.
    
 0.918
surE-2
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.918
RB2543
30S ribosomal protein S1; PMID: 10871362 best DB hits: BLAST: swissprot:Q9Z8M3; RS1_CHLPN 30S RIBOSOMAL PROTEIN S1 -----; E=1e-139 swissprot:O84100; RS1_CHLTR 30S RIBOSOMAL PROTEIN S1 -----; E=1e-138 pir:A81710; ribosomal protein S1 TC0373 [imported] - Chlamydia; E=1e-137 COG: CPn0315; COG0539 Ribosomal protein S1; E=1e-140 PFAM: PF00575; S1 RNA binding domain; E=0.0018 PF01479; S4 domain; E=0.83 PF00575; S1 RNA binding domain; E=1.4e-24.
 
  
 0.916
lytB
LytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
      0.909
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
      0.908
RB1934
Alkaline phosphatase; PMID: 1712356 best DB hits: BLAST: pir:A47026; alkaline phosphatase, 145K - Synechococcus sp. (strain PCC; E=0.0 pir:S74916; alkaline phosphatase - Synechocystis sp. (strain PCC 6803); E=1e-108 pir:A69809; probable multifunctional phosphoesterase (EC 3.1.-.-) yfkN; E=5e-22 COG: sll0654_2; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase; E=8e-99 DRA0018; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and; E=1e-22 BS_yfkN_2; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase; E=4e-22 PFAM: PF01009; 5'-nucleotidase, catalytic do; E=1e-32 PF02872; 5 [...]
     
  0.900
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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