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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhASuccinate dehydrogenase subunit A; PMID: 98404057 best DB hits: BLAST: embl:CAA69872.1; (Y08563) succinate dehydrogenase subunit A; E=1e-175 ddbj:BAB06811.1; (AP001517) succinate dehydrogenase flavoprotein; E=1e-171 pir:A27763; succinate dehydrogenase (EC 1.3.99.1) flavoprotein -; E=1e-168 COG: BH3092; COG1053 Succinate dehydrogenase/fumarate reductase,; E=1e-172 PFAM: PF01494; FAD binding domain; E=0.0041 PF02032; Phytoene dehydrogenase related; E=0.46 PF00070; Pyridine nucleotide-disulphide; E=0.019. (669 aa)    
Predicted Functional Partners:
sdhC
Succinate dehydrogenase cytochrome B-558 subunit; PMID: 3086287 PMID: 3027051 PMID: 3036777 best DB hits: BLAST: swissprot:P08064; DHSC_BACSU SUCCINATE DEHYDROGENASE CYTOCHROME; E=2e-23 embl:CAA69871.1; (Y08563) succinate dehydrogenase subunit C; E=6e-20 ddbj:BAB06812.1; (AP001517) succinate dehydrogenase cytochrome; E=1e-19 COG: BS_sdhC; COG2009 Succinate dehydrogenase/fumarate reductase; E=2e-24.
 
 0.999
sdhB
Succinate dehydrogenase subunit B; PMID: 98404057 best DB hits: BLAST: embl:CAA69873.1; (Y08563) succinate dehydrogenase subunit B; E=6e-60 ddbj:BAB06810.1; (AP001517) succinate dehydrogenase iron-sulfur; E=1e-58 swissprot:P08066; DHSB_BACSU SUCCINATE DEHYDROGENASE IRON-SULFUR; E=2e-57 COG: BH3091; COG0479 Succinate dehydrogenase/fumarate reductase Fe-S; E=1e-59.
 
 0.999
sucC
succinyl-CoA synthetase (beta subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.990
sucD
Putative succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.990
fumC
Fumarate hydratase FumC; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.985
gabD
Succinate-semialdehyde dehydrogenase [NADP+]; PMID: 8297211 best DB hits: BLAST: swissprot:O32507; GABD_DEIRA SUCCINATE-SEMIALDEHYDE DEHYDROGENASE; E=1e-118 gb:AAD19405.1; (AF102543) succinic semialdehyde dehydrogenase; E=1e-111 swissprot:Q55585; GABD_SYNY3 PROBABLE SUCCINATE-SEMIALDEHYDE; E=1e-107 COG: DRA0343; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-119 PFAM: PF00171; Aldehyde dehydrogenase family; E=2.7e-118; Belongs to the aldehyde dehydrogenase family.
   
 0.916
RB4417
Cytochrome-c oxidase chain II/c precursor; PMID: 89231697 PMID: 91161592 best DB hits: BLAST: pir:A23711; cytochrome-c oxidase (EC 1.9.3.1) chain IIc precursor -; E=3e-42 swissprot:Q04441; COX2_BACFI CYTOCHROME C OXIDASE POLYPEPTIDE II; E=5e-38 ddbj:BAB06334.1; (AP001516) cytochrome caa3 oxidase (subunit II); E=2e-35 COG: BH2615_1; COG1622 Heme/copper-type cytochrome/quinol oxidases,; E=2e-21 XF1390; COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit; E=1e-14 slr1136; COG1622 Heme/copper-type cytochrome/quinol oxidases,; E=3e-14 PFAM: PF00116; Cytochrome C oxidase subunit II, [...]
   
 
 0.904
kdgA
Alpha-ketoglutarate dehydrogenase E1; PMID: 2404759 PMID: 2404760 best DB hits: BLAST: gb:AAC23516.1; (AF068740) alpha-ketoglutarate dehydrogenase; E1; E=0.0 swissprot:P20707; ODO1_AZOVI 2-OXOGLUTARATE DEHYDROGENASE E1; E=0.0 pir:G83448; 2-oxoglutarate dehydrogenase (E1 subunit) PA1585; E=0.0 COG: PA1585; COG0567 Pyruvate and 2-oxoglutarate dehydrogenases, E1; E=0.0 BH0776; COG1071 Thiamine pyrophosphate-dependent dehydrogenases, E1; E=3e-05 VNG2218G; COG0022 Thiamine pyrophosphate-dependent dehydrogenases,; E=0.008 PFAM: PF00676; Dehydrogenase E1 component; E=3.8e-40.
 
 0.884
aspC
Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147.
   
 0.852
gltA
Citrate synthase; PMID: 2337600 PMID: 6380576 best DB hits: BLAST: gb:AAF04133.1; AF191033_1 (AF191033) citrate synthase; E=1e-152 embl:CAB66275.1; (AL136519) citrate synthase. [Streptomyces; E=1e-149 swissprot:Q10530; CISY_MYCTU CITRATE SYNTHASE 1 ----- pir:; E=1e-145 COG: Rv0896; COG0372 Citrate synthase; E=1e-146 PFAM: PF00285; Citrate synthase; E=1e-208.
  
 
 0.832
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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