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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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pfkPPi-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (453 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; PMID: 2549364 best DB hits: BLAST: swissprot:P80860; G6PI_BACSU GLUCOSE-6-PHOSPHATE ISOMERASE (GPI); E=6e-53 ddbj:BAB07062.1; (AP001518) glucose-6-phosphate isomerase; E=4e-52 pir:S15937; glucose-6-phosphate isomerase (EC 5.3.1.9) - Bacillus; E=5e-52 COG: BS_pgi; COG0166 Glucose-6-phosphate isomerase; E=6e-54 PFAM: PF00342; Phosphoglucose isomerase; E=6.8e-31.
  
 0.978
fba
Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.931
tkt
Transketolase; PMID: 7859749 best DB hits: BLAST: swissprot:P45694; TKT_BACSU TRANSKETOLASE ----- pir: G69723; E=1e-171 ddbj:BAB06071.1; (AP001515) transketolase [Bacillus halodurans]; E=1e-169 swissprot:Q43848; TKTC_SOLTU TRANSKETOLASE, CHLOROPLAST PRECURSOR; E=1e-164 COG: BS_tkt; COG0021 Transketolase; E=1e-172 PFAM: PF00456; Transketolase, thiamine dipho; E=1.1e-160 PF02779; Transketolase, central domain; E=1.2e-77 PF02780; Transketolase, C-terminal dom; E=1.1e-49; Belongs to the transketolase family.
  
 0.921
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
  
 
 0.917
fbaB
Fructose-bisphosphate aldolase class I; PMID: 9531482 best DB hits: BLAST: pir:H64976; hypothetical protein b2097 - Escherichia coli (strain; E=1e-119 swissprot:P71295; ALF1_ECOLI FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS; E=1e-119 gb:AAB18249.1; (U73760) dehydrin [Escherichia coli]; E=1e-117 COG: fbaB; COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and; E=1e-120.
    
 0.917
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
   
 0.915
scrK
Probable fructokinase; PMID: 1809835 PMID: 10411273 best DB hits: BLAST: gb:AAG60871.1; AF322012_176 (AF322013) ID402 [Bradyrhizobium; E=5e-08 gb:AAK03933.1; (AE006222) unknown [Pasteurella multocida]; E=2e-06 pir:G75112; fructokinase (EC 2.7.1.4) PAB0482 - Pyrococcus abyssi; E=2e-05 COG: PAB0482; COG0524 Sugar kinases, ribokinase family; E=2e-06 PFAM: PF00294; pfkB family carbohydrate kinase; E=2.5e-12.
   
 0.911
pmi
PMID: 8293960 best DB hits: BLAST: pir:B75598; probable mannose-6-phosphate isomerase - Deinococcus; E=7e-43 pir:H69848; mannose-6-phosphate isomerase homolog yjdE - Bacillus; E=5e-39 ddbj:BAA75351.1; (AB011838) mannnose-6 phospate isomelase; E=8e-39 COG: DRA0048; COG1482 Phosphomannose isomerase; E=7e-44 PFAM: PF01238; Phosphomannose isomerase type I; E=0.0026.
     
 0.906
pfkA
PMID: 99287316 best DB hits: BLAST: pir:G72396; 6-phosphofructokinase, pyrophosphate-dependent -; E=1e-36 pir:S54978; 6-phosphofructokinase (EC 2.7.1.11),; E=9e-32 gb:AAA85791.1; (U11733) pyrophosphate-dependent; E=1e-31 COG: TM0289; COG0205 6-phosphofructokinase; E=1e-37 PFAM: PF00365; Phosphofructokinase; E=0.0021.
  
  
 
0.905
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.752
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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