STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB10652Probable C-methyltransferase; PMID: 10660060 best DB hits: BLAST: gb:AAD55584.1; (AF077869) C-methyltransferase [Streptomyces; E=4e-09 gb:AAG15232.1; AF288602_4 (AF288602) CrtF [Chloroflexus; E=4e-07 pir:T34921; probable methyltransferase - Streptomyces coelicolor; E=2e-06 COG: Rv0089; COG0500 SAM-dependent methyltransferases; E=7e-04 DR2405; COG2226 Methylase involved in ubiquinone/menaquinone; E=0.002. (341 aa)    
Predicted Functional Partners:
nifS
nifS protein; Best DB hits: BLAST: gb:AAK05889.1; AE006408_13 (AE006408) conserved hypothetical; E=2e-16 pir:A72506; probable tRNA splicing protein SPL1 APE2023 - Aeropyrum; E=3e-17 pir:F65063; hypothetical protein b2810 - Escherichia coli (strain; E=8e-18 COG: BB0084; COG0520 Selenocysteine lyase; E=2e-13 yfhO; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; E=1e-14 BS_ycbU; COG0520 Selenocysteine lyase; E=2e-15 PFAM: PF00266; Aminotransferase class-V; E=1.5e-05.
  
    0.779
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
       0.774
RB10655
Best DB hits: BLAST: pir:G83352; transcription regulator MtlR PA2337 [imported] -; E=1e-09 pir:S52856; AraC-like protein - Azorhizobium caulinodans -----; E=1e-08 gb:AAF43900.1; (U20115) adpA-like protein [Mycobacterium; E=2e-08 COG: PA2337; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-10 BS_adaA; COG2169 Adenosine deaminase; E=1e-05 araC; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-05 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=1.4e-21.
       0.773
hioM
Hydroxyindole O-methyltransferase; PMID: 1544900 best DB hits: BLAST: swissprot:P10950; HIOM_BOVIN HYDROXYINDOLE O-METHYLTRANSFERASE; E=1e-48 swissprot:Q92056; HIOM_CHICK HYDROXYINDOLE O-METHYLTRANSFERASE; E=3e-48 embl:CAA75675.1; (Y15521) start position 1 [Homo sapiens]; E=5e-47 COG: Rv0567; COG0500 SAM-dependent methyltransferases; E=7e-32 PFAM: PF01047; MarR family; E=0.1 PF01022; Bacterial regulatory protein,; E=0.82 PF00891; O-methyltransferase; E=7.5e-53.
  
     0.769
RB11975
Polyketide synthase; PMID: 10662695 PMID: 10649995 best DB hits: BLAST: gb:AAF26921.1; AF210843_18 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF26923.1; AF210843_20 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=0.0 COG: BS_fabD; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=7e-31 PA2965; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase I; E=3e-28 PA5234; COG0604 NADPH:quinone reductase and related Zn-dependent; E=2e-27 PFAM: PF00108; Thiolase, N-terminal domain; E=7.3e-07 PF00109; Beta-ketoacyl s [...]
 
 
 
 0.571
RB6500
Mycocerosate synthase; PMID: 3880746 best DB hits: BLAST: pir:S72705; mycocerosate synthase (EC 2.3.1.111) - Mycobacterium; E=0.0 pir:H70819; probable polyketide synthase - Mycobacterium tuberculosis; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=1e-180 COG: PA2402_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=4e-99 BS_ppsD_3; COG1020 Non-ribosomal peptide synthetase modules and; E=4e-92 PA2424_2; COG1020 Non-ribosomal peptide synthetase modules and related; E=1e-91 PFAM: PF00108; Thiolase, N-terminal domain; E=2.7e-06 PF00109; Beta-keto [...]
 
 
 
 0.547
trpB
Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.529
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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