Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
hsdMType I restriction enzyme StySPI M protein; PMID: 1409708 PMID: 3025838 best DB hits: BLAST: swissprot:P07989; T1M_SALPO TYPE I RESTRICTION ENZYME STYSPI M; E=1e-135 gb:AAA23985.1; (L02508) restriction-modification enzyme type I M; E=1e-134 swissprot:P08957; T1MK_ECOLI TYPE I RESTRICTION ENZYME ECOKI M; E=1e-134 COG: hsdM; COG0286 Type I restriction-modification system; E=1e-135 PFAM: PF02506; Type I restriction modification s; E=0.00016 PF02384; N-6 DNA Methylase; E=7.2e-40. (507 aa)    
Predicted Functional Partners:
hsdS
PMID: 2642743 best DB hits: BLAST: swissprot:P19705; T1SE_ECOLI TYPE I RESTRICTION ENZYME ECOEI; E=5e-22 swissprot:P05719; T1SK_ECOLI TYPE I RESTRICTION ENZYME ECOKI; E=2e-18 swissprot:P06990; T1SB_ECOLI TYPE I RESTRICTION ENZYME ECOBI; E=1e-16 COG: hsdS; COG0732 Restriction endonuclease S subunits; E=1e-19 PFAM: PF01420; Type I restriction modification D; E=4.3e-18.
 
 0.982
hsdR
Type I restriction enzyme EcoKI R protein; PMID: 3323532 PMID: 1650347 best DB hits: BLAST: swissprot:P08956; T1RK_ECOLI TYPE I RESTRICTION ENZYME ECOKI R; E=0.0 embl:CAA29791.1; (X06545) hsdR gene product (AA 1 - 1090); E=1e-158 gb:AAF43698.1; AF232829_1 (AF232829) unknown [Mycobacterium avium]; E=8e-38 COG: hsdR; COG0610 Restriction enzymes type I helicase subunits and related; E=0.0 YDR332w; COG1061 DNA or RNA helicases of superfamily II; E=7e-14 jhp1424; COG0610 Restriction enzymes type I helicase subunits and; E=3e-04 PFAM: PF00270; DEAD/DEAH box helicase; E=0.047 PF00271; Helicas [...]
 
 
 0.958
hsdS-4
PMID: 6304321 best DB hits: BLAST: pir:B64316; restriction modification system S chain homolog -; E=8e-25 pir:G82522; type I restriction-modification system specificity; E=3e-22 pir:C82823; type I restriction-modification system specificity; E=4e-22 COG: MJ0130m; COG0732 Restriction endonuclease S subunits; E=8e-26 PFAM: PF01420; Type I restriction modification D; E=2.6e-32.
 
 0.876
hsdS-2
Probable HsdS polypeptide, part of CfrA family; PMID: 2585490 PMID: 9837717 best DB hits: BLAST: gb:AAC37110.1; (L77118) M. jannaschii predicted coding region; E=3e-12 swissprot:Q58615; YC18_METJA HYPOTHETICAL PROTEIN MJ1218 -----; E=3e-12 embl:CAA35604.1; (X17591) HsdS polypeptide, part of CfrA family; E=1e-06 COG: MJECL41; COG0732 Restriction endonuclease S subunits; E=3e-13 PFAM: PF01420; Type I restriction modification; E=0.00019.
 
 
 0.850
hsdR-2
HsdR; Subunit R is required for both nuclease and ATPase activities, but not for modification.
 
  
 0.825
RB11619
PMID: 6304321 best DB hits: BLAST: gb:AAG18734.1; (AE004978) type I restriction modification enzyme,; E=6e-23 swissprot:P06990; T1SB_ECOLI TYPE I RESTRICTION ENZYME ECOBI; E=8e-16 pir:B64316; restriction modification system S chain homolog -; E=2e-12 COG: VNG0107G; COG0732 Restriction endonuclease S subunits; E=6e-24 PFAM: PF01420; Type I restriction modification; E=1.6e-10.
 
 
 0.821
hsdS-3
Probable Type I restriction enzyme EcoBI specificity protein; PMID: 6304321 best DB hits: BLAST: embl:CAA10700.1; (AJ132566) HsdS protein [Escherichia coli]; E=5e-13 swissprot:P06990; T1SB_ECOLI TYPE I RESTRICTION ENZYME ECOBI; E=2e-10 gb:AAG18734.1; (AE004978) type I restriction modification enzyme,; E=4e-09 COG: VNG0107G; COG0732 Restriction endonuclease S subunits; E=4e-10 PFAM: PF01420; Type I restriction modification D; E=3.3e-06.
  
 
 0.622
hsdR-3
PMID: 8412658 best DB hits: BLAST: swissprot:Q07736; T1RA_ECOLI TYPE I RESTRICTION ENZYME ECOAI R; E=3e-33 gb:AAG59531.1; AE005666_3 (AE005666) putative restriction; E=3e-33 swissprot:P08956; T1RK_ECOLI TYPE I RESTRICTION ENZYME ECOKI R; E=4e-29 COG: hsdR; COG0610 Restriction enzymes type I helicase subunits and; E=4e-30 YDR332w; COG1061 DNA or RNA helicases of superfamily II; E=2e-09 MJECL40; COG0610 Restriction enzymes type I helicase subunits and; E=0.001 PFAM: PF00270; DEAD/DEAH box helicase; E=0.14 PF00271; Helicase conserved C-terminal doma; E=0.6.
 
 
 0.591
RB10772
Hypothetical protein.
       0.508
RB10774
Hypothetical protein-transmembrane prediction.
       0.459
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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