Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RB10787Conserved hypothetical protein-putative glycerate kinase; Best DB hits: BLAST: pir:A72236; hypothetical protein TM1585 - Thermotoga maritima; E=8e-33 pir:B71162; hypothetical protein PH0495 - Pyrococcus horikoshii; E=6e-30 swissprot:Q44472; TUD4_AGRVI PUTATIVE HYDROXYPYRUVATE REDUCTASE; E=5e-29 COG: TM1585; COG2379 Putative glycerate kinase; E=8e-34. (487 aa)    
Predicted Functional Partners:
RB6394
Probable 2-hydroxyacid dehydrogenase; PMID: 10984043 best DB hits: BLAST: gb:AAH00605.1; AAH00605 (BC000605) glyoxylate; E=1e-66 ref:XP_005487.2; glyoxylate reductasehydroxypyruvate reductase; E=1e-66 gb:AAF51963.1; (AE003602) CG1236 gene product [Drosophila; E=7e-61 COG: APE1831; COG1052 Lactate dehydrogenase and related dehydrogenases; E=2e-60 PAB0514; COG0111 Phosphoglycerate dehydrogenase and related; E=3e-44 YNL274c; COG1052 Lactate dehydrogenase and related dehydrogenases; E=3e-34 PFAM: PF00389; D-isomer specific 2-hydroxyacid; E=2.4e-06 PF02826; D-isomer specific 2-hydroxyacid; [...]
 
 0.958
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.924
pgm
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
  0.901
RB10172
Aldehyde dehydrogenase; PMID: 9369242 best DB hits: BLAST: gb:AAA64636.1; (U07235) aldehyde dehydrogenase [Mus musculus]; E=1e-163 gb:AAA51693.1; (M20456) aldehyde dehydrogenase [Homo sapiens]; E=1e-163 pir:DEHUE2; aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) 2 precursor,; E=1e-162 COG: BH0539; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-156 PFAM: PF00171; Aldehyde dehydrogenase family; E=1.5e-240; Belongs to the aldehyde dehydrogenase family.
     
  0.900
RB6467
PMID: 9537320 best DB hits: BLAST: pir:A70471; phosphoglycerate mutase 1 - Aquifex aeolicus -----; E=0.006 pir:G69831; phosphoglycerate mutase (glycolysis) homolog yhfR -; E=0.012 embl:CAA99510.1; (Z75191) ORF YOR283w [Saccharomyces; E=0.021 COG: aq_1990; COG0406 Phosphoglycerate; E=6e-04 BS_yhfR; COG0406 Phosphoglycerate mutase/fructose-2,6-bisphosphatase; E=0.001 YOR283w; COG0406 Phosphoglycerate; E=0.002 PFAM: PF00300; Phosphoglycerate mutase family; E=3.9e-05.
     
  0.900
RB683
Aldehyde dehydrogenase; PMID: 7484410 best DB hits: BLAST: gb:AAF52769.1; (AE003624) CG3752 gene product [Drosophila; E=5e-73 ddbj:BAA34785.1; (AB015226) RALDH2 [Homo sapiens]; E=2e-72 swissprot:O94788; DHAS_HUMAN RETINALDEHYDE-SPECIFIC DEHYDROGENASE; E=2e-72 COG: YOR374w; COG1012 NAD-dependent aldehyde dehydrogenases; E=2e-71 PFAM: PF00171; Aldehyde dehydrogenase family; E=7e-156.
     
  0.900
bcpC
Best DB hits: BLAST: pir:D69154; probable phosphonopyruvate decarboxylase (EC 4.1.1.-) 1; E=3e-86 gb:AAB89821.1; (AE001005) phosphonopyruvate decarboxylase; E=2e-64 pir:D69079; phosphonopyruvate decarboxylase (EC 4.1.1.-) -; E=7e-48 COG: MTH418; COG1015 Phosphopentomutase/predicted phosphoglycerate mutase; E=3e-87 MTH1591; COG1015 Phosphopentomutase/predicted phosphoglycerate; E=7e-49 MJ1612; COG1015 Phosphopentomutase/predicted phosphoglycerate mutase; E=2e-47 PFAM: PF02023; SCAN domain; E=0.75 PF01676; Metalloenzyme superfamily; E=4.3e-29.
     
  0.900
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
  
 
 0.846
ldh
L-lactate dehydrogenase; PMID: 3122782 PMID: 3118900 best DB hits: BLAST: swissprot:P00345; LDH_BACME L-LACTATE DEHYDROGENASE -----pir:; E=3e-49 swissprot:P20619; LDHX_BACPS L-LACTATE DEHYDROGENASE X -----; E=6e-47 swissprot:P16115; LDH_THEMA L-LACTATE DEHYDROGENASE ----- pir:; E=3e-46 COG: TM1867; COG0039 Malate/lactate dehydrogenases; E=2e-47 PFAM: PF00056; lactate/malate dehydrogenase, NA; E=6.7e-46 PF02866; lactate/malate dehydrogenase, al; E=2.4e-36; Belongs to the LDH/MDH superfamily.
     
 0.822
ldh-2
L-lactate/malate dehydrogenase; PMID: 8404889 PMID: 3098260 best DB hits: BLAST: swissprot:P16115; LDH_THEMA L-LACTATE DEHYDROGENASE -----pir:; E=2e-51 pdb:1A5Z; Lactate Dehydrogenase From Thermotoga Maritima; E=2e-51 pdb:1LLC; L-Lactate Dehydrogenase (E.C.1.1.1.27) Complex With; E=9e-49 COG: TM1867; COG0039 Malate/lactate dehydrogenases; E=2e-52 PFAM: PF00056; lactate/malate dehydrogenase, NA; E=7.5e-36 PF02866; lactate/malate dehydrogenase, al; E=5e-36; Belongs to the LDH/MDH superfamily.
     
 0.822
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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