STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lysSlysyl-tRNA synthetase; Best DB hits: BLAST: swissprot:Q53638; SYK_STAAU LYSYL-TRNA SYNTHETASE (LYSINE--TRNA; E=1e-116 swissprot:P37477; SYK_BACSU LYSYL-TRNA SYNTHETASE (LYSINE--TRNA; E=1e-114 swissprot:Q9KGG4; SYK_BACHD LYSYL-TRNA SYNTHETASE (LYSINE--TRNA; E=1e-111 COG: BS_lysS; COG1190 Lysyl-tRNA synthetase class II; E=1e-115 PFAM: PF01336; OB-fold nucleic acid binding dom; E=5.9e-12 PF01409; tRNA synthetases class II (F); E=0.46 PF00152; tRNA synthetases class II (D, K; E=7e-136; Belongs to the class-II aminoacyl-tRNA synthetase family. (546 aa)    
Predicted Functional Partners:
argS
arginyl-tRNA synthetase; PMID: 2668891 best DB hits: BLAST: pir:G82121; arginyl-tRNA synthetase VC2074 [imported] - Vibrio; E=1e-69 swissprot:Q55486; SYR_SYNY3 ARGINYL-TRNA SYNTHETASE; E=5e-68 embl:CAC01600.1; (AJ269505) putative arginyl-tRNA synthetase; E=4e-66 COG: VC2074; COG0018 Arginyl-tRNA synthetase; E=1e-70 PFAM: PF00750; tRNA synthetases class I (R); E=5.7e-55.
 
 0.981
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 0.965
proS
Prolyl tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
  
 0.964
ileS
Probable isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 0.962
lueS
Putative leucyl-tRNA synthetase; PMID: 1317842 best DB hits: BLAST: ddbj:BAB17162.1; (AP002868) putative leucyl-tRNA synthetase; E=0.0 embl:CAB77903.1; (AL161500) putative leucyl tRNA synthetase; E=0.0 gb:AAK04914.1; AE006315_3 (AE006315) leucyl-tRNA synthetase (EC; E=0.0 COG: TP0586; COG0495 Leucyl-tRNA synthetase; E=0.0 PFAM: PF00133; tRNA synthetases class I (I, L; E=1.4e-39; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 0.945
guaA-2
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.944
asnS
asparaginyl-tRNA synthetase; PMID: 2693216 PMID: 1425658 PMID: 2009959 PMID: 1544480 best DB hits: BLAST: swissprot:P52276; SYN_SYNY3 PROBABLE ASPARAGINYL-TRNA SYNTHETASE; E=1e-151 gb:AAK02727.1; (AE006100) AsnS [Pasteurella multocida]; E=1e-150 pir:E82217; asparaginyl-tRNA synthetase VC1297 [imported] - Vibrio; E=1e-148 COG: sll0495; COG0017 Aspartyl/asparaginyl-tRNA synthetases; E=1e-152 PFAM: PF01336; OB-fold nucleic acid binding dom; E=6.8e-15 PF01409; tRNA synthetases class II (F); E=0.025 PF00152; tRNA synthetases class II (D, K; E=1.3e-132.
   
 0.911
rspB
Ribosomal protein S2; PMID: 6806564 PMID: 6272196 PMID: 7023985 PMID: 10094780 best DB hits: BLAST: pir:F75386; ribosomal protein S2 - Deinococcus radiodurans (strain; E=9e-52 swissprot:Q9WZM1; RS2_THEMA 30S RIBOSOMAL PROTEIN S2 -----; E=2e-51 pdb:1FJF; B Chain B, Structure Of The Thermus Thermophilus 30s; E=2e-50 COG: DR1513; COG0052 Ribosomal protein S2; E=8e-53 PFAM: PF00318; Ribosomal protein S2; E=1.2e-82; Belongs to the universal ribosomal protein uS2 family.
  
 
 0.910
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
 
 0.888
gluQ
glutamyl-tRNA synthetase-related protein; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
 
 0.885
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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