Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dltEBest DB hits: BLAST: pir:H83564; probable short-chain dehydrogenase PA0658 [imported] -; E=1e-42 pir:E70761; probable ketoacyl reductase - Mycobacterium tuberculosis; E=8e-38 gb:AAK03000.1; (AE006130) unknown [Pasteurella multocida]; E=4e-34 COG: PA0658; COG0300 Short-chain dehydrogenases of various substrate; E=1e-43 Rv1050; COG1028 Dehydrogenases with different specificities (related; E=5e-23 YMR226c; COG0300 Short-chain dehydrogenases of various substrate; E=2e-22 PFAM: PF00106; short chain dehydrogenase; E=1.6e-45; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (303 aa)    
Predicted Functional Partners:
RB10973
Hypothetical protein.
       0.773
RB6327
PMID: 10617197 best DB hits: BLAST: ddbj:BAA98195.1; (AP002030) short chain alcohol; E=7e-21 gb:AAC95219.1; (AC004561) putative tropinone reductase; E=5e-20 gb:AAC95202.1; (AC004561) putative tropinone reductase; E=1e-19 COG: TM1724; COG1028 Dehydrogenases with different specificities (related; E=4e-19 VNG1341G; COG1028 Dehydrogenases with different specificities; E=2e-16 TM0441; COG1028 Dehydrogenases with different specificities (related; E=1e-15 PFAM: PF00899; ThiF family; E=0.21 PF02254; KTN NAD-binding domain; E=0.066 PF00106; short chain dehydrogenase; E=3.9e-28.
  
 
   0.668
RB8728
Putative oxidoreductase; Best DB hits: BLAST: gb:AAC15079.1; (L37087) oxidoreductase [Nostoc sp.]; E=1e-59 ddbj:BAB04786.1; (AP001510) D-mannonate oxidoreductase [Bacillus; E=2e-54 pir:H69852; 2-deoxy-D-gluconate 3-dehydrogenase homolog yjmF -; E=2e-51 COG: BH1067; COG1028 Dehydrogenases with different specificities (related; E=2e-55 BS_yjmF; COG1028 Dehydrogenases with different specificities; E=2e-52 BH0707; COG1028 Dehydrogenases with different specificities (related; E=7e-51 PFAM: PF00106; short chain dehydrogenase; E=1.9e-37 PF00678; Short chain dehydrogenase/reduct; E=8.8e-10.
  
 
   0.613
RB10967
Putative oxidoreductase; Best DB hits: BLAST: embl:CAB62729.1; (AL133423) putative oxidoreductase [Streptomyces; E=1e-81 gb:AAG19273.1; (AE005023) quinone oxidoreductase; YfmJ; E=1e-77 pir:A69813; quinone oxidoreductase homolog yfmJ - Bacillus subtilis; E=6e-76 COG: VNG0815G; COG2130 Putative NADP-dependent oxidoreductases; E=1e-78 PA5234; COG0604 NADPH:quinone reductase and related Zn-dependent; E=5e-10 Ta0841; COG1064 Zn-dependent alcohol dehydrogenases; E=2e-05 PFAM: PF00022; Actin; E=0.28 PF00107; Zinc-binding dehydrogenases; E=7.7e-37.
  
  
 0.568
RB10974
Hypothetical protein.
       0.564
gabD
Succinate-semialdehyde dehydrogenase [NADP+]; PMID: 8297211 best DB hits: BLAST: swissprot:O32507; GABD_DEIRA SUCCINATE-SEMIALDEHYDE DEHYDROGENASE; E=1e-118 gb:AAD19405.1; (AF102543) succinic semialdehyde dehydrogenase; E=1e-111 swissprot:Q55585; GABD_SYNY3 PROBABLE SUCCINATE-SEMIALDEHYDE; E=1e-107 COG: DRA0343; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-119 PFAM: PF00171; Aldehyde dehydrogenase family; E=2.7e-118; Belongs to the aldehyde dehydrogenase family.
       0.561
RB11975
Polyketide synthase; PMID: 10662695 PMID: 10649995 best DB hits: BLAST: gb:AAF26921.1; AF210843_18 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF26923.1; AF210843_20 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=0.0 COG: BS_fabD; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=7e-31 PA2965; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase I; E=3e-28 PA5234; COG0604 NADPH:quinone reductase and related Zn-dependent; E=2e-27 PFAM: PF00108; Thiolase, N-terminal domain; E=7.3e-07 PF00109; Beta-ketoacyl s [...]
  
 
 0.539
RB10446
Beta keto-acyl synthase; Best DB hits: BLAST: ddbj:BAA89384.1; (AB025342) ORF10 [Moritella marina]; E=3e-37 pir:T30185; hypothetical protein 7 - Shewanella sp ----- gb:; E=3e-36 pir:T37057; probable multi-domain beta keto-acyl synthase -; E=8e-35 COG: DR1945; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=3e-17 Rv3391_1; COG0451 Nucleoside-diphosphate-sugar epimerases; E=2e-14 BH2492; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=2e-13 PFAM: PF00109; Beta-ketoacyl synthase, N-ter; E=7.7e-09 PF02801; Beta-ketoacyl synthase, C-ter; E=7.6e-61 PF00109; Beta-ketoacyl syntha [...]
 
 
 0.538
RB6500
Mycocerosate synthase; PMID: 3880746 best DB hits: BLAST: pir:S72705; mycocerosate synthase (EC 2.3.1.111) - Mycobacterium; E=0.0 pir:H70819; probable polyketide synthase - Mycobacterium tuberculosis; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=1e-180 COG: PA2402_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=4e-99 BS_ppsD_3; COG1020 Non-ribosomal peptide synthetase modules and; E=4e-92 PA2424_2; COG1020 Non-ribosomal peptide synthetase modules and related; E=1e-91 PFAM: PF00108; Thiolase, N-terminal domain; E=2.7e-06 PF00109; Beta-keto [...]
  
 
 0.536
yqhK
Probable glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
 
      0.508
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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