Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ntrBProbable nitrogen regulation protein ntrB; PMID: 7553451 best DB hits: BLAST: pir:A82630; two-component system, sensor protein XF1849 [imported] -; E=1e-11 pir:S35265; ntrB protein - Azospirillum brasilense ----- embl:; E=1e-11 swissprot:P45670; NTRB_AZOBR NITROGEN REGULATION PROTEIN NTRB; E=3e-11 COG: XF1849; COG0642 Sensory transduction histidine kinases; E=1e-12 PFAM: PF00672; HAMP domain; E=9.9e-11 PF00512; His Kinase A (phosphoacceptor) doma; E=0.00015 PF02518; Histidine kinase-, DNA gyrase B-, p; E=4.8e-20. (493 aa)    
Predicted Functional Partners:
ntrC
Nitrogen regulation protein NR(I); PMID: 7602583 PMID: 7827089 PMID: 10512705 PMID: 10622255 best DB hits: BLAST: pir:E83006; two-component response regulator NtrC PA5125 [imported]; E=9e-89 swissprot:P41789; NTRC_SALTY NITROGEN REGULATION PROTEIN NR(I); E=1e-85 gb:AAG59057.1; AE005617_6 (AE005617) response regulator for gln; E=2e-85 COG: PA5125; COG2204 AAA superfamily ATPases with N-terminal receiver; E=8e-90 PFAM: PF00072; Response regulator receiver doma; E=1e-31 PF00158; Sigma-54 interaction domain; E=2.1e-114.
 
   0.905
atoS-2
Sensor protein atoS; PMID: 8346225 best DB hits: BLAST: swissprot:Q06067; ATOS_ECOLI SENSOR PROTEIN ATOS ----- pir:; E=1e-26 gb:AAF33505.1; (AF170176) Salmonella typhimurium sensor protein; E=3e-25 gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=1e-24 COG: atoS_3; COG0642 Sensory transduction histidine kinases; E=1e-27 PFAM: PF00072; Response regulator receiver doma; E=2.2e-12 PF00989; PAS domain; E=1.6e-06 PF00785; PAC motif; E=0.00084.
 
 
 0.811
RB641
Sensory histidine protein kinase; Best DB hits: BLAST: pir:G82753; two-component system, sensor protein XF0853 [imported] -; E=2e-41 gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=8e-39 pir:A82300; sensory box sensor histidine kinaseresponse regulator; E=4e-34 COG: XF0853; COG0642 Sensory transduction histidine kinases; E=2e-42 sll0779_1; COG2202 PAS/PAC domain; E=1e-23 VCA0736_1; COG0642 Sensory transduction histidine kinases; E=1e-23 PFAM: PF00785; PAC motif; E=8.5e-08 PF00989; PAS domain; E=0.013 PF00785; PAC motif; E=0.1.
 
 
 
 0.735
RB8274
Sensor protein atoS; PMID: 8346225 PMID: 9097040 best DB hits: BLAST: swissprot:Q06067; ATOS_ECOLI SENSOR PROTEIN ATOS -----pir:; E=2e-17 gb:AAD47419.1; AF100457_2 (AF100457) histidine kinase [Myxococcus; E=2e-16 ddbj:BAB04255.1; (AP001508) two-component sensor histidine kinase; E=3e-14 COG: atoS_3; COG0642 Sensory transduction histidine kinases; E=2e-18 Rv1827; COG1716 FHA-domain-containing proteins; E=1e-08 PA2882; COG0642 Sensory transduction histidine kinases; E=2e-08 PFAM: PF00498; FHA domain; E=3.2e-19 PF01590; GAF domain; E=4.8e-18 PF00512; His Kinase A (phosphoacceptor) doma; E [...]
 
 
 
 0.734
RB4760
Probable sporulation initiation phosphotransferase F; PMID: 3003689 PMID: 2997779 best DB hits: BLAST: pdb:1SRR; A Chain A, Crystal Structure Of A Phosphatase Resistant; E=3e-12 swissprot:P06628; SP0F_BACSU SPORULATION INITIATION; E=5e-12 pdb:1F51; E Chain E, A Transient Interaction Between Two; E=8e-12 COG: BS_spo0F; COG0784 CheY-like receiver domains; E=4e-13 PA4381; COG0745 Response regulators consisting of a CheY-like; E=5e-11 rcsC_3; COG0784 CheY-like receiver domains; E=5e-11 PFAM: PF00072; Response regulator receiver doma; E=2.5e-23 PF02310; B12 binding domain; E=0.14 PF00072; R [...]
  
   0.723
hydH-3
Sensor protein HYDH; PMID: 2666400 best DB hits: BLAST: swissprot:P14377; HYDH_ECOLI SENSOR PROTEIN HYDH ----- pir:; E=5e-19 gb:AAG59200.1; AE005632_1 (AE005632) sensor kinase for HydG,; E=6e-18 swissprot:P07168; VIRA_AGRT6 WIDE HOST RANGE VIRA PROTEIN (WHR; E=6e-18 COG: hydH; COG0642 Sensory transduction histidine kinases; E=5e-20 PFAM: PF00512; His Kinase A (phosphoacceptor) doma; E=1.1e-06 PF02518; Histidine kinase-, DNA gyrase B-, p; E=4e-35.
  
 
   0.720
hydH-2
Probable sensor protein (HYDH)-putative sensory transduction histidine kinases; PMID: 2666400 PMID: 11243806 best DB hits: BLAST: gb:AAF33505.1; (AF170176) Salmonella typhimurium sensor protein; E=1e-13 gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=2e-13 pir:S70528; sensor protein pilS - Myxococcus xanthus ----- gb:; E=4e-13 COG: BH3477; COG0642 Sensory transduction histidine kinases; E=2e-13 PFAM: PF00512; His Kinase A (phosphoacceptor) doma; E=2e-11 PF02518; Histidine kinase-, DNA gyrase B-, p; E=2.9e-21.
  
 
   0.719
RB12326
Sensory histidine protein kinase; PMID: 11406410 best DB hits: BLAST: gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=2e-45 pir:F83153; probable two-component sensor PA3946 [imported] -; E=3e-36 pir:E83265; probable two-component sensor PA3044 [imported] -; E=2e-35 COG: PA3044; COG0642 Sensory transduction histidine kinases; E=2e-36 PFAM: PF01590; GAF domain; E=3.2e-20 PF00989; PAS domain; E=1.2e-07 PF00512; His Kinase A (phosphoacceptor) d; E=4.8e-16.
 
 
 
 0.689
phoB
Probable regulatory components of sensory transduction system; PMID: 8905231 best DB hits: BLAST: embl:CAA11074.1; (AJ223073) phosphate regulatory protein; E=3e-11 pir:B70152; response regulatory protein (rrp-1) homolog - Lyme; E=1e-10 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=2e-10 COG: BB0419_1; COG0784 CheY-like receiver domains; E=1e-11 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-10 slr1305_1; COG0784 CheY-like receiver domains; E=3e-09 PFAM: PF00072; Response regulator receiver doma; E=1.4e-18.
  
 
   0.685
RB5479
Probable sensory transduction histidine kinase; PMID: 3142862 best DB hits: BLAST: swissprot:P23545; PHOR_BACSU ALKALINE PHOSPHATASE SYNTHESIS SENSOR; E=1e-28 pir:S75514; sensory transduction histidine kinase slr1324 -; E=2e-27 pir:E83529; sensorresponse regulator hybrid PA0928 [imported] -; E=6e-25 COG: BS_phoR_3; COG0642 Sensory transduction histidine kinases; E=1e-29 PFAM: PF00072; Response regulator receiver do; E=4.5e-14 PF00512; His Kinase A (phosphoacceptor); E=6.3e-16 PF02518; Histidine kinase-, DNA gyrase; E=5.3e-31.
 
 
 
 0.676
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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