STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
acrBAcriflavine resistance protein B; PMID: 8905231 PMID: 8407802 PMID: 7651136 best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:D83206; probable RND efflux transporter PA3522 [imported] -; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1072 aa)    
Predicted Functional Partners:
acrA
Acriflavine resistance protein A [Precursor]; PMID: 10984043 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=1e-54 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-52 pir:E83206; probable RND efflux membrane fusion protein precursor; E=2e-42 COG: PA2493; COG0845 Membrane-fusion protein; E=1e-55 PFAM: PF00364; Biotin-requiring enzyme; E=0.0006 PF00529; HlyD family secretion protein; E=4e-20; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.957
ibeB-2
Probable outer membrane lipoprotein IbeB; PMID: 99242786 best DB hits: BLAST: gb:AAD30205.1; (AF094824) IbeB [Escherichia coli]; E=3e-33 swissprot:P77211; IBEB_ECOLI PROBABLE OUTER MEMBRANE LIPOPROTEIN; E=4e-33 gb:AAG54905.1; AE005237_1 (AE005237) putative resistance protein; E=1e-32 COG: ylcB; COG1538 Outer membrane protein; E=4e-34 PFAM: PF02321; Outer membrane efflux protein; E=1.3e-09.
   0.919
mexE
PMID: 8196548 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=9e-33 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-31 embl:CAC14594.1; (AJ252200) putative membrane fusion protein; E=1e-21 COG: PA2493; COG0845 Membrane-fusion protein; E=9e-34 PFAM: PF00364; Biotin-requiring enzyme; E=0.31 PF00529; HlyD family secretion protein; E=5.5e-13; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
   0.819
mexA
Multidrug resistance protein MexA; PMID: 7968531 best DB hits: BLAST: gb:AAD12178.1; (AF029405) periplasmic linker protein [Pseudomonas; E=8e-20 swissprot:P37636; YHIU_ECOLI HYPOTHETICAL 41.2 KD LIPOPROTEIN IN; E=3e-19 gb:AAG58654.1; AE005576_13 (AE005576) putative membrane protein; E=4e-19 COG: yhiU; COG0845 Membrane-fusion protein; E=3e-20 PFAM: PF00364; Biotin-requiring enzyme; E=0.0015 PF00529; HlyD family secretion protein; E=3.1e-06; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.799
ibeB
PMID: 10225861 best DB hits: BLAST: pir:A83347; probable outer membrane protein PA2391 [imported] -; E=1e-24 pir:F83329; probable outer membrane lipoprotein precursor PA2525; E=2e-23 gb:AAD05185.1; (AF110185) unknown [Burkholderia pseudomallei]; E=4e-23 COG: PA2391; COG1538 Outer membrane protein; E=1e-25 PFAM: PF02321; Outer membrane efflux protein; E=1.3e-18.
   0.792
czcB
Cobalt-zinc-cadmium resistance protein; PMID: 2249654 PMID: 2184029 best DB hits: BLAST: gb:AAG09628.1; (AY007258) CztB [Pseudomonas fluorescens]; E=6e-17 pir:F83330; RND divalent metal cation efflux membrane fusion protein; E=2e-15 embl:CAB56470.1; (Y14018) czrB protein [Pseudomonas aeruginosa]; E=2e-14 COG: PA2521; COG0845 Membrane-fusion protein; E=1e-16 PFAM: PF00364; Biotin-requiring enzyme; E=4.2e-05 PF00529; HlyD family secretion protein; E=0.37; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
   0.631
RB13157
Mucin-desulfating sulfatase; PMID: 9710560 PMID: 10809675 best DB hits: BLAST: gb:AAF72520.1; AF248951_1 (AF248951) mucin-desulfating sulfatase; E=6e-35 gb:AAF55296.1; (AE003712) Sulf1 gene product [Drosophila; E=2e-28 pir:T16584; hypothetical protein K09C4.8 - Caenorhabditis elegans; E=3e-24 COG: yidJ; COG3119 Arylsulfatase A and related enzymes; E=1e-24 BS_yqgS; COG1368 Phosphoglycerol transferase and related proteins,; E=0.007 PFAM: PF02455; Hexon-associated protein (IIIa); E=0.25 PF00884; Sulfatase; E=8e-47.
      
 0.618
RB2135
Heparan N-sulfatase; PMID: 11181566 best DB hits: BLAST: gb:AAG41945.1; AF304053_1 (AF304053) heparan N-sulfatase [Mus; E=4e-62 gb:AAF29467.1; (AF156255) N-sulfoglucosamine sulfohydrolase [Mus; E=6e-62 gb:AAG41946.1; AF304054_1 (AF304054) mutant heparan N-sulfatase; E=1e-61 COG: Rv0296c; COG3119 Arylsulfatase A and related enzymes; E=7e-23 PAB0793; COG2194 Predicted membrane-associated, metal-dependent; E=0.002 BS_yfnI; COG1368 Phosphoglycerol transferase and related proteins,; E=0.002 PFAM: PF00884; Sulfatase; E=7.8e-22.
      
 0.618
RB2663
Heparan N-sulfatase; PMID: 11181566 best DB hits: BLAST: gb:AAG41945.1; AF304053_1 (AF304053) heparan N-sulfatase [Mus; E=5e-36 gb:AAG41946.1; AF304054_1 (AF304054) mutant heparan N-sulfatase; E=2e-35 gb:AAF29467.1; (AF156255) N-sulfoglucosamine sulfohydrolase [Mus; E=1e-34 COG: Rv0296c; COG3119 Arylsulfatase A and related enzymes; E=2e-27 VC2041; COG3083 Predicted hydrolase of alkaline phosphatase; E=0.003 aslA; COG3119 Arylsulfatase A and related enzymes; E=0.005 PFAM: PF00884; Sulfatase; E=3.3e-16 PF01974; tRNA intron endonuclease, catal; E=0.44 PF00884; Sulfatase; E=8.6e-21.
      
 0.618
RB2732
Heparan N-sulfatase; PMID: 11181566 best DB hits: BLAST: gb:AAG41945.1; AF304053_1 (AF304053) heparan N-sulfatase [Mus; E=9e-29 gb:AAF29467.1; (AF156255) N-sulfoglucosamine sulfohydrolase [Mus; E=2e-28 gb:AAG41946.1; AF304054_1 (AF304054) mutant heparan N-sulfatase; E=3e-28 COG: Rv0296c; COG3119 Arylsulfatase A and related enzymes; E=9e-29 TM1703; COG1368 Phosphoglycerol transferase and related proteins,; E=2e-04 yejM; COG3083 Predicted hydrolase of alkaline phosphatase; E=0.001 PFAM: PF00884; Sulfatase; E=2.2e-23.
      
 0.618
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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