STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
acrAAcriflavine resistance protein A [Precursor]; PMID: 10984043 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=1e-54 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-52 pir:E83206; probable RND efflux membrane fusion protein precursor; E=2e-42 COG: PA2493; COG0845 Membrane-fusion protein; E=1e-55 PFAM: PF00364; Biotin-requiring enzyme; E=0.0006 PF00529; HlyD family secretion protein; E=4e-20; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (467 aa)    
Predicted Functional Partners:
acrB
Acriflavine resistance protein B; PMID: 8905231 PMID: 8407802 PMID: 7651136 best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:D83206; probable RND efflux transporter PA3522 [imported] -; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.957
mexF
Best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:T43024; ceoB protein - Burkholderia cepacia ----- gb:; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.818
mexB
Similar to multidrug resistance protein MexB; PMID: 7968531 PMID: 10187844 PMID: 10984043 best DB hits: BLAST: pir:H83071; RND multidrug efflux transporter MexD PA4598 [imported]; E=7e-91 embl:CAC14595.1; (AJ252200) putative RND protein; E=2e-85 swissprot:P52002; MEXB_PSEAE MULTIDRUG RESISTANCE PROTEIN MEXB; E=6e-85 COG: PA4598; COG0841 Cation/multidrug efflux pump; E=7e-92 PFAM: PF00873; AcrB/AcrD/AcrF family; E=7.9e-188; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.800
macB
ABC transporter, ATP-binding protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.759
ibeB
PMID: 10225861 best DB hits: BLAST: pir:A83347; probable outer membrane protein PA2391 [imported] -; E=1e-24 pir:F83329; probable outer membrane lipoprotein precursor PA2525; E=2e-23 gb:AAD05185.1; (AF110185) unknown [Burkholderia pseudomallei]; E=4e-23 COG: PA2391; COG1538 Outer membrane protein; E=1e-25 PFAM: PF02321; Outer membrane efflux protein; E=1.3e-18.
  
   0.696
acrD
Best DB hits: BLAST: pir:B83627; probable RND efflux transporter PA0158 [imported] -; E=9e-84 pir:F82829; acriflavin resistance protein XF0243 [imported] - Xylella; E=1e-81 pir:B82604; cation efflux system protein XF2083 [imported] - Xylella; E=6e-77 COG: PA0158; COG0841 Cation/multidrug efflux pump; E=8e-85 PFAM: PF00873; AcrB/AcrD/AcrF family; E=8.1e-17; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.673
ibeB-2
Probable outer membrane lipoprotein IbeB; PMID: 99242786 best DB hits: BLAST: gb:AAD30205.1; (AF094824) IbeB [Escherichia coli]; E=3e-33 swissprot:P77211; IBEB_ECOLI PROBABLE OUTER MEMBRANE LIPOPROTEIN; E=4e-33 gb:AAG54905.1; AE005237_1 (AE005237) putative resistance protein; E=1e-32 COG: ylcB; COG1538 Outer membrane protein; E=4e-34 PFAM: PF02321; Outer membrane efflux protein; E=1.3e-09.
  
   0.661
RB5117
Cation/multidrug efflux pump; PMID: 8407802 best DB hits: BLAST: pir:F82829; acriflavin resistance protein XF0243 [imported] - Xylella; E=2e-88 pir:F82159; transporter, AcrBD/F family VC1757 [imported] - Vibrio; E=3e-86 pir:B83627; probable RND efflux transporter PA0158 [imported] -; E=6e-79 COG: XF0243; COG0841 Cation/multidrug efflux pump; E=2e-89 PFAM: PF00873; AcrB/AcrD/AcrF family; E=3e-15; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.627
czcB
Cobalt-zinc-cadmium resistance protein; PMID: 2249654 PMID: 2184029 best DB hits: BLAST: gb:AAG09628.1; (AY007258) CztB [Pseudomonas fluorescens]; E=6e-17 pir:F83330; RND divalent metal cation efflux membrane fusion protein; E=2e-15 embl:CAB56470.1; (Y14018) czrB protein [Pseudomonas aeruginosa]; E=2e-14 COG: PA2521; COG0845 Membrane-fusion protein; E=1e-16 PFAM: PF00364; Biotin-requiring enzyme; E=4.2e-05 PF00529; HlyD family secretion protein; E=0.37; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
     0.624
czcA-2
Cation efflux system protein CZCA; PMID: 8829543 best DB hits: BLAST: swissprot:P94177; CZCA_ALCSP CATION EFFLUX SYSTEM PROTEIN CZCA; E=0.0 pir:A33830; cation efflux system membrane protein czcA - Alcaligenes; E=0.0 swissprot:P13511; CZCA_ALCEU COBALT-ZINC-CADMIUM RESISTANCE PROTEIN; E=0.0 COG: PA2520; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00804; Syntaxin; E=0.39 PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.512
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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