Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ibeBPMID: 10225861 best DB hits: BLAST: pir:A83347; probable outer membrane protein PA2391 [imported] -; E=1e-24 pir:F83329; probable outer membrane lipoprotein precursor PA2525; E=2e-23 gb:AAD05185.1; (AF110185) unknown [Burkholderia pseudomallei]; E=4e-23 COG: PA2391; COG1538 Outer membrane protein; E=1e-25 PFAM: PF02321; Outer membrane efflux protein; E=1.3e-18. (494 aa)    
Predicted Functional Partners:
RB11154
PMID: 10984043 best DB hits: BLAST: pir:A83330; probable RND efflux membrane fusion protein precursor; E=2e-06 gb:AAG57137.1; AE005434_1 (AE005434) putative membrane protein; E=2e-06 ddbj:BAA15928.1; (D90845) Membrane fusion protein MtrC precursor; E=4e-06 COG: PA2528; COG0845 Membrane-fusion protein; E=2e-07 PA3892; COG1566 Multidrug resistance efflux pump; E=1e-05 VC0628; COG0845 Membrane-fusion protein; E=4e-05 PFAM: PF00529; HlyD family secretion protein; E=4.2e-07; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.953
czcA
PMID: 2678100 best DB hits: BLAST: pir:H82300; probable multidrug resistance protein VC0629 [imported] -; E=3e-51 pir:S76433; cation efflux system protein czcA-2 - Synechocystis sp; E=4e-42 pir:G64595; acriflavine resistance protein - Helicobacter pylori; E=4e-41 COG: VC0629; COG0841 Cation/multidrug efflux pump; E=3e-52 PFAM: PF00873; AcrB/AcrD/AcrF family; E=1e-43; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.930
acrB
Acriflavine resistance protein B; PMID: 8905231 PMID: 8407802 PMID: 7651136 best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:D83206; probable RND efflux transporter PA3522 [imported] -; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
   0.792
mexF
Best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:T43024; ceoB protein - Burkholderia cepacia ----- gb:; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
   0.785
RB11156
Probable squalene-hopene cyclase; PMID: 1729216 PMID: 9532806 PMID: 2253626 PMID: 9295270 best DB hits: BLAST: pir:T35404; probable squalene-hopene cyclase - Streptomyces; E=1e-04 pir:A43300; squalene-hopene cyclase (EC 5.4.99.-) - Alicyclobacillus; E=0.008 gb:AAA75452.1; (M73834) squalene-hopene-cyclase [Alicyclobacillus; E=0.008 PFAM: PF01264; Chorismate synthase; E=0.74 PF00432; Prenyltransferase and squalen; E=0.00015.
       0.723
RB835
Probable multidrug resistance efflux pump; Best DB hits: BLAST: pir:A83330; probable RND efflux membrane fusion protein precursor; E=0.001 pir:A83342; conserved hypothetical protein PA2430 [imported] -; E=0.009 gb:AAC38085.1; (AF012101) VceA [Vibrio cholerae]; E=0.040 COG: PA2430; COG1566 Multidrug resistance efflux pump; E=9e-04 PFAM: PF00529; HlyD family secretion protein; E=3.1e-06.
  
   0.715
mexE
PMID: 8196548 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=9e-33 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-31 embl:CAC14594.1; (AJ252200) putative membrane fusion protein; E=1e-21 COG: PA2493; COG0845 Membrane-fusion protein; E=9e-34 PFAM: PF00364; Biotin-requiring enzyme; E=0.31 PF00529; HlyD family secretion protein; E=5.5e-13; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
   0.710
acrA
Acriflavine resistance protein A [Precursor]; PMID: 10984043 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=1e-54 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-52 pir:E83206; probable RND efflux membrane fusion protein precursor; E=2e-42 COG: PA2493; COG0845 Membrane-fusion protein; E=1e-55 PFAM: PF00364; Biotin-requiring enzyme; E=0.0006 PF00529; HlyD family secretion protein; E=4e-20; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
   0.696
mexB
Similar to multidrug resistance protein MexB; PMID: 7968531 PMID: 10187844 PMID: 10984043 best DB hits: BLAST: pir:H83071; RND multidrug efflux transporter MexD PA4598 [imported]; E=7e-91 embl:CAC14595.1; (AJ252200) putative RND protein; E=2e-85 swissprot:P52002; MEXB_PSEAE MULTIDRUG RESISTANCE PROTEIN MEXB; E=6e-85 COG: PA4598; COG0841 Cation/multidrug efflux pump; E=7e-92 PFAM: PF00873; AcrB/AcrD/AcrF family; E=7.9e-188; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
   0.646
RB5495
Conserved hypothetical protein-putative multidrug resistance efflux pump; Best DB hits: BLAST: pir:A83342; conserved hypothetical protein PA2430 [imported] -; E=4e-07 swissprot:P32716; YJCR_ECOLI HYPOTHETICAL 36.9 KDA PROTEIN IN; E=2e-05 gb:AAG59280.1; AE005641_5 (AE005641) putative membrane protein; E=2e-05 COG: PA2430; COG1566 Multidrug resistance efflux pump; E=4e-08 HIN0311; COG0845 Membrane-fusion protein; E=0.002 PFAM: PF00529; HlyD family secretion protein; E=0.00042.
  
   0.644
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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