Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hydHSensor kinase of the HydH/G two-component system; PMID: 2666400 PMID: 11243806 best DB hits: BLAST: gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=2e-23 gb:AAG09417.1; AF180147_9 (AF180147) bZIP histidine kinase TobS; E=5e-23 embl:CAB43735.1; (Y18245) bZIP histidine kinase [Pseudomonas; E=6e-23 COG: BH1920; COG0642 Sensory transduction histidine kinases; E=2e-22 PFAM: PF00072; Response regulator receiver doma; E=1.2e-21 PF00989; PAS domain; E=1e-08 PF00785; PAC motif; E=0.053. (488 aa)    
Predicted Functional Partners:
RB10924
Probable sensor/response regulator hybrid; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 
0.977
RB11986
Histidine protein kinase homolog GacS; PMID: 10762268 best DB hits: BLAST: gb:AAF04854.1; AF197912_1 (AF197912) histidine protein kinase; E=3e-57 pir:E83212; probable sensorresponse regulator hybrid PA3462; E=4e-56 pir:H83132; probable sensorresponse regulator hybrid PA4112; E=8e-51 COG: PA3462; COG0642 Sensory transduction histidine kinases; E=3e-57 PFAM: PF00989; PAS domain; E=3.5e-07 PF00512; His Kinase A (phosphoacceptor; E=2.5e-21 PF02518; Histidine kinase-, DNA gyrase; E=6.8e-39.
 
 
 0.974
RB4511
Sensory transduction histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
  
 
 0.974
RB641
Sensory histidine protein kinase; Best DB hits: BLAST: pir:G82753; two-component system, sensor protein XF0853 [imported] -; E=2e-41 gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=8e-39 pir:A82300; sensory box sensor histidine kinaseresponse regulator; E=4e-34 COG: XF0853; COG0642 Sensory transduction histidine kinases; E=2e-42 sll0779_1; COG2202 PAS/PAC domain; E=1e-23 VCA0736_1; COG0642 Sensory transduction histidine kinases; E=1e-23 PFAM: PF00785; PAC motif; E=8.5e-08 PF00989; PAS domain; E=0.013 PF00785; PAC motif; E=0.1.
 
 
0.974
RB10488
PMID: 20572072 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=3e-67 pir:E83443; probable sensorresponse regulator hybrid PA1611; E=2e-64 pir:H82211; sensory box sensor histidine kinaseresponse regulator; E=8e-61 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=7e-62 PFAM: PF00785; PAC motif; E=0.00076 PF00512; His Kinase A (phosphoacceptor) d; E=1.6e-28 PF02518; Histidine kinase-, DNA gyrase B-; E=1.6e-42.
 
 
 0.971
RB13175
PMID: 2201868 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=2e-67 pir:S75142; sensory transduction histidine kinase slr1759 -; E=2e-55 embl:CAA65047.1; (X95731) putative sensor kinase [Synechocystis; E=3e-55 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=1e-50 PFAM: PF00989; PAS domain; E=0.011 PF00785; PAC motif; E=0.075 PF00989; PAS domain; E=0.46.
 
 
0.961
RB8873
PMID: 7984107 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=2e-56 pir:S75525; sensory transduction histidine kinase sll1228 -; E=4e-50 pir:E82198; sensor histidine kinaseresponse regulator VC1445; E=5e-46 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=2e-43 PFAM: PF00785; PAC motif; E=0.00017 PF00512; His Kinase A (phosphoacceptor; E=1.1e-25 PF02518; Histidine kinase-, DNA gyrase; E=8.9e-44.
 
 
0.956
RB12326
Sensory histidine protein kinase; PMID: 11406410 best DB hits: BLAST: gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=2e-45 pir:F83153; probable two-component sensor PA3946 [imported] -; E=3e-36 pir:E83265; probable two-component sensor PA3044 [imported] -; E=2e-35 COG: PA3044; COG0642 Sensory transduction histidine kinases; E=2e-36 PFAM: PF01590; GAF domain; E=3.2e-20 PF00989; PAS domain; E=1.2e-07 PF00512; His Kinase A (phosphoacceptor) d; E=4.8e-16.
 
 
0.950
RB13112
PMID: 7984107 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=1e-69 pir:S75130; sensory transduction histidine kinase slr2098 -; E=4e-57 pir:C82424; sensor histidine kinase LuxQ VCA0736 [imported] - Vibrio; E=8e-56 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=8e-57 PFAM: PF00785; PAC motif; E=0.34 PF00512; His Kinase A (phosphoacceptor) d; E=8.1e-23 PF02518; Histidine kinase-, DNA gyrase B-; E=3.6e-41.
 
 
0.949
RB13181
PMID: 2201868 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=8e-57 pir:E82198; sensor histidine kinaseresponse regulator VC1445; E=4e-49 embl:CAA37397.1; (X53315) arcB [Escherichia coli]; E=3e-48 COG: sll1353_2; COG0642 Sensory transduction histidine kinases; E=7e-43 PFAM: PF00785; PAC motif; E=0.1 PF00989; PAS domain; E=8.8e-05 PF00785; PAC motif; E=9.8e-08.
 
 
0.948
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.