STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
merAMercuric reductase; PMID: 2536669 PMID: 2067577 best DB hits: BLAST: pir:S75167; mercuric reductase - Synechocystis sp. (strain PCC 6803); E=1e-121 embl:CAA70224.1; (Y09024) mercuric reductase [Bacillus cereus]; E=9e-60 pir:T44505; merA protein [imported] - Clostridium butyricum -----; E=3e-59 COG: slr1849; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-122 PFAM: PF00732; GMC oxidoreductases; E=0.074 PF02254; KTN NAD-binding domain; E=0.7 PF00899; ThiF family; E=0.22. (507 aa)    
Predicted Functional Partners:
aceF
PMID: 6345153 PMID: 6821375 PMID: 2121129 best DB hits: BLAST: pir:C82079; pyruvate dehydrogenase, E2 component, dihydrolipoamide; E=4e-55 pir:H75540; pyruvate dehydrogenase complex, dihydrolipoamide; E=4e-55 gb:AAK02978.1; (AE006128) AceF [Pasteurella multocida]; E=6e-54 COG: VC2413; COG0508 Dihydrolipoamide acyltransferases; E=3e-56 PFAM: PF00364; Biotin-requiring enzyme; E=2.1e-20 PF02817; e3 binding domain; E=8.5e-14 PF00198; 2-oxo acid dehydrogenases acylt; E=8.5e-100.
 0.872
RB11207
Conserved hypothetical protein; PMID: 8590279 best DB hits: BLAST: swissprot:Q55909; Y305_SYNY3 HYPOTHETICAL 22.2 KD PROTEIN SLR0305; E=2e-40 gb:AAB72174.1; (AF000657) unknown protein [Arabidopsis thaliana]; E=3e-33 gb:AAC72122.1; (AC005278) F15K9.14 [Arabidopsis thaliana]; E=1e-27 COG: slr0305; COG0398 Uncharacterized ACR; E=2e-41 aq_2066; COG1238 Uncharacterized membrane protein; E=7e-04 BS_yhjE; COG0398 Uncharacterized ACR; E=8e-04.
     0.870
sucB
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.864
kdgA
Alpha-ketoglutarate dehydrogenase E1; PMID: 2404759 PMID: 2404760 best DB hits: BLAST: gb:AAC23516.1; (AF068740) alpha-ketoglutarate dehydrogenase; E1; E=0.0 swissprot:P20707; ODO1_AZOVI 2-OXOGLUTARATE DEHYDROGENASE E1; E=0.0 pir:G83448; 2-oxoglutarate dehydrogenase (E1 subunit) PA1585; E=0.0 COG: PA1585; COG0567 Pyruvate and 2-oxoglutarate dehydrogenases, E1; E=0.0 BH0776; COG1071 Thiamine pyrophosphate-dependent dehydrogenases, E1; E=3e-05 VNG2218G; COG0022 Thiamine pyrophosphate-dependent dehydrogenases,; E=0.008 PFAM: PF00676; Dehydrogenase E1 component; E=3.8e-40.
  
 0.754
rcp1
Response regulator rcp1; PMID: 7699720 PMID: 9278513 best DB hits: BLAST: embl:CAB62661.1; (AL133422) hypothetical protein SCM1.03c; E=8e-33 pir:D75276; response regulator - Deinococcus radiodurans (strain R1); E=1e-31 swissprot:Q55169; RCP1_SYNY3 RESPONSE REGULATOR RCP1 -----; E=1e-25 COG: DR2420; COG0784 CheY-like receiver domains; E=1e-32 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-09 sll0039; COG0784 CheY-like receiver domains; E=6e-09 PFAM: PF00072; Response regulator receiver doma; E=6.5e-19.
       0.741
cph1
Light-regulated histidine kinase 1; PMID: 10567266 best DB hits: BLAST: pir:C75276; sensory box sensor histidine kinase - Deinococcus; E=8e-45 swissprot:Q55168; PHY1_SYNY3 PHYTOCHROME-LIKE PROTEIN CPH1; E=1e-41 embl:CAB62662.1; (AL133422) putative two-component sensor; E=2e-41 COG: DR2419_2; COG0642 Sensory transduction histidine kinases; E=8e-46 PFAM: PF00512; His Kinase A (phosphoacceptor) doma; E=1e-12 PF02518; Histidine kinase-, DNA gyrase B-, p; E=3.5e-35.
       0.741
RB11204
Hypothetical protein.
       0.741
RB11258
Best DB hits: BLAST: pir:C82165; conserved hypothetical protein VC1723 [imported] -; E=6e-12 swissprot:P71772; YE91_MYCTU HYPOTHETICAL 26.6 KDA PROTEIN RV1491C; E=8e-07 pir:B71448; hypothetical protein - Arabidopsis thaliana -----; E=1e-04 COG: VC1723; COG0398 Uncharacterized ACR; E=5e-13.
 
     0.684
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.646
arsR-2
Probable ArsR-family transcriptional regulator; PMID: 8843436 best DB hits: BLAST: embl:CAB71255.1; (AL138598) putative ArsR-family transcriptional; E=2e-06 pir:S74901; arsenical resistance operon repressor - Synechocystis; E=9e-05 pir:D64465; hypothetical protein MJ1325 - Methanococcus jannaschii; E=1e-04 COG: sll1957; COG0640 Predicted transcriptional regulators; E=9e-06 PFAM: PF01022; Bacterial regulatory protein, arsR f; E=9.4e-13.
     
 0.615
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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