Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
czcBCobalt-zinc-cadmium resistance protein; PMID: 2249654 PMID: 2184029 best DB hits: BLAST: gb:AAG09628.1; (AY007258) CztB [Pseudomonas fluorescens]; E=6e-17 pir:F83330; RND divalent metal cation efflux membrane fusion protein; E=2e-15 embl:CAB56470.1; (Y14018) czrB protein [Pseudomonas aeruginosa]; E=2e-14 COG: PA2521; COG0845 Membrane-fusion protein; E=1e-16 PFAM: PF00364; Biotin-requiring enzyme; E=4.2e-05 PF00529; HlyD family secretion protein; E=0.37; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (407 aa)    
Predicted Functional Partners:
czcA-2
Cation efflux system protein CZCA; PMID: 8829543 best DB hits: BLAST: swissprot:P94177; CZCA_ALCSP CATION EFFLUX SYSTEM PROTEIN CZCA; E=0.0 pir:A33830; cation efflux system membrane protein czcA - Alcaligenes; E=0.0 swissprot:P13511; CZCA_ALCEU COBALT-ZINC-CADMIUM RESISTANCE PROTEIN; E=0.0 COG: PA2520; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00804; Syntaxin; E=0.39 PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.959
czcA-3
Cation efflux system protein czcA-1; PMID: 8829543 PMID: 2678100 best DB hits: BLAST: gb:AAG54908.1; AE005237_4 (AE005237) putative inner membrane; E=1e-109 swissprot:P38054; YBDE_ECOLI HYPOTHETICAL 114.7 KDA PROTEIN IN; E=1e-109 gb:AAD11749.1; (AF067954) putative inner membrane protoncation; E=1e-109 COG: ybdE; COG0841 Cation/multidrug efflux pump; E=1e-110 PFAM: PF00873; AcrB/AcrD/AcrF family; E=5.1e-154; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   0.804
macB
ABC transporter, ATP-binding protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.658
RB4870
PMID: 10988064 best DB hits: BLAST: gb:AAG10499.1; AF279106_61 (AF279106) predicted cation efflux system; E=5e-95 pir:A83186; probable RND efflux transporter PA3676 [imported] -; E=2e-75 pir:F82829; acriflavin resistance protein XF0243 [imported] - Xylella; E=1e-71 COG: PA3676; COG0841 Cation/multidrug efflux pump; E=2e-76 PFAM: PF00873; AcrB/AcrD/AcrF family; E=6.1e-05; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.651
acrD
Best DB hits: BLAST: pir:B83627; probable RND efflux transporter PA0158 [imported] -; E=9e-84 pir:F82829; acriflavin resistance protein XF0243 [imported] - Xylella; E=1e-81 pir:B82604; cation efflux system protein XF2083 [imported] - Xylella; E=6e-77 COG: PA0158; COG0841 Cation/multidrug efflux pump; E=8e-85 PFAM: PF00873; AcrB/AcrD/AcrF family; E=8.1e-17; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.643
acrB
Acriflavine resistance protein B; PMID: 8905231 PMID: 8407802 PMID: 7651136 best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:D83206; probable RND efflux transporter PA3522 [imported] -; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.631
RB5117
Cation/multidrug efflux pump; PMID: 8407802 best DB hits: BLAST: pir:F82829; acriflavin resistance protein XF0243 [imported] - Xylella; E=2e-88 pir:F82159; transporter, AcrBD/F family VC1757 [imported] - Vibrio; E=3e-86 pir:B83627; probable RND efflux transporter PA0158 [imported] -; E=6e-79 COG: XF0243; COG0841 Cation/multidrug efflux pump; E=2e-89 PFAM: PF00873; AcrB/AcrD/AcrF family; E=3e-15; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.627
acrA
Acriflavine resistance protein A [Precursor]; PMID: 10984043 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=1e-54 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-52 pir:E83206; probable RND efflux membrane fusion protein precursor; E=2e-42 COG: PA2493; COG0845 Membrane-fusion protein; E=1e-55 PFAM: PF00364; Biotin-requiring enzyme; E=0.0006 PF00529; HlyD family secretion protein; E=4e-20; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
     0.624
czcC
Probable divalent cation resistant determinant protein C; PMID: 8829543 best DB hits: BLAST: gb:AAG09627.1; (AY007258) CztC [Pseudomonas fluorescens]; E=3e-15 pir:JC4698; divalent cation resistant determinant protein C -; E=4e-15 swissprot:P13509; CZCC_ALCEU COBALT-ZINC-CADMIUM RESISTANCE; E=3e-14 COG: PA2522; COG1538 Outer membrane protein; E=8e-13 PFAM: PF02321; Outer membrane efflux protein; E=2.9e-11.
  
   0.613
RB191
Cation efflux system, AcrB/AcrD/AcrF family; PMID: 8407802 best DB hits: BLAST: pir:S76433; cation efflux system protein czcA-2 - Synechocystis sp; E=2e-86 ddbj:BAB07535.1; (AP001520) cation efflux system [Bacillus; E=1e-82 pir:F82263; probable multidrug resistance protein VC0914 [imported] -; E=1e-76 COG: sll0142; COG0841 Cation/multidrug efflux pump; E=1e-87 PFAM: PF00873; AcrB/AcrD/AcrF family; E=4.7e-88; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
   0.591
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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