STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
czcA-2Cation efflux system protein CZCA; PMID: 8829543 best DB hits: BLAST: swissprot:P94177; CZCA_ALCSP CATION EFFLUX SYSTEM PROTEIN CZCA; E=0.0 pir:A33830; cation efflux system membrane protein czcA - Alcaligenes; E=0.0 swissprot:P13511; CZCA_ALCEU COBALT-ZINC-CADMIUM RESISTANCE PROTEIN; E=0.0 COG: PA2520; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00804; Syntaxin; E=0.39 PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1053 aa)    
Predicted Functional Partners:
czcB
Cobalt-zinc-cadmium resistance protein; PMID: 2249654 PMID: 2184029 best DB hits: BLAST: gb:AAG09628.1; (AY007258) CztB [Pseudomonas fluorescens]; E=6e-17 pir:F83330; RND divalent metal cation efflux membrane fusion protein; E=2e-15 embl:CAB56470.1; (Y14018) czrB protein [Pseudomonas aeruginosa]; E=2e-14 COG: PA2521; COG0845 Membrane-fusion protein; E=1e-16 PFAM: PF00364; Biotin-requiring enzyme; E=4.2e-05 PF00529; HlyD family secretion protein; E=0.37; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.959
czcC
Probable divalent cation resistant determinant protein C; PMID: 8829543 best DB hits: BLAST: gb:AAG09627.1; (AY007258) CztC [Pseudomonas fluorescens]; E=3e-15 pir:JC4698; divalent cation resistant determinant protein C -; E=4e-15 swissprot:P13509; CZCC_ALCEU COBALT-ZINC-CADMIUM RESISTANCE; E=3e-14 COG: PA2522; COG1538 Outer membrane protein; E=8e-13 PFAM: PF02321; Outer membrane efflux protein; E=2.9e-11.
 
  
 0.756
RB334
Copper-transporting ATPase; PMID: 8490659 best DB hits: BLAST: gb:AAD11750.1; (AF067954) putative cation transporting P-type; E=0.0 swissprot:Q9X5V3; ATCU_RHILV COPPER-TRANSPORTING ATPASE -----; E=0.0 embl:CAC07984.1; (AJ278983) CopF Cu-ATPase [Ralstonia; E=1e-180 COG: sll1920; COG2217 Cation transport ATPases; E=1e-150 PFAM: PF00122; E1-E2 ATPase; E=1.8e-93 PF00702; haloacid dehalogenase-like hyd; E=1.8e-32.
   
 0.708
RB188
Probable membrane-fusion protein; Best DB hits: BLAST: pir:T31342; ragD protein - Bradyrhizobium japonicum ----- embl:; E=2e-20 pir:A83330; probable RND efflux membrane fusion protein precursor; E=2e-12 pir:D83099; probable RND efflux membrane fusion protein precursor; E=2e-12 COG: PA2528; COG0845 Membrane-fusion protein; E=2e-13 PFAM: PF00364; Biotin-requiring enzyme; E=0.18 PF00529; HlyD family secretion protein; E=0.05; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.570
sigE
Probable extracytoplasmic function alternative sigma factor; PMID: 3052291 PMID: 8052622 best DB hits: BLAST: embl:CAC01348.1; (AL390975) putative ECF-subfamily sigma factor; E=9e-08 gb:AAC45221.1; (U87307) extracytoplasmic function alternative; E=1e-04 embl:CAC17654.1; (AL450450) putative ECF sigma factor; E=1e-04 COG: Rv1221; COG1595 DNA-directed RNA polymerase specialized sigma; E=6e-05 PFAM: PF00776; Sigma-70 factor (ECF subfamily); E=3.3e-10.
       0.566
RB11244
Serine/threonine protein kinase; PMID: 1956325 PMID: 1835513 PMID: 3291115 best DB hits: BLAST: ddbj:BAB06223.1; (AP001515) serinethreonine protein kinase; E=1e-44 pir:T36501; probable serinethreonine protein kinase - Streptomyces; E=7e-43 pir:T36717; probable serinethreonine protein kinase - Streptomyces; E=3e-42 COG: BH2504_1; COG0515 Serine/threonine protein kinases; E=1e-45 PFAM: PF00069; Protein kinase domain; E=2.2e-50.
       0.566
mexA
Multidrug resistance protein MexA; PMID: 7968531 best DB hits: BLAST: gb:AAD12178.1; (AF029405) periplasmic linker protein [Pseudomonas; E=8e-20 swissprot:P37636; YHIU_ECOLI HYPOTHETICAL 41.2 KD LIPOPROTEIN IN; E=3e-19 gb:AAG58654.1; AE005576_13 (AE005576) putative membrane protein; E=4e-19 COG: yhiU; COG0845 Membrane-fusion protein; E=3e-20 PFAM: PF00364; Biotin-requiring enzyme; E=0.0015 PF00529; HlyD family secretion protein; E=3.1e-06; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.532
mexE
PMID: 8196548 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=9e-33 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-31 embl:CAC14594.1; (AJ252200) putative membrane fusion protein; E=1e-21 COG: PA2493; COG0845 Membrane-fusion protein; E=9e-34 PFAM: PF00364; Biotin-requiring enzyme; E=0.31 PF00529; HlyD family secretion protein; E=5.5e-13; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.524
acrA
Acriflavine resistance protein A [Precursor]; PMID: 10984043 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=1e-54 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-52 pir:E83206; probable RND efflux membrane fusion protein precursor; E=2e-42 COG: PA2493; COG0845 Membrane-fusion protein; E=1e-55 PFAM: PF00364; Biotin-requiring enzyme; E=0.0006 PF00529; HlyD family secretion protein; E=4e-20; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   0.512
RB11236
Hypothetical protein.
       0.486
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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