Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sigEProbable extracytoplasmic function alternative sigma factor; PMID: 3052291 PMID: 8052622 best DB hits: BLAST: embl:CAC01348.1; (AL390975) putative ECF-subfamily sigma factor; E=9e-08 gb:AAC45221.1; (U87307) extracytoplasmic function alternative; E=1e-04 embl:CAC17654.1; (AL450450) putative ECF sigma factor; E=1e-04 COG: Rv1221; COG1595 DNA-directed RNA polymerase specialized sigma; E=6e-05 PFAM: PF00776; Sigma-70 factor (ECF subfamily); E=3.3e-10. (201 aa)    
Predicted Functional Partners:
RB11244
Serine/threonine protein kinase; PMID: 1956325 PMID: 1835513 PMID: 3291115 best DB hits: BLAST: ddbj:BAB06223.1; (AP001515) serinethreonine protein kinase; E=1e-44 pir:T36501; probable serinethreonine protein kinase - Streptomyces; E=7e-43 pir:T36717; probable serinethreonine protein kinase - Streptomyces; E=3e-42 COG: BH2504_1; COG0515 Serine/threonine protein kinases; E=1e-45 PFAM: PF00069; Protein kinase domain; E=2.2e-50.
   
   0.777
czcB
Cobalt-zinc-cadmium resistance protein; PMID: 2249654 PMID: 2184029 best DB hits: BLAST: gb:AAG09628.1; (AY007258) CztB [Pseudomonas fluorescens]; E=6e-17 pir:F83330; RND divalent metal cation efflux membrane fusion protein; E=2e-15 embl:CAB56470.1; (Y14018) czrB protein [Pseudomonas aeruginosa]; E=2e-14 COG: PA2521; COG0845 Membrane-fusion protein; E=1e-16 PFAM: PF00364; Biotin-requiring enzyme; E=4.2e-05 PF00529; HlyD family secretion protein; E=0.37; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
       0.566
czcA-2
Cation efflux system protein CZCA; PMID: 8829543 best DB hits: BLAST: swissprot:P94177; CZCA_ALCSP CATION EFFLUX SYSTEM PROTEIN CZCA; E=0.0 pir:A33830; cation efflux system membrane protein czcA - Alcaligenes; E=0.0 swissprot:P13511; CZCA_ALCEU COBALT-ZINC-CADMIUM RESISTANCE PROTEIN; E=0.0 COG: PA2520; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00804; Syntaxin; E=0.39 PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
       0.566
RB1467
Hypothetical protein-transmembrane region and signal peptide prediction; Best DB hits: BLAST: gb:AAF87662.1; AF223645_1 (AF223645) lipase [uncultured bacterium]; E=0.54 PFAM: PF01738; Dienelactone hydrolase family; E=0.00062.
  
     0.467
RB11670
PMID: 2974033 best DB hits: BLAST: pir:A75265; ferric enterobactin esterase-related protein -; E=0.002 COG: DR2506; COG2382 Enterochelin esterase and related enzymes; E=2e-04.
  
    0.437
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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