Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cypXProbable cytochrome P450 T9E850; PMID: 20411542 best DB hits: BLAST: pir:T06288; probable cytochrome P450 T9E8.50 - Arabidopsis thaliana; E=5e-14 ddbj:BAA31438.1; (AB010393) ALK6 [Yarrowia lipolytica]; E=3e-13 pir:C81286; probable cytochrome P450 Cj1411c [imported] -; E=5e-13 COG: Cj1411c; COG2124 Cytochrome P450; E=4e-14 PFAM: PF00067; Cytochrome P450; E=1e-20. (514 aa)    
Predicted Functional Partners:
RB6500
Mycocerosate synthase; PMID: 3880746 best DB hits: BLAST: pir:S72705; mycocerosate synthase (EC 2.3.1.111) - Mycobacterium; E=0.0 pir:H70819; probable polyketide synthase - Mycobacterium tuberculosis; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=1e-180 COG: PA2402_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=4e-99 BS_ppsD_3; COG1020 Non-ribosomal peptide synthetase modules and; E=4e-92 PA2424_2; COG1020 Non-ribosomal peptide synthetase modules and related; E=1e-91 PFAM: PF00108; Thiolase, N-terminal domain; E=2.7e-06 PF00109; Beta-keto [...]
 
 
 0.982
RB11975
Polyketide synthase; PMID: 10662695 PMID: 10649995 best DB hits: BLAST: gb:AAF26921.1; AF210843_18 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF26923.1; AF210843_20 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=0.0 COG: BS_fabD; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=7e-31 PA2965; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase I; E=3e-28 PA5234; COG0604 NADPH:quinone reductase and related Zn-dependent; E=2e-27 PFAM: PF00108; Thiolase, N-terminal domain; E=7.3e-07 PF00109; Beta-ketoacyl s [...]
 
 0.971
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
    
 0.905
RB386
Saframycin Mx1 synthetase B; PMID: 8936303 best DB hits: BLAST: pir:T18551; saframycin Mx1 synthetase B - Myxococcus xanthus -----; E=1e-112 pir:T34918; polyketide synthase - Streptomyces coelicolor -----; E=1e-102 pir:H83343; probable non-ribosomal peptide synthetase PA2424; E=1e-101 COG: PA2424_1; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid; E=1e-102 Rv1529; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases; E=7e-83 Ta1189; COG0156 7-keto-8-aminopelargonate synthetase and related; E=6e-62 PFAM: PF00501; AMP-binding enzyme; E=2.2e-08 PF00550; Phosphopantetheine attac [...]
 
 0.891
RB2103
Acyl-CoA synthetase; PMID: 9634230 best DB hits: BLAST: pir:T18551; saframycin Mx1 synthetase B - Myxococcus xanthus -----; E=1e-101 pir:H83343; probable non-ribosomal peptide synthetase PA2424; E=4e-96 gb:AAG02359.1; AF210249_18 (AF210249) peptide synthetase NRPS5-4-3; E=7e-93 COG: PA2424_1; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid; E=4e-97 Rv3826; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases; E=7e-82 VNG1339C; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid; E=9e-19 PFAM: PF00501; AMP-binding enzyme; E=1.7e-07 PF00550; Phosphopantetheine attachment sit; [...]
 
 0.875
RB10996
Best DB hits: BLAST: gb:AAD39269.1; AC007203_1 (AC007203) Putative UDP-glucose:sterol; E=9e-62 embl:CAB06082.1; (Z83833) UDP-glucose:sterol glucosyltransferase; E=9e-59 gb:AAF27006.1; AC016827_17 (AC016827) UDP-glucose:sterol; E=9e-59 COG: YLR189c_2; COG1819 Glycosyl transferases, related to; E=4e-51.
 
 
 0.867
RB7276
Peptide synthetase; PMID: 20392447 best DB hits: BLAST: embl:CAC01604.1; (AJ269505) peptide synthetase [Anabaena sp. 90]; E=4e-91 embl:CAC11137.1; (AJ250581) NikP1 protein [Streptomyces tendae]; E=9e-91 gb:AAF17281.1; (AF204805) NosD [Nostoc sp. GSV224]; E=4e-89 COG: PA2424_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=9e-85 BS_ppsC_1; COG1020 Non-ribosomal peptide synthetase modules and; E=5e-83 BS_dhbF; COG1020 Non-ribosomal peptide synthetase modules and related; E=2e-81 PFAM: PF00501; AMP-binding enzyme; E=2.2e-131 PF00550; Phosphopantetheine attachment; E=3.1e [...]
 
 
 0.814
RB13025
Probable monooxygenase; PMID: 1444267 best DB hits: BLAST: pir:D83229; probable FAD-dependent monooxygenase PA3328 [imported] -; E=1e-07 pir:H70986; probable hyroxylase - Mycobacterium tuberculosis (strain; E=2e-07 pir:T35323; probable hydroxylase - Streptomyces coelicolor -----; E=1e-06 COG: PA3328; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related; E=1e-08 BS_yetM; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and; E=2e-04 PA2587; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related; E=5e-04 PFAM: PF01360; Monooxygenase; E=2.8e-12.
 
 
 0.685
aas
Acyl-[ACP]--phospholipid O-acyltransferase; PMID: 8300626 best DB hits: BLAST: pir:A81368; probable 2-acylglycerophosphoethanolamine acyltransferase; E=2e-89 swissprot:P31119; AAS_ECOLI AAS BIFUNCTIONAL PROTEIN [INCLUDES:; E=5e-59 gb:AAG57948.1; AE005512_7 (AE005512); E=6e-59 COG: Cj0938c_3; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid; E=6e-66 aas_2; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases; E=6e-50 VNG1339C; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid; E=2e-28 PFAM: PF01553; Acyltransferase; E=7.6e-22 PF00501; AMP-binding enzyme; E=2.4e-07.
  
 0.683
RB13026
Probable monooxygenase; PMID: 1444267 best DB hits: BLAST: pir:T37167; probable oxidoreductase - Streptomyces coelicolor; E=4e-08 gb:AAD25066.1; AF121000_13 (AF121000) oxidoreductase protein; E=0.001 pir:D83122; probable FAD-dependent monooxygenase PA4190 [imported] -; E=0.004 COG: PA4190; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related; E=4e-04 PFAM: PF01360; Monooxygenase; E=0.33.
 
 
 0.679
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.