STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hsdS-3Probable Type I restriction enzyme EcoBI specificity protein; PMID: 6304321 best DB hits: BLAST: embl:CAA10700.1; (AJ132566) HsdS protein [Escherichia coli]; E=5e-13 swissprot:P06990; T1SB_ECOLI TYPE I RESTRICTION ENZYME ECOBI; E=2e-10 gb:AAG18734.1; (AE004978) type I restriction modification enzyme,; E=4e-09 COG: VNG0107G; COG0732 Restriction endonuclease S subunits; E=4e-10 PFAM: PF01420; Type I restriction modification D; E=3.3e-06. (385 aa)    
Predicted Functional Partners:
hsdM-2
PMID: 8412658 best DB hits: BLAST: swissprot:Q47282; T1ME_ECOLI TYPE I RESTRICTION ENZYME ECOEI M; E=4e-13 gb:AAG59530.1; AE005666_2 (AE005666) putative restriction; E=1e-12 pir:A47200; EcoA system protein M - Escherichia coli ----- gb:; E=2e-12 COG: Rv2756c; COG0286 Type I restriction-modification system; E=4e-10 PFAM: PF02506; Type I restriction modification s; E=3.3e-06.
 
 
 0.956
RB11618
Type I restriction enzyme M protein; PMID: 8412658 PMID: 9440532 best DB hits: BLAST: gb:AAG59530.1; AE005666_2 (AE005666) putative restriction; E=2e-32 swissprot:Q47282; T1ME_ECOLI TYPE I RESTRICTION ENZYME ECOEI M; E=2e-32 pir:A47200; EcoA system protein M - Escherichia coli ----- gb:; E=1e-31 COG: hsdM; COG0286 Type I restriction-modification system; E=3e-19 PFAM: PF02506; Type I restriction modification s; E=6.9e-10 PF02384; N-6 DNA Methylase; E=3.2e-16.
 
 
 0.917
RB11642
Type I restriction enzym, M protein; PMID: 8412658 best DB hits: BLAST: gb:AAG59530.1; AE005666_2 (AE005666) putative restriction; E=1e-32 swissprot:Q47282; T1ME_ECOLI TYPE I RESTRICTION ENZYME ECOEI M; E=5e-32 pir:A47200; EcoA system protein M - Escherichia coli ----- gb:; E=5e-32 COG: hsdM; COG0286 Type I restriction-modification system; E=1e-19 PFAM: PF02506; Type I restriction modification s; E=7e-11 PF02384; N-6 DNA Methylase; E=1.9e-15.
 
 
 0.917
hsdR-3
PMID: 8412658 best DB hits: BLAST: swissprot:Q07736; T1RA_ECOLI TYPE I RESTRICTION ENZYME ECOAI R; E=3e-33 gb:AAG59531.1; AE005666_3 (AE005666) putative restriction; E=3e-33 swissprot:P08956; T1RK_ECOLI TYPE I RESTRICTION ENZYME ECOKI R; E=4e-29 COG: hsdR; COG0610 Restriction enzymes type I helicase subunits and; E=4e-30 YDR332w; COG1061 DNA or RNA helicases of superfamily II; E=2e-09 MJECL40; COG0610 Restriction enzymes type I helicase subunits and; E=0.001 PFAM: PF00270; DEAD/DEAH box helicase; E=0.14 PF00271; Helicase conserved C-terminal doma; E=0.6.
 
 
 0.915
RB11415
Conserved hypothetical protein; PMID: 4515613 PMID: 354508 PMID: 6221115 best DB hits: BLAST: gb:AAA96561.1; (J02459) ea59 (525) [bacteriophage lambda]; E=5e-05 pir:S49559; phage Hau3 resistance protein - Streptomyces lividans; E=2e-04 gb:AAK02366.1; (AE006063) unknown [Pasteurella multocida]; E=0.014 PFAM: PF02463; SMC domain N terminal domain; E=0.039.
 
     0.914
RB11408
Hypothetical protein.
 
 
 0.901
RB11622
Type I restriction enzyme, R protein; PMID: 8412658 best DB hits: BLAST: gb:AAG59531.1; AE005666_3 (AE005666) putative restriction; E=5e-31 swissprot:Q07736; T1RA_ECOLI TYPE I RESTRICTION ENZYME ECOAI R; E=6e-31 swissprot:P08956; T1RK_ECOLI TYPE I RESTRICTION ENZYME ECOKI R; E=1e-30 COG: hsdR; COG0610 Restriction enzymes type I helicase subunits and; E=1e-31 VC0812_2; COG1061 DNA or RNA helicases of superfamily II; E=9e-13 MJECL40; COG0610 Restriction enzymes type I helicase subunits and; E=3e-05 PFAM: PF00270; DEAD/DEAH box helicase; E=1.5e-06 PF00271; Helicase conserved C-terminal do [...]
 
 
 0.839
RB11416
Conserved hypothetical protein; PMID: 12003951 best DB hits: BLAST: gb:AAK02367.1; (AE006063) unknown [Pasteurella multocida]; E=0.049 gb:AAA96560.1; (J02459) ea31 (296) [bacteriophage lambda]; E=0.19.
  
    0.780
hsdR-2
HsdR; Subunit R is required for both nuclease and ATPase activities, but not for modification.
  
  
 0.705
hsdM
Type I restriction enzyme StySPI M protein; PMID: 1409708 PMID: 3025838 best DB hits: BLAST: swissprot:P07989; T1M_SALPO TYPE I RESTRICTION ENZYME STYSPI M; E=1e-135 gb:AAA23985.1; (L02508) restriction-modification enzyme type I M; E=1e-134 swissprot:P08957; T1MK_ECOLI TYPE I RESTRICTION ENZYME ECOKI M; E=1e-134 COG: hsdM; COG0286 Type I restriction-modification system; E=1e-135 PFAM: PF02506; Type I restriction modification s; E=0.00016 PF02384; N-6 DNA Methylase; E=7.2e-40.
  
 
 0.650
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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