STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mqnDConserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (302 aa)    
Predicted Functional Partners:
mqnC
Conserved hypothetical protein-putative oxidoreductase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
  
 0.981
mqnA
Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
   
 0.859
mqnE
Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.
 
   
 0.819
RB1081
Conserved hypothetical protein-putative nucleoside phosphorylase; PMID: 8843436 best DB hits: BLAST: embl:CAB93401.1; (AL357524) hypothetical protein SCD12A.10c; E=2e-04 ddbj:BAB06409.1; (AP001516) BH2690~unknown [Bacillus halodurans]; E=0.002 pir:T09897; hypothetical protein T22A6.170 - Arabidopsis thaliana; E=0.038 COG: BH2690; COG0775 Nucleoside phosphorylase; E=2e-04.
 
   
 0.806
ubiA
PMID: 1644192 best DB hits: BLAST: gb:AAB41844.1; (U61168) 4-hydroxybenzoate octaprenyltransferase; E=3e-34 ddbj:BAB05369.1; (AP001512) 4-hydroxybenzoate; E=4e-34 pir:E70304; 4-hydroxybenzoate octaprenyltransferase - Aquifex; E=2e-31 COG: BH1650; COG0382 4-hydroxybenzoate polyprenyltranferase; E=4e-35 AF2036; COG0109 Polyprenyltransferase (cytochrome oxidase assembly; E=0.006 PFAM: PF01040; UbiA prenyltransferase family; E=2e-37.
 
   
 0.804
RB223
4-hydroxybenzoate decarboxylase; PMID: 10438791 best DB hits: BLAST: ddbj:BAB07649.1; (AP001520) BH3930~unknown conserved protein in; E=1e-170 swissprot:Q9Z8L0; Y328_CHLPN HYPOTHETICAL PROTEIN; E=1e-86 swissprot:O84087; Y085_CHLTR HYPOTHETICAL PROTEIN CT085 -----; E=3e-86 COG: BH3930; COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and; E=1e-171 PFAM: PF01977; Protein of unknown function UPF0096; E=6.7e-19; Belongs to the UbiD family.
  
   
 0.797
ubiX
3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.
 
   
 0.735
trzA
Probable chlorohydrolase; PMID: 7592318 best DB hits: BLAST: ddbj:BAB05411.1; (AP001512) BH1692~unknown conserved protein in; E=1e-18 swissprot:Q9RW45; Y824_DEIRA HYPOTHETICAL PROTEIN DR0824 -----; E=1e-16 swissprot:O27549; YF05_METTH HYPOTHETICAL PROTEIN MTH1505 -----; E=5e-16 COG: BH1692; COG0402 Cytosine deaminase and related metal-dependent; E=1e-19 PFAM: PF00744; Dihydroorotase-like; E=0.025 PF01979; Adenine deaminase; E=0.099 PF00962; Adenosine/AMP deaminase; E=0.05.
  
     0.666
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
       0.559
RB11955
Probable serine/threonine-protein kinase pknB; PMID: 11410353 PMID: 11856348 PMID: 8969512 PMID: 11234002 best DB hits: BLAST: pir:H69878; probable protein kinase (EC 2.7.1.-) yloP - Bacillus; E=1e-44 swissprot:P54744; PKNB_MYCLE PUTATIVE SERINETHREONINE-PROTEIN; E=9e-44 swissprot:P71584; PKNB_MYCTU PUTATIVE SERINETHREONINE-PROTEIN; E=1e-42 COG: BS_yloP_1; COG0515 Serine/threonine protein kinases; E=1e-45 PFAM: PF00069; Protein kinase domain; E=9.2e-49.
       0.536
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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