Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RB11969Conserved hypothetical protein; PMID: 9389475 best DB hits: BLAST: pir:D69211; conserved hypothetical protein MTH835 - Methanobacterium; E=4e-09 pir:G64401; hypothetical protein MJ0815 - Methanococcus jannaschii; E=7e-06 gb:AAB90178.1; (AE001029) conserved hypothetical protein; E=5e-05 COG: MTH835; COG1821 Predicted ATP-utilizing enzymes of ATP-grasp; E=4e-10 PFAM: PF02655; Domain of unknown function DU; E=5.6e-08. (381 aa)    
Predicted Functional Partners:
RB6209
Conserved hypothetical protein; PMID: 8688087 best DB hits: BLAST: swissprot:Q58250; Y840_METJA HYPOTHETICAL PROTEIN MJ0840 -----; E=3e-29 pir:C69211; conserved hypothetical protein MTH834 - Methanobacterium; E=1e-24 gb:AAB90759.1; (AE001071) conserved hypothetical protein; E=8e-24 COG: MJ0840; COG1548 Predicted nucleotide-binding enzyme; E=2e-30 PFAM: PF00370; FGGY family of carbohydrate kinases,; E=0.78 PF01897; Protein of unknown function DUF66; E=8.5e-35.
 
  
 0.980
RB6292
Conserved hypothetical protein; PMID: 8688087 best DB hits: BLAST: swissprot:Q58114; Y703_METJA HYPOTHETICAL PROTEIN MJ0703 -----; E=9e-14 gb:AAG32955.1; (AF032114) unknown [Methylobacterium extorquens]; E=6e-07 pir:A69189; phosphoribosylformimino-5-aminoimidazole carboxamide; E=4e-05 COG: MJ0703; COG1411 Archaeal family of HisA paralogs; E=9e-15; Belongs to the HisA/HisF family.
 
     0.801
fwdA
Putative formylmethanofuran dehydrogenase subunit A; PMID: 9651254 PMID: 10215859 PMID: 10848995 PMID: 11073907 best DB hits: BLAST: gb:AAG32950.1; (AF032114) putative formylmethanofuran; E=6e-98 pir:S57456; formylmethanofuran dehydrogenase (EC 1.2.99.5); E=8e-72 pir:G69074; formylmethanofuran dehydrogenase (EC 1.2.99.5); E=3e-71 COG: MTH1557; COG1229 Formylmethanofuran dehydrogenase subunit A; E=3e-72 PFAM: PF02612; N-acetylglucosamine-6-phosphat; E=0.0077.
 
   
 0.788
ffsA
Formylmethanofuran--tetrahydromethanopterin N-formyltransferase ffsA; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family.
 
     0.787
RB5685
Conserved hypothetical protein; PMID: 9389475 best DB hits: BLAST: gb:AAB89060.1; (AE000954) conserved hypothetical protein; E=7e-11 gb:AAD23399.1; AF110772_1 (AF110772) unknown [Streptomyces; E=1e-10 pir:G69054; conserved hypothetical protein MTH141 - Methanobacterium; E=1e-10 COG: AF2196; COG1891 Uncharacterized ArCR; E=7e-12.
 
   
 0.782
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
 
     0.781
fwdC-2
Tungsten formylmethanofuran dehydrogenase, subunit C (fwdC); PMID: 8575452 best DB hits: BLAST: gb:AAB89324.1; (AE000970) tungsten formylmethanofuran; E=2e-17 pir:T45154; probable formylmethanofuran dehydrogenase (EC 1.2.99.5); E=3e-17 swissprot:Q59579; FWDC_METTM TUNGSTEN-CONTAINING; E=2e-14 COG: AF1931; COG2218 Formylmethanofuran dehydrogenase subunit C; E=2e-18 TM0394; COG0070 Glutamate synthetase domain 3; E=2e-06 MJ0658; COG2218 Formylmethanofuran dehydrogenase subunit C; E=0.001 PFAM: PF01493; Domain of unknown function DUF14; E=1.3e-06.
 
     0.781
RB10299
Conserved hypothetical protein; PMID: 9651254 PMID: 10215859 PMID: 10848995 PMID: 11073907 best DB hits: BLAST: gb:AAC27021.1; (AF032114) unknown [Methylobacterium extorquens]; E=0.029 embl:CAB92281.1; (AL356595) hypothetical protein [Streptomyces; E=0.43 pir:C83094; D-alanine--D-alanine ligase PA4410 [imported] -; E=0.62 PFAM: PF00826; Ribosomal L10; E=0.66.
 
     0.778
RB10246
Conserved hypothetical protein; PMID: 9651254 PMID: 10215859 PMID: 10848995 PMID: 11073907 best DB hits: BLAST: gb:AAG32953.1; (AF032114) unknown [Methylobacterium extorquens]; E=2e-21 pir:D69199; conserved hypothetical protein MTH743 - Methanobacterium; E=6e-18 swissprot:Q57680; Y227_METJA HYPOTHETICAL PROTEIN MJ0227 -----; E=2e-16 COG: MTH743; COG1767 Uncharacterized ACR; E=5e-19 PFAM: PF01874; CitG family; E=1.9e-07.
 
     0.775
fae
Probable D-arabino 3-hexulose 6-phosphate formaldehyde lyase (hps-2); Best DB hits: BLAST: gb:AAB89943.1; (AE001014) D-arabino 3-hexulose 6-phosphate; E=4e-41 pir:D69063; conserved hypothetical protein MTH1474 -; E=2e-40 gb:AAG32954.1; (AF032114) formaldehyde-activating enzyme; E=1e-37 COG: AF1305_1; COG1795 Uncharacterized archaeal domain; E=4e-42.
  
     0.775
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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