Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
glcEPMID: 8606183 best DB hits: BLAST: pir:H65083; glycolate oxidase subunits GlcE and GlcF - Escherichia; E=6e-23 swissprot:P52073; GLCE_ECOLI GLYCOLATE OXIDASE SUBUNIT GLCE; E=6e-23 pir:D82977; glycolate oxidase subunit GlcE PA5354 [imported] -; E=1e-22 COG: glcF_1; COG0277 FAD/FMN-containing dehydrogenases; E=6e-24 PFAM: PF01565; FAD binding domain; E=6.6e-19. (410 aa)    
Predicted Functional Partners:
glcD
Glycolate oxidase subunit GlcD; PMID: 8606183 PMID: 11283302 best DB hits: BLAST: pir:E82977; glycolate oxidase subunit GlcD PA5355 [imported] -; E=1e-102 pir:S74338; glycolate oxidase chain glcD - Synechocystis sp. (strain; E=1e-101 swissprot:P52075; GLCD_ECOLI GLYCOLATE OXIDASE SUBUNIT GLCD; E=1e-99 COG: PA5355; COG0277 FAD/FMN-containing dehydrogenases; E=1e-103 PFAM: PF01565; FAD binding domain; E=2.7e-55 PF02913; FAD linked oxidases, C-terminal; E=7.9e-53.
  
  0.995
glcF
PMID: 8606183 best DB hits: BLAST: pir:G75361; glycolate oxidase, iron-sulfur subunit - Deinococcus; E=1e-101 pir:S75231; (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) - Synechocystis; E=3e-62 ddbj:BAB05854.1; (AP001514) glycolate oxidase iron-sulfur subunit; E=2e-58 COG: DR1730; COG0247 Fe-S oxidoreductases; E=1e-102 PFAM: PF00037; 4Fe-4S binding domain; E=0.21 PF02754; Domain of unknown function (DUF2; E=4.9e-07.
 
 
 0.995
RB6394
Probable 2-hydroxyacid dehydrogenase; PMID: 10984043 best DB hits: BLAST: gb:AAH00605.1; AAH00605 (BC000605) glyoxylate; E=1e-66 ref:XP_005487.2; glyoxylate reductasehydroxypyruvate reductase; E=1e-66 gb:AAF51963.1; (AE003602) CG1236 gene product [Drosophila; E=7e-61 COG: APE1831; COG1052 Lactate dehydrogenase and related dehydrogenases; E=2e-60 PAB0514; COG0111 Phosphoglycerate dehydrogenase and related; E=3e-44 YNL274c; COG1052 Lactate dehydrogenase and related dehydrogenases; E=3e-34 PFAM: PF00389; D-isomer specific 2-hydroxyacid; E=2.4e-06 PF02826; D-isomer specific 2-hydroxyacid; [...]
 
 
 0.926
RB2754
Conserved hypothetical protein-putative phosphoglycolate phosphatase; PMID: 9371463 PMID: 7603433 best DB hits: BLAST: pir:E69106; hypothetical protein MTH1793 - Methanobacterium; E=3e-05 pir:T44528; phosphoglycolate phosphatase (EC 3.1.3.18) [imported] -; E=3e-04 gb:AAG42459.1; AF308467_5 (AF308467) Gph [Klebsiella aerogenes]; E=3e-04 COG: MTH1793; COG0546 Predicted phosphatases; E=3e-06 PFAM: PF00702; haloacid dehalogenase-like hydrolas; E=1.1e-16.
    
 0.907
RB12038
Best DB hits: BLAST: ddbj:BAB04429.1; (AP001509) BH0710~unknown conserved protein; E=8e-91 pir:T34927; probable oxidoreductase - Streptomyces coelicolor; E=5e-84 embl:CAB88965.1; (AL353864) putative oxidoreductase; E=3e-46 COG: BH0710; COG0673 Predicted dehydrogenases and related proteins; E=7e-92 PFAM: PF01408; Oxidoreductase family, NAD-bin; E=7e-36 PF02894; Oxidoreductase family, C-termi; E=6.8e-06.
  
    0.773
RB12043
Hypothetical protein.
       0.773
RB5701
Putative oxidase; PMID: 3286606 best DB hits: BLAST: gb:AAG20509.1; (AE005123) glycolate oxidase subunit; GlcD; E=2e-48 gb:AAG20148.1; (AE005092) glycerol-3-phosphate dehydrogenase chain; E=5e-40 gb:AAG56674.1; AE005391_11 (AE005391) putative oxidase; E=2e-38 COG: VNG2422G_1; COG0277 FAD/FMN-containing dehydrogenases; E=2e-49 VNG2422G_2; COG0247 Fe-S oxidoreductases; E=7e-42 ydiJ_1; COG0277 FAD/FMN-containing dehydrogenases; E=5e-39 PFAM: PF01565; FAD binding domain; E=6.7e-40 PF02913; FAD linked oxidases, C-terminal; E=2.6e-14.
 
  
 0.576
RB12035
Hypothetical protein.
       0.506
RB12047
Putative ATP-dependent RNA helicase rhlE; PMID: 8037924 PMID: 9278503 PMID: 8905232 PMID: 1931833 best DB hits: BLAST: swissprot:P25888; RHLE_ECOLI PUTATIVE ATP-DEPENDENT RNA HELICASE; E=5e-78 gb:AAG55168.1; AE005260_7 (AE005260) putative ATP-dependent RNA; E=5e-78 pir:D83591; probable ATP-dependent RNA helicase PA0428 [imported] -; E=8e-77 COG: rhlE; COG0513 Superfamily II DNA and RNA helicases; E=4e-79 PFAM: PF00270; DEAD/DEAH box helicase; E=5.5e-70 PF02776; Thiamine pyrophosphate enzyme,; E=0.21 PF00271; Helicase conserved C-terminal d; E=3.5e-36.
   
   0.493
RB12046
Hypothetical protein.
       0.468
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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