STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB12047Putative ATP-dependent RNA helicase rhlE; PMID: 8037924 PMID: 9278503 PMID: 8905232 PMID: 1931833 best DB hits: BLAST: swissprot:P25888; RHLE_ECOLI PUTATIVE ATP-DEPENDENT RNA HELICASE; E=5e-78 gb:AAG55168.1; AE005260_7 (AE005260) putative ATP-dependent RNA; E=5e-78 pir:D83591; probable ATP-dependent RNA helicase PA0428 [imported] -; E=8e-77 COG: rhlE; COG0513 Superfamily II DNA and RNA helicases; E=4e-79 PFAM: PF00270; DEAD/DEAH box helicase; E=5.5e-70 PF02776; Thiamine pyrophosphate enzyme,; E=0.21 PF00271; Helicase conserved C-terminal d; E=3.5e-36. (485 aa)    
Predicted Functional Partners:
nnrE
Conserved hypothetical protein; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.
   
 0.898
RbgA
Predicted GTPase; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
  
 0.889
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.887
rplX
Probable 50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
   
 
 0.864
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 
 0.853
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
 0.831
rplO
50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
 
 0.830
pnp-2
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
 
 0.823
thiD
PMID: 10075431 best DB hits: BLAST: pir:E71057; probable thiamin biosynthesis protein - Pyrococcus; E=4e-45 pir:C75087; hydroxymethylpyrimidine phosphate kinase (thid) PAB1646; E=2e-44 pir:F75613; phosphomethylpyrimidine kinase - Deinococcus radiodurans; E=5e-43 COG: PH1155_1; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine; E=4e-46 thiD; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; E=3e-42 NMB1616; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine; E=3e-41 PFAM: PF01031; Dynamin central region; E=0.41 PF00294; pfkB family carbohydrate kinase; E=7.7e-08.
 
 
    0.816
rpsE
30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
   
 0.799
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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