STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepACytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (507 aa)    
Predicted Functional Partners:
RB4485
Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
  
  
  0.914
aspC
Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147.
    
 0.842
glyA
Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.832
cysM
Cysteine synthase B; PMID: 2188958 best DB hits: BLAST: swissprot:P16703; CYSM_ECOLI CYSTEINE SYNTHASE B (O-ACETYLSERINE; E=1e-30 pir:D82758; cysteine synthase XF0831 [imported] - Xylella fastidiosa; E=1e-30 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=2e-30 COG: cysM; COG0031 Cysteine synthase; E=1e-31 PFAM: PF00291; Pyridoxal-phosphate dependent enzyme; E=5.9e-51.
    
 0.820
cysK
Cysteine synthase (O-acetylserine sulfhydrylase); PMID: 10930739 best DB hits: BLAST: gb:AAG01804.1; AF276772_3 (AF276772) O-acetylserine sulfhydrylase; E=3e-83 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=1e-82 pir:H81161; probable cysteine synthase (EC 4.2.99.8) NMA0974; E=1e-81 COG: Rv2334; COG0031 Cysteine synthase; E=1e-83 PFAM: PF00291; Pyridoxal-phosphate dependent enzym; E=1.3e-119.
    
 0.820
metB-2
Cystathionine gamma-lyase homolog; PMID: 9843488 best DB hits: BLAST: pir:T45483; cystathionine gamma-lyase homolog [imported] -; E=9e-93 pir:F83595; probable cystathionine gamma-lyase PA0400 [imported] -; E=1e-92 gb:AAG19548.1; (AE005045) cystathionine alpha synthase; MetB; E=3e-92 COG: PA0400; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-93 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=2.9e-199.
   
 
  0.800
RB12108
Probable response regulatory protein (atoC); PMID: 9665876 PMID: 8346225 best DB hits: BLAST: ddbj:BAB06667.1; (AP001517) two-component response regulator in; E=2e-87 pir:F71315; probable response regulatory protein (atoC) - syphilis; E=1e-85 gb:AAF33506.1; (AF170176) Salmonella typhimurium transcriptional; E=5e-83 COG: BH2948; COG2204 AAA superfamily ATPases with N-terminal receiver; E=2e-88 aq_218_2; COG1221 NtrC family transcriptional regulators, ATPase; E=1e-66 CT468; COG2204 AAA superfamily ATPases with N-terminal receiver; E=5e-66 PFAM: PF00072; Response regulator receiver doma; [...]
       0.608
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
     0.497
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.467
RB12110
Hypothetical protein.
       0.412
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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