STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
carBPMID: 8905231 PMID: 6308632 best DB hits: BLAST: swissprot:P00968; CARB_ECOLI CARBAMOYL-PHOSPHATE SYNTHASE LARGE; E=0.0 pir:S76557; carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC; E=0.0 gb:AAG10606.1; AC008030_6 (AC008030) carbamoyl phosphate synthetase; E=0.0 COG: AF1274; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 carB; COG0458 Carbamoylphosphate synthase large subunit (split gene in; E=0.0 BU144; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 PFAM: PF00289; Carbamoyl-phosphate synthase L; E=2.9e-53 PF02222; ATP-grasp domain; E [...] (1083 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase, catalytic subunit (pyrB); PMID: 6364131 PMID: 6302686 PMID: 6341995 PMID: 10318893 PMID: 2271529 best DB hits: BLAST: gb:AAB91125.1; (AE001099) aspartate carbamoyltransferase,; E=3e-31 swissprot:P96174; PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE; E=7e-30 embl:CAC11715.1; (AL445064) probable aspartate; E=2e-29 COG: AF0106; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=2e-32 AF1255; COG0078 Ornithine carbamoyltransferase; E=2e-10 PFAM: PF02729; Aspartate/ornithine carbamoyltransfe; E=3.6e-20 PF00185; Aspartate/ornithine carbamoyltransfe; E=3e-0 [...]
 
 0.999
carA
Carbamoyl-phosphate synthase, small chain; PMID: 2843375 PMID: 6330744 best DB hits: BLAST: pir:E82083; carbamoyl-phosphate synthase, small chain VC2390; E=1e-99 pir:C70337; carbamoyl phosphate synthetase small subunit - Aquifex; E=3e-98 pir:S76783; hypothetical protein - Synechocystis sp. (strain PCC; E=6e-96 COG: VC2390; COG0505 Carbamoylphosphate synthase small subunit; E=1e-100 PFAM: PF00988; Carbamoyl-phosphate synthase; E=8.7e-82 PF00117; Glutamine amidotransferase cl; E=5.7e-62; Belongs to the CarA family.
 0.999
pyrB-2
Aspartate carbamoyltransferase; PMID: 97000351 best DB hits: BLAST: embl:CAB93367.1; (AL357523) aspartate carbamoyltransferase; E=4e-67 swissprot:P74163; PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE; E=6e-64 swissprot:Q59711; PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE; E=5e-63 COG: slr1476; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=6e-65 PFAM: PF02729; Aspartate/ornithine carbamoylt; E=1.1e-44 PF01229; Glycosyl hydrolases family 39; E=0.23 PF00185; Aspartate/ornithine carbamoylt; E=7.1e-18; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 0.999
argG
Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190.
 
 
 0.994
pyrC
Dihydroorotase; PMID: 7516791 best DB hits: BLAST: pir:D82736; dihydroorotase XF0988 [imported] - Xylella fastidiosa; E=1e-86 pir:B82954; probable dihydroorotase PA5541 [imported] - Pseudomonas; E=2e-72 swissprot:O27199; PYRC_METTH DIHYDROOROTASE (DHOASE) -----; E=7e-51 COG: XF0988; COG0044 Dihydroorotase; E=9e-88 PFAM: PF02612; N-acetylglucosamine-6-phosphat; E=3.6e-06 PF00744; Dihydroorotase-like; E=2.4e-72.
 
 0.989
purF
Amidophosphoribosyltransferase [precursor]; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.987
argF
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
 
 0.975
pfaS
PMID: 10548741 best DB hits: BLAST: gb:AAB89983.1; (AE001017) phosphoribosylformylglycinamidine; E=2e-33 ddbj:BAA20816.1; (AB002359) KIAA0361 [Homo sapiens]; E=2e-26 swissprot:O15067; PUR4_HUMAN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE; E=2e-26 COG: AF1260; COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase,; E=1e-34 NMB1996_2; COG0047 Phosphoribosylformylglycinamidine (FGAM); E=3e-22 HI0752_2; COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase,; E=1e-20.
 
 
 0.966
gltB
Glutamate synthase [NADPH] large chain; PMID: 2643092 PMID: 3326786 best DB hits: BLAST: swissprot:Q06434; GLSF_ANTSP FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE; E=0.0 swissprot:P23225; GLSF_MAIZE FERREDOXIN-DEPENDENT GLUTAMATE; E=0.0 swissprot:Q03460; GLSN_MEDSA GLUTAMATE SYNTHASE [NADH], CHLOROPLAST; E=0.0 COG: sll1502_2; COG0069 Glutamate synthetase domain 2; E=0.0 sll1502_1; COG0067 Glutamate synthetase domain 1; E=1e-118 PFAM: PF01645; Conserved region in glutamate; E=5.5e-235 PF01493; Domain of unknown function DU; E=4.2e-95.
  
 
 0.963
pyrF
Orotidine 5-phosphate decarboxylase; PMID: 8787418 best DB hits: BLAST: swissprot:P96076; DCOP_THETH OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; E=3e-38 pir:G75302; orotidine 5'-phosphate decarboxylase - Deinococcus; E=5e-35 gb:AAG19923.1; (AE005076) orotidine-5'-monophosphate (Ura3); PyrF; E=4e-33 COG: DR2200_2; COG0284 Orotidine-5'-phosphate decarboxylase; E=1e-35; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
  
 0.962
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.