STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pntBNAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (453 aa)    
Predicted Functional Partners:
RB12291
Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10.
 
 0.999
pntA
NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: prf:2102322A; energy-transducing nicotinamide nucleotide; E=8e-76 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=9e-74 gb:AAK00588.1; (AY026033) pyridine nucleotide transhydrogenase; E=1e-72 COG: slr1239; COG3288 NAD/NADP transhydrogenase alpha subunit; E=9e-75 BH2329; COG0686 Alanine dehydrogenase; E=4e-26 PFAM: PF01266; D-amino acid oxidase; E=0.05 PF00070; Pyridine nucleotide-disulphide oxid; E=0.00011 PF01262; Alanine dehydrogenase/pyridine nucl; E=5.4e-89.
 0.999
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.931
nadK
Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
     
 0.911
sthA
PMID: 9922271 best DB hits: BLAST: swissprot:P27306; STHA_ECOLI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-154 swissprot:Q9XBQ9; STHA_AZOVI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-149 swissprot:P50529; STHA_VIBCH SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-146 COG: VC0151; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-147 PFAM: PF00070; Pyridine nucleotide-disulphide; E=6.5e-63 PF02852; Pyridine nucleotide-disulphide; E=1.6e-34.
     
 0.906
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.902
cobT
Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
    
  0.900
ald
Alanine dehydrogenase; PMID: 10473410 best DB hits: BLAST: gb:AAC23578.1; (AF070715) alanine dehydrogenase [Shewanella sp; E=2e-97 pir:JE0388; alanine dehydrogenase (EC 1.4.1.1) - Enterobacter; E=1e-96 swissprot:P30234; DHA_MYCTU ALANINE DEHYDROGENASE (40 KDA ANTIGEN); E=5e-96 COG: Rv2780; COG0686 Alanine dehydrogenase; E=5e-97 pntA; COG3288 NAD/NADP transhydrogenase alpha subunit; E=4e-21 PFAM: PF01262; Alanine dehydrogenase/pyridine nucl; E=1.6e-147; Belongs to the AlaDH/PNT family.
      0.862
RB12295
Hypothetical protein.
       0.460
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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