node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RB12291 | RB12295 | RB12291 | RB12295 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | Hypothetical protein. | 0.460 |
RB12291 | cobT | RB12291 | RB8404 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | 0.905 |
RB12291 | nadD | RB12291 | RB8455 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.904 |
RB12291 | nadE | RB12291 | RB5671 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.906 |
RB12291 | nadK | RB12291 | RB2142 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.914 |
RB12291 | pntA | RB12291 | RB12292 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: prf:2102322A; energy-transducing nicotinamide nucleotide; E=8e-76 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=9e-74 gb:AAK00588.1; (AY026033) pyridine nucleotide transhydrogenase; E=1e-72 COG: slr1239; COG3288 NAD/NADP transhydrogenase alpha subunit; E=9e-75 BH2329; COG0686 Alanine dehydrogenase; E=4e-26 PFAM: PF01266; D-amino acid oxidase; E=0.05 PF00070; Pyridine nucleotide-disulphide oxid; E=0.00011 PF01262; Alanine dehydrogenase/pyridine nucl; E=5.4e-89. | 0.992 |
RB12291 | pntB | RB12291 | RB12290 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |
RB12291 | rpoC | RB12291 | RB5416 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.542 |
RB12291 | sthA | RB12291 | RB5717 | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | PMID: 9922271 best DB hits: BLAST: swissprot:P27306; STHA_ECOLI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-154 swissprot:Q9XBQ9; STHA_AZOVI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-149 swissprot:P50529; STHA_VIBCH SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-146 COG: VC0151; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-147 PFAM: PF00070; Pyridine nucleotide-disulphide; E=6.5e-63 PF02852; Pyridine nucleotide-disulphide; E=1.6e-34. | 0.902 |
RB12295 | RB12291 | RB12295 | RB12291 | Hypothetical protein. | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | 0.460 |
RB12295 | pntA | RB12295 | RB12292 | Hypothetical protein. | NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: prf:2102322A; energy-transducing nicotinamide nucleotide; E=8e-76 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=9e-74 gb:AAK00588.1; (AY026033) pyridine nucleotide transhydrogenase; E=1e-72 COG: slr1239; COG3288 NAD/NADP transhydrogenase alpha subunit; E=9e-75 BH2329; COG0686 Alanine dehydrogenase; E=4e-26 PFAM: PF01266; D-amino acid oxidase; E=0.05 PF00070; Pyridine nucleotide-disulphide oxid; E=0.00011 PF01262; Alanine dehydrogenase/pyridine nucl; E=5.4e-89. | 0.524 |
RB12295 | pntB | RB12295 | RB12290 | Hypothetical protein. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.460 |
cobT | RB12291 | RB8404 | RB12291 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | 0.905 |
cobT | nadD | RB8404 | RB8455 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.932 |
cobT | nadE | RB8404 | RB5671 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.943 |
cobT | nadK | RB8404 | RB2142 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.922 |
cobT | pntA | RB8404 | RB12292 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: prf:2102322A; energy-transducing nicotinamide nucleotide; E=8e-76 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=9e-74 gb:AAK00588.1; (AY026033) pyridine nucleotide transhydrogenase; E=1e-72 COG: slr1239; COG3288 NAD/NADP transhydrogenase alpha subunit; E=9e-75 BH2329; COG0686 Alanine dehydrogenase; E=4e-26 PFAM: PF01266; D-amino acid oxidase; E=0.05 PF00070; Pyridine nucleotide-disulphide oxid; E=0.00011 PF01262; Alanine dehydrogenase/pyridine nucl; E=5.4e-89. | 0.905 |
cobT | pntB | RB8404 | RB12290 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
cobT | sthA | RB8404 | RB5717 | Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | PMID: 9922271 best DB hits: BLAST: swissprot:P27306; STHA_ECOLI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-154 swissprot:Q9XBQ9; STHA_AZOVI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-149 swissprot:P50529; STHA_VIBCH SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-146 COG: VC0151; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-147 PFAM: PF00070; Pyridine nucleotide-disulphide; E=6.5e-63 PF02852; Pyridine nucleotide-disulphide; E=1.6e-34. | 0.908 |
nadD | RB12291 | RB8455 | RB12291 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10. | 0.904 |