STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (245 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.943
nrdA
Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity).
  
 
 0.941
tdk
Thymidine kinase Tdk; PMID: 2060797 PMID: 2041474 best DB hits: BLAST: gb:AAK03320.1; (AE006163) Tdk [Pasteurella multocida]; E=2e-66 swissprot:P44309; KITH_HAEIN THYMIDINE KINASE -----pir:; E=3e-65 swissprot:P23331; KITH_ECOLI THYMIDINE KINASE ----- pir:; E=2e-64 COG: HI0529; COG1435 Thymidine kinase; E=3e-66 PFAM: PF00265; Thymidine kinase; E=4.9e-88.
  
 
 0.937
ndk
Nucleoside diphosphate kinase (NDK); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.931
surE
Acid phosphatase SurE; PMID: 8905231 best DB hits: BLAST: swissprot:P73440; YE59_SYNY3 HYPOTHETICAL 24.9 KD PROTEIN SLL1459; E=4e-31 swissprot:O83434; SURE_TREPA STATIONARY-PHASE SURVIVAL PROTEIN; E=3e-22 gb:AAD51394.1; AF117715_3 (AF117715) survival protein homolog; E=4e-20 COG: sll1459; COG0496 Survival protein, predicted acid phosphatase; E=4e-32 PFAM: PF01975; Survival protein SurE; E=9.8e-49.
    
 0.912
surE-2
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.912
RB1703
Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
  
 
  0.907
nagD
N-acetylglucosamine-6-phoshatase or p-nitrophenyl phosphatase; PMID: 97000351 PMID: 99411980 PMID: 2668691 PMID: 2190615 best DB hits: BLAST: embl:CAB65573.1; (AL136058) probable; E=1e-51 ddbj:BAB07147.1; (AP001518) p-nitrophenyl phosphatase [Bacillus; E=4e-43 swissprot:P15302; NAGD_ECOLI NAGD PROTEIN ----- pir: B64802; E=6e-42 COG: BH3428; COG0647 Predicted sugar phosphatases of the HAD superfamily; E=4e-44 VNG0719G; COG0647 Predicted sugar phosphatases of the HAD; E=7e-31 BH1074; COG0647 Predicted sugar phosphatases of the HAD superfamily; E=2e-24 PFAM: PF00702; haloacid dehalogenase [...]
   
 
  0.901
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.791
RB12444
Hypothetical protein-transmembrane prediction.
       0.773
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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