STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB12611Probable methyltransferase; Best DB hits: BLAST: pir:S75267; hypothetical protein slr1039 - Synechocystis sp. (strain; E=5e-07 swissprot:P46326; YXBB_BACSU HYPOTHETICAL 28.2 KDA PROTEIN IN; E=7e-06 gb:AAG29793.1; AF235050_16 (AF235050) putative methyltransferase; E=0.005 COG: slr1039; COG0500 SAM-dependent methyltransferases; E=5e-08 VC1257; COG2227; E=9e-04 BH2331; COG0500 SAM-dependent methyltransferases; E=0.001. (275 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
    0.774
RB12610
Hypothetical protein.
       0.773
RB12612
Hypothetical protein.
       0.773
RB12718
Conserved hypothetical protein-putative tRNA adenylyltransferase; PMID: 10910347 best DB hits: BLAST: gb:AAK00328.1; AF320250_1 (AF320250) YmdA [Lactobacillus; E=0.029 pir:F82689; tRNA adenylyltransferase XF1362 [imported] - Xylella; E=0.044 pir:D71218; hypothetical protein PH0007 - Pyrococcus horikoshii; E=0.054 COG: XF1362; COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; E=0.004 PH0007; COG2413 Uncharacterized ACR; E=0.005 PFAM: PF01966; HD domain; E=0.0033.
  
     0.608
RB12608
Uncharacterized protein; PMID: 10984043 best DB hits: BLAST: pir:D83367; hypothetical protein PA2235 [imported] - Pseudomonas; E=0.002 swissprot:P33698; EXOP_RHIME SUCCINOGLYCAN BIOSYNTHESIS TRANSPORT; E=0.010 pir:S37031; probable succinoglycan transport protein exoP -; E=0.021 COG: PA2235; COG3206 Uncharacterized protein involved in; E=2e-04.
       0.572
RB1250
PMID: 10984043 best DB hits: BLAST: pir:B83188; probable permease of ABC transporter PA3671 [imported] -; E=7e-21 pir:B83142; hypothetical protein PA4038 [imported] - Pseudomonas; E=3e-17 pir:H70193; membrane spanning protein homolog - Lyme disease; E=1e-12 COG: PA3671; COG1277 Permease component of an ABC-transporter; E=6e-22 PA4039; COG3225 Uncharacterized BCR; E=1e-04 PH1531; COG1668 ATP-dependent Na+ efflux pump membrane component; E=0.002.
  
     0.559
RB13038
Conserved hypothetical protein-putative transglutaminase-like enzyme; PMID: 10452618 best DB hits: BLAST: pir:D75012; hypothetical protein PAB1274 - Pyrococcus abyssi (strain; E=3e-04 gb:AAB91268.1; (AE001110) A. fulgidus predicted coding region; E=0.006 pir:F70464; hypothetical protein aq_1912 - Aquifex aeolicus -----; E=0.011 COG: PAB1274_1; COG1305 Transglutaminase-like enzymes, putative cysteine; E=4e-04 PFAM: PF02553; Cobalt transport protein compo; E=0.37 PF01841; Transglutaminase-like superfam; E=0.00013.
  
     0.550
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.528
RB5128
Conserved hypothetical protein; PMID: 10984043 best DB hits: BLAST: pir:B83386; hypothetical protein PA2078 [imported] - Pseudomonas; E=7e-14 swissprot:P55493; Y4IJ_RHISN HYPOTHETICAL 65.5 KD PROTEIN Y4IJ; E=2e-13 swissprot:P55496; Y4IM_RHISN HYPOTHETICAL 47.1 KD PROTEIN Y4IM; E=1e-11 PFAM: PF00034; Cytochrome c; E=0.064.
  
     0.515
RB1972
Conserved hypothetical protein; PMID: 9384377 best DB hits: BLAST: pir:A70029; hypothetical protein yvaX - Bacillus subtilis -----; E=4e-04 swissprot:Q90805; CNG1_CHICK CYCLIC NUCLEOTIDE GATED CHANNEL, CONE; E=0.52.
  
   
 0.497
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.