STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Experiments
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[Homology]
Score
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (195 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.999
purU
Formyltetrahydrofolate deformylase; PMID: 7868604 best DB hits: BLAST: gb:AAG20130.1; (AE005091) formyltetrahydrofolate deformylase; E=5e-24 swissprot:Q55135; PURU_SYNY3 FORMYLTETRAHYDROFOLATE DEFORMYLASE; E=3e-17 pir:C82633; formyltetrahydrofolate deformylase XF1831 [imported] -; E=2e-15 COG: VNG1946G; COG0788 Formyltetrahydrofolate hydrolase; E=5e-25 TM1248; COG0299 Folate-dependent phosphoribosylglycinamide; E=2e-07 Rv2964; COG0788 Formyltetrahydrofolate hydrolase; E=8e-07 PFAM: PF00551; Formyl transferase; E=1.4e-10.
    
 0.960
glyA
Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.937
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.935
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.932
folC
PMID: 10360571 best DB hits: BLAST: pir:D72411; folylpolyglutamate synthasedihydrofolate synthase -; E=4e-40 ddbj:BAB06756.1; (AP001517) folyl-polyglutamate synthetase; E=8e-39 swissprot:Q05865; FOLC_BACSU FOLYLPOLYGLUTAMATE SYNTHASE; E=8e-38 COG: TM0166; COG0285 Folylpolyglutamate synthase; E=4e-41 PFAM: PF01225; Mur ligase family, catalytic dom; E=1.6e-13 PF02875; Mur ligase family, glutamate lig; E=0.00031.
     
 0.929
purH
Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113.
    
 0.924
pur3
Phosphoribosylglycinamide formyltransferase; PMID: 95004650 best DB hits: BLAST: embl:CAA52779.2; (X74767) phosphoribosylglycinamide; E=1e-25 swissprot:P52422; PUR3_ARATH PHOSPHORIBOSYLGLYCINAMIDE; E=1e-25 pir:T11574; phosphoribosylglycinamide formyltransferase (EC 2.1.2.2); E=2e-25 COG: aq_857; COG0299 Folate-dependent phosphoribosylglycinamide; E=1e-23 VC1992; COG0788 Formyltetrahydrofolate hydrolase; E=9e-12 Cj0187c; COG0299 Folate-dependent phosphoribosylglycinamide; E=4e-11 PFAM: PF00551; Formyl transferase; E=2.9e-41.
   
 
 0.924
gcvT
Probable aminotransferase-glycine cleavage system T protein; PMID: 8165246 best DB hits: BLAST: swissprot:O86567; GCST_STRCO PROBABLE AMINOMETHYLTRANSFERASE; E=6e-67 swissprot:P54378; GCST_BACSU PROBABLE AMINOMETHYLTRANSFERASE; E=1e-61 swissprot:Q9K934; GCST_BACHD PROBABLE AMINOMETHYLTRANSFERASE; E=2e-59 COG: BS_yqhI; COG0404 Glycine cleavage system T protein; E=1e-62 PFAM: PF01571; Glycine cleavage T-protein (aminomet; E=7.5e-102.
  
 
 0.923
RB3854
Conserved hypothetical protein; PMID: 10952301 best DB hits: BLAST: pir:D82278; hypothetical protein VC0802 [imported] - Vibrio cholerae; E=2e-24 pir:C83100; hypothetical protein PA4364 [imported] - Pseudomonas; E=3e-15.
 
      0.630
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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