Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RB12646Probable histidine kinase; PMID: 8282725 best DB hits: BLAST: embl:CAB54579.1; (AJ006397) histidine kinase [Streptococcus; E=2e-10 gb:AAG59311.1; AE005644_5 (AE005644) sensor protein for basR; E=6e-10 pir:E83212; probable sensorresponse regulator hybrid PA3462; E=3e-09 COG: PA3462; COG0642 Sensory transduction histidine kinases; E=3e-10 PFAM: PF00512; His Kinase A (phosphoacceptor); E=2.1e-10 PF02518; Histidine kinase-, DNA gyrase B; E=6.2e-15. (497 aa)    
Predicted Functional Partners:
RB10488
PMID: 20572072 best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=3e-67 pir:E83443; probable sensorresponse regulator hybrid PA1611; E=2e-64 pir:H82211; sensory box sensor histidine kinaseresponse regulator; E=8e-61 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=7e-62 PFAM: PF00785; PAC motif; E=0.00076 PF00512; His Kinase A (phosphoacceptor) d; E=1.6e-28 PF02518; Histidine kinase-, DNA gyrase B-; E=1.6e-42.
 
 
 0.945
RB641
Sensory histidine protein kinase; Best DB hits: BLAST: pir:G82753; two-component system, sensor protein XF0853 [imported] -; E=2e-41 gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=8e-39 pir:A82300; sensory box sensor histidine kinaseresponse regulator; E=4e-34 COG: XF0853; COG0642 Sensory transduction histidine kinases; E=2e-42 sll0779_1; COG2202 PAS/PAC domain; E=1e-23 VCA0736_1; COG0642 Sensory transduction histidine kinases; E=1e-23 PFAM: PF00785; PAC motif; E=8.5e-08 PF00989; PAS domain; E=0.013 PF00785; PAC motif; E=0.1.
 
 
 0.942
RB12326
Sensory histidine protein kinase; PMID: 11406410 best DB hits: BLAST: gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=2e-45 pir:F83153; probable two-component sensor PA3946 [imported] -; E=3e-36 pir:E83265; probable two-component sensor PA3044 [imported] -; E=2e-35 COG: PA3044; COG0642 Sensory transduction histidine kinases; E=2e-36 PFAM: PF01590; GAF domain; E=3.2e-20 PF00989; PAS domain; E=1.2e-07 PF00512; His Kinase A (phosphoacceptor) d; E=4.8e-16.
 
 
 
 0.858
RB3373
PMID: 9098081 best DB hits: BLAST: pir:T28655; receptor-like histidine kinase BpdS - Rhodococcus sp; E=1e-60 pir:T30898; receptor-like histidine kinase - Rhodococcus erythropolis; E=1e-60 pir:S75136; sensory transduction histidine kinase slr2104 -; E=9e-58 COG: VC1349_2; COG0642 Sensory transduction histidine kinases; E=1e-41 PFAM: PF00069; Protein kinase domain; E=8.1e-08 PF00515; TPR Domain; E=0.026 PF00512; His Kinase A (phosphoacceptor); E=1.4e-21.
 
 
0.835
RB11986
Histidine protein kinase homolog GacS; PMID: 10762268 best DB hits: BLAST: gb:AAF04854.1; AF197912_1 (AF197912) histidine protein kinase; E=3e-57 pir:E83212; probable sensorresponse regulator hybrid PA3462; E=4e-56 pir:H83132; probable sensorresponse regulator hybrid PA4112; E=8e-51 COG: PA3462; COG0642 Sensory transduction histidine kinases; E=3e-57 PFAM: PF00989; PAS domain; E=3.5e-07 PF00512; His Kinase A (phosphoacceptor; E=2.5e-21 PF02518; Histidine kinase-, DNA gyrase; E=6.8e-39.
  
 
   0.803
RB6217
Putative response regulator; PMID: 10376842 best DB hits: BLAST: gb:AAD28578.1; AF121341_2 (AF121341) putative response regulator; E=7e-27 gb:AAA87378.1; (L42554) pleD gene product [Caulobacter; E=3e-21 pir:S74913; sensory transduction system regulatory protein slr1400 -; E=4e-21 COG: slr1400_1; COG0784 CheY-like receiver domains; E=4e-20 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-19 VC0622_4; COG0784 CheY-like receiver domains; E=4e-19 PFAM: PF00072; Response regulator receiver doma; E=3.1e-37.
  
   0.789
RB5478
Putative two-component system response regulator; PMID: 7699720 best DB hits: BLAST: embl:CAB88489.1; (AL353816) putative two-component systen; E=1e-15 gb:AAB06615.1; (U53173) MviA [Salmonella typhimurium]; E=2e-14 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=1e-13 COG: slr0115; COG0745 Response regulators consisting of a CheY-like; E=1e-13 XF1952_3; COG0784 CheY-like receiver domains; E=3e-13 Rv0981; COG0745 Response regulators consisting of a CheY-like; E=3e-12 PFAM: PF00072; Response regulator receiver doma; E=2.4e-27.
  
   0.780
RB2728
PMID: 8552028 best DB hits: BLAST: pir:D82244; sensory box sensor histidine kinase VC1084 [imported] -; E=4e-15 ddbj:BAB05639.1; (AP001513) two-component sensor histidine kinase; E=1e-13 pir:S60595; FixL protein - Rhizobium leguminosarum ----- gb:; E=3e-13 COG: VC1084; COG0642 Sensory transduction histidine kinases; E=3e-16 PFAM: PF00672; HAMP domain; E=2.9e-10 PF00512; His Kinase A (phosphoacceptor) doma; E=3.2e-08 PF02518; Histidine kinase-, DNA gyrase B-, p; E=7.9e-33.
  
 
   0.777
RB5472
Probable two-component system response regulator; PMID: 1454550 best DB hits: BLAST: embl:CAB94653.1; (AL359215) putative two-component system; E=3e-12 pir:D72374; response regulator - Thermotoga maritima (strain MSB8); E=2e-11 embl:CAC04498.1; (AL391588) putative two-component system; E=5e-11 COG: TM0468; COG0784 CheY-like receiver domains; E=2e-12 BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=3e-11 slr0322_3; COG0784 CheY-like receiver domains; E=3e-10 PFAM: PF00072; Response regulator receiver doma; E=9.1e-23.
  
   0.766
hydH-3
Sensor protein HYDH; PMID: 2666400 best DB hits: BLAST: swissprot:P14377; HYDH_ECOLI SENSOR PROTEIN HYDH ----- pir:; E=5e-19 gb:AAG59200.1; AE005632_1 (AE005632) sensor kinase for HydG,; E=6e-18 swissprot:P07168; VIRA_AGRT6 WIDE HOST RANGE VIRA PROTEIN (WHR; E=6e-18 COG: hydH; COG0642 Sensory transduction histidine kinases; E=5e-20 PFAM: PF00512; His Kinase A (phosphoacceptor) doma; E=1.1e-06 PF02518; Histidine kinase-, DNA gyrase B-, p; E=4e-35.
  
     0.754
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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