STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuA3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (511 aa)    
Predicted Functional Partners:
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 0.999
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.999
leuB-2
3-isopropylmalate dehydrogenase; PMID: 3110742 best DB hits: BLAST: pir:D75045; 3-isopropylmalate dehydrogenase (leub) PAB2424 -; E=2e-52 swissprot:O66607; LEU3_AQUAE 3-ISOPROPYLMALATE DEHYDROGENASE; E=6e-51 swissprot:Q9WZ26; LEU3_THEMA 3-ISOPROPYLMALATE DEHYDROGENASE; E=2e-49 COG: PAB2424; COG0473 Isocitrate/isopropylmalate dehydrogenase; E=2e-53 PFAM: PF00180; Isocitrate and isopropylmalate dehyd; E=6.3e-108 PF02376; CUT domain; E=0.32.
 0.998
leuA-2
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 0.997
leuA-3
2-isopropylmalate synthase; PMID: 6171647 best DB hits: BLAST: swissprot:O66682; LY41_AQUAE PUTATIVE LYASE AQ_356 ----- pir:; E=1e-132 pir:E75045; 2-isopropylmalate synthase (leua-3) PAB0894 - Pyrococcus; E=1e-130 swissprot:Q9WZ22; LY41_THEMA PUTATIVE LYASE TM0552 ----- pir:; E=1e-124 COG: aq_356; COG0119 Isopropylmalate/homocitrate/citramalate synthases; E=1e-133 PFAM: PF00682; HMGL-like; E=6.6e-09; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.988
ilvC
Acetohydroxy acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.975
ilvN
Probable acetolactate synthase small subunit; PMID: 6308579 PMID: 1851954 best DB hits: BLAST: swissprot:O27492; ILVH_METTH PROBABLE ACETOLACTATE SYNTHASE SMALL; E=1e-27 pir:S74358; acetolactate synthase ilvN - Synechocystis sp. (strain; E=5e-27 gb:AAB89532.1; (AE000985) acetolactate synthase, small subunit; E=9e-27 COG: MTH1443; COG0440 Acetolactate synthase, small subunit; E=9e-29 PFAM: PF01842; ACT domain; E=1.1e-18.
  
  
 0.919
ldh
L-lactate dehydrogenase; PMID: 3122782 PMID: 3118900 best DB hits: BLAST: swissprot:P00345; LDH_BACME L-LACTATE DEHYDROGENASE -----pir:; E=3e-49 swissprot:P20619; LDHX_BACPS L-LACTATE DEHYDROGENASE X -----; E=6e-47 swissprot:P16115; LDH_THEMA L-LACTATE DEHYDROGENASE ----- pir:; E=3e-46 COG: TM1867; COG0039 Malate/lactate dehydrogenases; E=2e-47 PFAM: PF00056; lactate/malate dehydrogenase, NA; E=6.7e-46 PF02866; lactate/malate dehydrogenase, al; E=2.4e-36; Belongs to the LDH/MDH superfamily.
  
 
 0.817
ldh-2
L-lactate/malate dehydrogenase; PMID: 8404889 PMID: 3098260 best DB hits: BLAST: swissprot:P16115; LDH_THEMA L-LACTATE DEHYDROGENASE -----pir:; E=2e-51 pdb:1A5Z; Lactate Dehydrogenase From Thermotoga Maritima; E=2e-51 pdb:1LLC; L-Lactate Dehydrogenase (E.C.1.1.1.27) Complex With; E=9e-49 COG: TM1867; COG0039 Malate/lactate dehydrogenases; E=2e-52 PFAM: PF00056; lactate/malate dehydrogenase, NA; E=7.5e-36 PF02866; lactate/malate dehydrogenase, al; E=5e-36; Belongs to the LDH/MDH superfamily.
  
 
 0.817
ldhA
PMID: 9025293 best DB hits: BLAST: pir:D83529; D-lactate dehydrogenase (fermentative) PA0927 [imported]; E=3e-95 pir:S76782; D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) -; E=1e-91 swissprot:P52643; LDHD_ECOLI D-LACTATE DEHYDROGENASE (D-LDH); E=1e-86 COG: PA0927; COG1052 Lactate dehydrogenase and related dehydrogenases; E=3e-96 PAB0514; COG0111 Phosphoglycerate dehydrogenase and related; E=3e-37 TP0037; COG1052 Lactate dehydrogenase and related dehydrogenases; E=5e-37 PFAM: PF00389; D-isomer specific 2-hydroxyacid; E=1.4e-24 PF02891; MIZ zinc finger; E=0.34 PF02826; D-isomer specific 2 [...]
    
 0.814
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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