Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pilCType IV fimbrial assembly protein PilC; PMID: 1971619 best DB hits: BLAST: pir:A75344; pilin biogenesis protein - Deinococcus radiodurans; E=7e-48 swissprot:P22609; PILC_PSEAE FIMBRIAL ASSEMBLY PROTEIN PILC; E=7e-44 pir:C83078; still frameshift type 4 fimbrial biogenesis protein PilC; E=3e-41 COG: DR1863; COG1459 General secretory pathway protein F; E=6e-49 PFAM: PF00482; Bacterial type II secretion system p; E=1.2e-68. (479 aa)    
Predicted Functional Partners:
pilB-2
Type IV fimbrial assembly protein PilB; PMID: 1971619 best DB hits: BLAST: pir:C75333; general secretion pathway protein E - Deinococcus; E=1e-105 pir:B70469; type IV pilus assembly protein TapB - Aquifex aeolicus; E=1e-104 swissprot:P45792; TAPB_AERHY TYPE IV PILUS ASSEMBLY PROTEIN TAPB; E=1e-100 COG: DR1964; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=1e-107 PFAM: PF00005; ABC transporter; E=0.27 PF00448; SRP54-type protein, GTPase doma; E=0.01 PF00004; ATPase family associated with v; E=0.0029.
 
 
 0.967
pilT-2
Twitching mobility protein PilT; PMID: 1676385 best DB hits: BLAST: pir:C70365; twitching motility protein PilT - Aquifex aeolicus; E=7e-81 pir:B75333; twitching mobility protein - Deinococcus radiodurans; E=9e-81 embl:CAB56295.1; (AJ249385) twitching motility protein; E=2e-77 COG: aq_745; COG2805 Predicted ATPases involved in pili biogenesis, PilT; E=6e-82 TM0837; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=4e-27 PFAM: PF00437; Bacterial type II secretion syst; E=0.18 PF02283; Cobinamide kinase / cobinamide p; E=0.86 PF00437; Bacterial type II secretion syst; E=1.5e-51.
 
  
 0.942
pilB
Type IV fimbrial assembly protein PilB; PMID: 1971619 PMID: 1944223 best DB hits: BLAST: pir:E72032; general secretion pathway protein E CP1055 [imported] -; E=6e-91 embl:CAA70956.1; (Y09824) etpE [Escherichia coli]; E=2e-93 gb:AAC70102.1; (AF074613) type II secretion protein [Escherichia; E=6e-94 COG: slr0063; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=1e-81 PFAM: PF00004; ATPase family associated with variou; E=0.0009 PF00005; ABC transporter; E=0.074 PF00448; SRP54-type protein, GTPase domain; E=0.01.
 
 
 0.880
hofB
PMID: 9537320 best DB hits: BLAST: pir:B70428; general secretion pathway protein E - Aquifex aeolicus; E=7e-21 pir:C75333; general secretion pathway protein E - Deinococcus; E=6e-19 pir:C83313; probable type II secretion protein PA2677 [imported] -; E=1e-18 COG: aq_1474; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=6e-22 PFAM: PF00437; Bacterial type II secretion system p; E=0.00098.
  
   0.861
RB11595
PMID: 1944223 best DB hits: BLAST: pir:C75333; general secretion pathway protein E - Deinococcus; E=6e-98 pir:E72032; general secretion pathway protein E CP1055 [imported] -; E=4e-89 pir:D71499; probable gen. secretion protein E - Chlamydia; E=1e-88 COG: DR1964; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=5e-99 PFAM: PF00437; Bacterial type II secretion system p; E=1.3e-138.
  
   0.861
gspE
PMID: 1588814 best DB hits: BLAST: pir:C75333; general secretion pathway protein E - Deinococcus; E=1e-44 swissprot:P37093; GSPE_VIBCH GENERAL SECRETION PATHWAY PROTEIN E; E=6e-44 pir:C83313; probable type II secretion protein PA2677 [imported] -; E=3e-43 COG: DR1964; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=1e-45 PFAM: PF00437; Bacterial type II secretion s; E=5.5e-12 PF00448; SRP54-type protein, GTPase do; E=0.15 PF00437; Bacterial type II secretion s; E=5.5e-52.
  
   0.861
RB3482
General secretion pathway protein E; PMID: 1944223 best DB hits: BLAST: pir:D82672; general secretory pathway protein E XF1517 [imported] -; E=1e-114 swissprot:P31742; GSPE_XANCP GENERAL SECRETION PATHWAY PROTEIN E; E=1e-110 pir:T12056; xpsE protein - Xanthomonas campestris pv. campestris; E=1e-110 COG: XF1517; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=1e-115 PFAM: PF00004; ATPase family associated with variou; E=0.13 PF00448; SRP54-type protein, GTPase domain; E=0.038 PF00437; Bacterial type II secretion system p; E=8.8e-156.
  
   0.861
RB2860
PMID: 10567266 best DB hits: BLAST: pir:C75477; probable fimbrial assembly protein PilM - Deinococcus; E=1e-19 gb:AAK00347.1; AF329876_3 (AF329876) putative membrane protein; E=1e-06 pir:S75816; membrane protein pilM - Synechocystis sp. (strain PCC; E=8e-06 COG: DR0770; COG0849 Predicted ATPases of the HSP70 class involved in; E=1e-20.
 
 
 
 0.835
RB8494
Best DB hits: BLAST: pir:A75321; prepilin peptidase, type IV - Deinococcus radiodurans; E=4e-16 swissprot:P72640; LEP4_SYNY3 TYPE 4 PREPILIN-LIKE PROTEINS LEADER; E=3e-15 ddbj:BAA83726.1; (AB017809) prepilin peptidase [Escherichia coli]; E=3e-14 COG: DR2065; COG1989 Signal peptidase, cleaves prepilin-like proteins; E=4e-17 PFAM: PF01478; Type III leader peptidase famil; E=8.9e-28.
 
  
 0.828
pilT
Twitching motility protein PilT; PMID: 8100347 PMID: 1676385 best DB hits: BLAST: pir:F82321; twitching motility protein PilT VC0462 [imported] -; E=2e-65 pir:C70365; twitching motility protein PilT - Aquifex aeolicus; E=1e-63 swissprot:P24559; PILT_PSEAE TWITCHING MOBILITY PROTEIN -----; E=3e-61 COG: VC0462; COG2805 Predicted ATPases involved in pili biogenesis, PilT; E=1e-66 XF1517; COG2804 Predicted ATPases involved in pili biogenesis, PilB; E=2e-22 PFAM: PF00155; Aminotransferase class-I; E=0.3 PF00448; SRP54-type protein, GTPase do; E=0.32 PF00437; Bacterial type II secretion s; E [...]
 
  
 0.783
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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