Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
aspCAspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147. (397 aa)    
Predicted Functional Partners:
gdhA
Glutamate dehydrogenase A; PMID: 7551585 best DB hits: BLAST: swissprot:O04937; DHEA_NICPL GLUTAMATE DEHYDROGENASE A (GDH A); E=1e-115 swissprot:Q43314; DHE1_ARATH GLUTAMATE DEHYDROGENASE 1 (GDH 1); E=1e-115 pir:T04342; glutamate dehydrogenase (EC 1.4.1.2) - maize -----; E=1e-114 COG: TM1015; COG0334 Glutamate dehydrogenase/leucine dehydrogenase; E=1e-99 PFAM: PF02812; Glu/Leu/Phe/Val dehydrogenase; E=3.1e-56 PF00044; Glyceraldehyde 3-phosphate de; E=0.76 PF02254; KTN NAD-binding domain; E=0.33; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.950
ldh
L-lactate dehydrogenase; PMID: 3122782 PMID: 3118900 best DB hits: BLAST: swissprot:P00345; LDH_BACME L-LACTATE DEHYDROGENASE -----pir:; E=3e-49 swissprot:P20619; LDHX_BACPS L-LACTATE DEHYDROGENASE X -----; E=6e-47 swissprot:P16115; LDH_THEMA L-LACTATE DEHYDROGENASE ----- pir:; E=3e-46 COG: TM1867; COG0039 Malate/lactate dehydrogenases; E=2e-47 PFAM: PF00056; lactate/malate dehydrogenase, NA; E=6.7e-46 PF02866; lactate/malate dehydrogenase, al; E=2.4e-36; Belongs to the LDH/MDH superfamily.
   
 0.938
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
   
 0.938
ldh-2
L-lactate/malate dehydrogenase; PMID: 8404889 PMID: 3098260 best DB hits: BLAST: swissprot:P16115; LDH_THEMA L-LACTATE DEHYDROGENASE -----pir:; E=2e-51 pdb:1A5Z; Lactate Dehydrogenase From Thermotoga Maritima; E=2e-51 pdb:1LLC; L-Lactate Dehydrogenase (E.C.1.1.1.27) Complex With; E=9e-49 COG: TM1867; COG0039 Malate/lactate dehydrogenases; E=2e-52 PFAM: PF00056; lactate/malate dehydrogenase, NA; E=7.5e-36 PF02866; lactate/malate dehydrogenase, al; E=5e-36; Belongs to the LDH/MDH superfamily.
   
 0.938
putA
PMID: 96062224 best DB hits: BLAST: pir:H64526; proline dehydrogenase (EC 1.5.99.8); E=0.0 pir:B71980; proline dehydrogenase (EC 1.5.99.8); E=0.0 pir:C81297; proline dehydrogenase (EC 1.5.99.8); E=1e-180 COG: jhp0048_2; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-123 Cj1503c_1; COG0506 Proline dehydrogenase; E=2e-56 sll1561_2; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-51 PFAM: PF01619; Proline dehydrogenase; E=2e-36 PF00171; Aldehyde dehydrogenase family; E=0.0014; Belongs to the aldehyde dehydrogenase family.
   
 0.935
pheA
P-protein (PheA); PMID: 1919506 best DB hits: BLAST: swissprot:O67085; PHEA_AQUAE P-PROTEIN [INCLUDES: CHORISMATE; E=2e-40 swissprot:P27603; PHEA_PSEST P-PROTEIN [INCLUDES: CHORISMATE; E=8e-40 gb:AAD47360.1; AF038578_3 (AF038578) chorismate mutaseprephenate; E=1e-38 COG: aq_951_2; COG0077 Prephenate dehydratase; E=9e-40 PFAM: PF00800; Prephenate dehydratase; E=4.5e-50 PF01842; ACT domain; E=3.1e-09.
    
 0.935
hisC
Histidinol-phosphate aminotransferase; PMID: 1400209 best DB hits: BLAST: swissprot:P73807; HIS8_SYNY3 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=1e-56 swissprot:P45358; HIS8_ACEXY HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=2e-52 gb:AAK00147.1; AF222753_2 (AF222753) putative aminotransferase; E=2e-43 COG: sll1958; COG0079 Histidinol-phosphate aminotransferase/Tyrosine; E=1e-57 PFAM: PF00155; Aminotransferase class-I; E=5.1e-06 PF00222; Aminotransferase class-II; E=1.3e-17; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase s [...]
   
 
 0.930
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.919
argG
Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190.
   
 
 0.918
gltA
Citrate synthase; PMID: 2337600 PMID: 6380576 best DB hits: BLAST: gb:AAF04133.1; AF191033_1 (AF191033) citrate synthase; E=1e-152 embl:CAB66275.1; (AL136519) citrate synthase. [Streptomyces; E=1e-149 swissprot:Q10530; CISY_MYCTU CITRATE SYNTHASE 1 ----- pir:; E=1e-145 COG: Rv0896; COG0372 Citrate synthase; E=1e-146 PFAM: PF00285; Citrate synthase; E=1e-208.
   
 0.915
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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