STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tktTransketolase; PMID: 7859749 best DB hits: BLAST: swissprot:P45694; TKT_BACSU TRANSKETOLASE ----- pir: G69723; E=1e-171 ddbj:BAB06071.1; (AP001515) transketolase [Bacillus halodurans]; E=1e-169 swissprot:Q43848; TKTC_SOLTU TRANSKETOLASE, CHLOROPLAST PRECURSOR; E=1e-164 COG: BS_tkt; COG0021 Transketolase; E=1e-172 PFAM: PF00456; Transketolase, thiamine dipho; E=1.1e-160 PF02779; Transketolase, central domain; E=1.2e-77 PF02780; Transketolase, C-terminal dom; E=1.1e-49; Belongs to the transketolase family. (683 aa)    
Predicted Functional Partners:
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
 
 0.999
rpe
Ribulose-phosphate 3-epimerase; PMID: 10625676 best DB hits: BLAST: pir:G82052; ribulose-phosphate 3-epimerase VC2625 [imported] -; E=1e-42 gb:AAK03703.1; (AE006199) Dod [Pasteurella multocida]; E=1e-40 gb:AAF01048.1; AF189365_1 (AF189365) D-ribulose-5-phosphate; E=3e-40 COG: VC2625; COG0036 Pentose-5-phosphate-3-epimerase; E=1e-43 PFAM: PF00834; Ribulose-phosphate 3 epimerase; E=1.8e-85.
 0.990
pgi
Glucose-6-phosphate isomerase; PMID: 2549364 best DB hits: BLAST: swissprot:P80860; G6PI_BACSU GLUCOSE-6-PHOSPHATE ISOMERASE (GPI); E=6e-53 ddbj:BAB07062.1; (AP001518) glucose-6-phosphate isomerase; E=4e-52 pir:S15937; glucose-6-phosphate isomerase (EC 5.3.1.9) - Bacillus; E=5e-52 COG: BS_pgi; COG0166 Glucose-6-phosphate isomerase; E=6e-54 PFAM: PF00342; Phosphoglucose isomerase; E=6.8e-31.
  
 0.984
fba
Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.969
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 
 0.957
RB2627
Glyceraldehyde 3-phosphate dehydrogenase; PMID: 8557349 best DB hits: BLAST: swissprot:O06822; G3P_MYCTU GLYCERALDEHYDE 3-PHOSPHATE; E=2e-99 swissprot:P46795; G3P_BORBU GLYCERALDEHYDE 3-PHOSPHATE; E=2e-99 swissprot:P46713; G3P_MYCLE GLYCERALDEHYDE 3-PHOSPHATE; E=6e-99 COG: Rv1436; COG0057 Glyceraldehyde-3-phosphate; E=1e-101 PFAM: PF01408; Oxidoreductase family, NAD-bindi; E=0.11 PF00044; Glyceraldehyde 3-phosphate dehyd; E=2.2e-118 PF02800; Glyceraldehyde 3-phosphate dehyd; E=5.5e-109; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
 
 0.948
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
  
 0.942
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 0.942
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
  
 0.936
fbaB
Fructose-bisphosphate aldolase class I; PMID: 9531482 best DB hits: BLAST: pir:H64976; hypothetical protein b2097 - Escherichia coli (strain; E=1e-119 swissprot:P71295; ALF1_ECOLI FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS; E=1e-119 gb:AAB18249.1; (U73760) dehydrin [Escherichia coli]; E=1e-117 COG: fbaB; COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and; E=1e-120.
  
 
 0.932
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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