STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (437 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.996
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.991
purH
Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113.
  
 0.984
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
  
  
 0.946
hpt
Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...]
  
 
 0.942
argG
Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190.
  
 
 0.934
guaA-2
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.925
aspC
Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147.
  
 0.923
pyrB
Aspartate carbamoyltransferase, catalytic subunit (pyrB); PMID: 6364131 PMID: 6302686 PMID: 6341995 PMID: 10318893 PMID: 2271529 best DB hits: BLAST: gb:AAB91125.1; (AE001099) aspartate carbamoyltransferase,; E=3e-31 swissprot:P96174; PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE; E=7e-30 embl:CAC11715.1; (AL445064) probable aspartate; E=2e-29 COG: AF0106; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=2e-32 AF1255; COG0078 Ornithine carbamoyltransferase; E=2e-10 PFAM: PF02729; Aspartate/ornithine carbamoyltransfe; E=3.6e-20 PF00185; Aspartate/ornithine carbamoyltransfe; E=3e-0 [...]
  
 
 0.920
pyrB-2
Aspartate carbamoyltransferase; PMID: 97000351 best DB hits: BLAST: embl:CAB93367.1; (AL357523) aspartate carbamoyltransferase; E=4e-67 swissprot:P74163; PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE; E=6e-64 swissprot:Q59711; PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE; E=5e-63 COG: slr1476; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=6e-65 PFAM: PF02729; Aspartate/ornithine carbamoylt; E=1.1e-44 PF01229; Glycosyl hydrolases family 39; E=0.23 PF00185; Aspartate/ornithine carbamoylt; E=7.1e-18; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.920
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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