| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RB5134 | guaB | RB5134 | RB11822 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.923 |
| RB5134 | hpt | RB5134 | RB6524 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | 0.903 |
| RB5134 | purA | RB5134 | RB12924 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.949 |
| RB5134 | purH | RB5134 | RB10113 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113. | 0.922 |
| guaB | RB5134 | RB11822 | RB5134 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.923 |
| guaB | hpt | RB11822 | RB6524 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | 0.944 |
| guaB | pur3 | RB11822 | RB7260 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylglycinamide formyltransferase; PMID: 95004650 best DB hits: BLAST: embl:CAA52779.2; (X74767) phosphoribosylglycinamide; E=1e-25 swissprot:P52422; PUR3_ARATH PHOSPHORIBOSYLGLYCINAMIDE; E=1e-25 pir:T11574; phosphoribosylglycinamide formyltransferase (EC 2.1.2.2); E=2e-25 COG: aq_857; COG0299 Folate-dependent phosphoribosylglycinamide; E=1e-23 VC1992; COG0788 Formyltetrahydrofolate hydrolase; E=9e-12 Cj0187c; COG0299 Folate-dependent phosphoribosylglycinamide; E=4e-11 PFAM: PF00551; Formyl transferase; E=2.9e-41. | 0.497 |
| guaB | purA | RB11822 | RB12924 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.989 |
| guaB | purB | RB11822 | RB8343 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.877 |
| guaB | purC | RB11822 | RB12194 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PMID: 10710307 PMID: 8828210 best DB hits: BLAST: ddbj:BAA89448.1; (AB003161); E=3e-61 pir:G81943; probable phosphoribosylaminoimidazolesuccinocarboxamide; E=4e-60 pir:B81161; phosphoribosylaminoimidazole-succinocarboxamide synthase; E=1e-59 COG: NMB0757; COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide; E=1e-60 PFAM: PF01259; SAICAR synthetase; E=2.3e-21. | 0.607 |
| guaB | purE | RB11822 | RB6135 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase catalytic subunit (air carboxylase) (airc); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.651 |
| guaB | purH | RB11822 | RB10113 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113. | 0.993 |
| guaB | purK | RB11822 | RB6133 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.927 |
| guaB | purL | RB11822 | RB5395 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.767 |
| hpt | RB5134 | RB6524 | RB5134 | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.903 |
| hpt | guaB | RB6524 | RB11822 | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.944 |
| hpt | purA | RB6524 | RB12924 | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
| hpt | purB | RB6524 | RB8343 | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.405 |
| hpt | purH | RB6524 | RB10113 | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113. | 0.936 |
| hpt | purL | RB6524 | RB5395 | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.458 |
