node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argG | aspC | RB8293 | RB12864 | Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. | Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147. | 0.920 |
argG | purA | RB8293 | RB12924 | Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.934 |
argG | purL | RB8293 | RB5395 | Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.432 |
argG | pyrB | RB8293 | RB13301 | Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. | Aspartate carbamoyltransferase, catalytic subunit (pyrB); PMID: 6364131 PMID: 6302686 PMID: 6341995 PMID: 10318893 PMID: 2271529 best DB hits: BLAST: gb:AAB91125.1; (AE001099) aspartate carbamoyltransferase,; E=3e-31 swissprot:P96174; PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE; E=7e-30 embl:CAC11715.1; (AL445064) probable aspartate; E=2e-29 COG: AF0106; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=2e-32 AF1255; COG0078 Ornithine carbamoyltransferase; E=2e-10 PFAM: PF02729; Aspartate/ornithine carbamoyltransfe; E=3.6e-20 PF00185; Aspartate/ornithine carbamoyltransfe; E=3e-0 [...] | 0.902 |
argG | pyrB-2 | RB8293 | RB7429 | Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. | Aspartate carbamoyltransferase; PMID: 97000351 best DB hits: BLAST: embl:CAB93367.1; (AL357523) aspartate carbamoyltransferase; E=4e-67 swissprot:P74163; PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE; E=6e-64 swissprot:Q59711; PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE; E=5e-63 COG: slr1476; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=6e-65 PFAM: PF02729; Aspartate/ornithine carbamoylt; E=1.1e-44 PF01229; Glycosyl hydrolases family 39; E=0.23 PF00185; Aspartate/ornithine carbamoylt; E=7.1e-18; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.902 |
aspC | argG | RB12864 | RB8293 | Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147. | Argininosuccinate synthase; PMID: 20158877 PMID: 90046714 PMID: 3174461 best DB hits: BLAST: pir:H72210; argininosuccinate synthase - Thermotoga maritima (strain; E=2e-97 pir:D75490; arginosuccinate synthase - Deinococcus radiodurans; E=3e-96 pir:C83204; argininosuccinate synthase PA3525 [imported] -; E=2e-87 COG: TM1780; COG0137 Argininosuccinate synthase; E=2e-98 PFAM: PF00764; Arginosuccinate synthase; E=2e-190. | 0.920 |
aspC | purA | RB12864 | RB12924 | Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.923 |
aspC | pyrB | RB12864 | RB13301 | Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147. | Aspartate carbamoyltransferase, catalytic subunit (pyrB); PMID: 6364131 PMID: 6302686 PMID: 6341995 PMID: 10318893 PMID: 2271529 best DB hits: BLAST: gb:AAB91125.1; (AE001099) aspartate carbamoyltransferase,; E=3e-31 swissprot:P96174; PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE; E=7e-30 embl:CAC11715.1; (AL445064) probable aspartate; E=2e-29 COG: AF0106; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=2e-32 AF1255; COG0078 Ornithine carbamoyltransferase; E=2e-10 PFAM: PF02729; Aspartate/ornithine carbamoyltransfe; E=3.6e-20 PF00185; Aspartate/ornithine carbamoyltransfe; E=3e-0 [...] | 0.900 |
aspC | pyrB-2 | RB12864 | RB7429 | Aspartate aminotransferase; PMID: 6378205 best DB hits: BLAST: swissprot:P44425; AAT_HAEIN ASPARTATE AMINOTRANSFERASE; E=1e-114 swissprot:P00509; AAT_ECOLI ASPARTATE AMINOTRANSFERASE; E=1e-112 pdb:1ART; Aspartate Aminotransferase (E.C.2.6.1.1) Complexed; E=1e-112 COG: HI1617; COG1448 Aspartate/aromatic aminotransferase; E=1e-115 PH1371; COG0436 PLP-dependent aminotransferases; E=1e-04 PFAM: PF00155; Aminotransferase class-I; E=1e-147. | Aspartate carbamoyltransferase; PMID: 97000351 best DB hits: BLAST: embl:CAB93367.1; (AL357523) aspartate carbamoyltransferase; E=4e-67 swissprot:P74163; PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE; E=6e-64 swissprot:Q59711; PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE; E=5e-63 COG: slr1476; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=6e-65 PFAM: PF02729; Aspartate/ornithine carbamoylt; E=1.1e-44 PF01229; Glycosyl hydrolases family 39; E=0.23 PF00185; Aspartate/ornithine carbamoylt; E=7.1e-18; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.900 |
guaA-2 | guaB | RB8374 | RB11822 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA-2 | hpt | RB8374 | RB6524 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | 0.948 |
guaA-2 | purA | RB8374 | RB12924 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.925 |
guaA-2 | purB | RB8374 | RB8343 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.887 |
guaA-2 | purH | RB8374 | RB10113 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113. | 0.885 |
guaA-2 | purL | RB8374 | RB5395 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.937 |
guaA-2 | pyrB | RB8374 | RB13301 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aspartate carbamoyltransferase, catalytic subunit (pyrB); PMID: 6364131 PMID: 6302686 PMID: 6341995 PMID: 10318893 PMID: 2271529 best DB hits: BLAST: gb:AAB91125.1; (AE001099) aspartate carbamoyltransferase,; E=3e-31 swissprot:P96174; PYRB_VIBS2 ASPARTATE CARBAMOYLTRANSFERASE; E=7e-30 embl:CAC11715.1; (AL445064) probable aspartate; E=2e-29 COG: AF0106; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=2e-32 AF1255; COG0078 Ornithine carbamoyltransferase; E=2e-10 PFAM: PF02729; Aspartate/ornithine carbamoyltransfe; E=3.6e-20 PF00185; Aspartate/ornithine carbamoyltransfe; E=3e-0 [...] | 0.602 |
guaA-2 | pyrB-2 | RB8374 | RB7429 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aspartate carbamoyltransferase; PMID: 97000351 best DB hits: BLAST: embl:CAB93367.1; (AL357523) aspartate carbamoyltransferase; E=4e-67 swissprot:P74163; PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE; E=6e-64 swissprot:Q59711; PYRB_PSEPU ASPARTATE CARBAMOYLTRANSFERASE; E=5e-63 COG: slr1476; COG0540 Aspartate carbamoyltransferase, catalytic chain; E=6e-65 PFAM: PF02729; Aspartate/ornithine carbamoylt; E=1.1e-44 PF01229; Glycosyl hydrolases family 39; E=0.23 PF00185; Aspartate/ornithine carbamoylt; E=7.1e-18; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.577 |
guaB | guaA-2 | RB11822 | RB8374 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | hpt | RB11822 | RB6524 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...] | 0.944 |
guaB | purA | RB11822 | RB12924 | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.991 |