Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RB12952Two-component system, regulatory protein; PMID: 7699720 best DB hits: BLAST: pir:D83083; probable two-component response regulator PA4493; E=8e-30 gb:AAF87208.1; AF228577_2 (AF228577) ActR [Rhizobium leguminosarum; E=8e-30 swissprot:Q52913; ACTR_RHIME ACID TOLERANCE REGULATORY PROTEIN; E=1e-29 COG: PA4493; COG0784 CheY-like receiver domains; E=8e-31 TP0519; COG2204 AAA superfamily ATPases with N-terminal receiver; E=3e-12 BH3787; COG0784 CheY-like receiver domains; E=8e-11 PFAM: PF00072; Response regulator receiver doma; E=2.9e-25. (221 aa)    
Predicted Functional Partners:
RB12949
Histidine protein kinase; PMID: 8757734 best DB hits: BLAST: gb:AAB38420.1; (L39938) histidine protein kinase [Sinorhizobium; E=2e-16 pir:E83083; probable two-component sensor PA4494 [imported] -; E=3e-16 gb:AAA93222.1; (U22925) RegB [Rhodobacter sphaeroides]; E=2e-12 COG: PA4494; COG0642 Sensory transduction histidine kinases; E=2e-17 PFAM: PF00512; His Kinase A (phosphoacceptor; E=0.011 PF02518; Histidine kinase-, DNA gyrase; E=1.2e-28.
 
 0.988
RB10330
Best DB hits: BLAST: pir:S75136; sensory transduction histidine kinase slr2104 -; E=3e-69 pir:E83443; probable sensorresponse regulator hybrid PA1611; E=2e-56 pir:H83132; probable sensorresponse regulator hybrid PA4112; E=1e-52 COG: PA4982; COG0642 Sensory transduction histidine kinases; E=4e-49 PFAM: PF00512; His Kinase A (phosphoacceptor) d; E=1.3e-22 PF02518; Histidine kinase-, DNA gyrase B-; E=8e-46 PF00072; Response regulator receiver doma; E=6.2e-33.
 
 
 
 0.772
RB12326
Sensory histidine protein kinase; PMID: 11406410 best DB hits: BLAST: gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=2e-45 pir:F83153; probable two-component sensor PA3946 [imported] -; E=3e-36 pir:E83265; probable two-component sensor PA3044 [imported] -; E=2e-35 COG: PA3044; COG0642 Sensory transduction histidine kinases; E=2e-36 PFAM: PF01590; GAF domain; E=3.2e-20 PF00989; PAS domain; E=1.2e-07 PF00512; His Kinase A (phosphoacceptor) d; E=4.8e-16.
 
 
 0.771
RB4511
Sensory transduction histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
  
 
 0.760
RB12942
Hypothetical protein-transmembrane prediction.
     
 0.700
RB641
Sensory histidine protein kinase; Best DB hits: BLAST: pir:G82753; two-component system, sensor protein XF0853 [imported] -; E=2e-41 gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=8e-39 pir:A82300; sensory box sensor histidine kinaseresponse regulator; E=4e-34 COG: XF0853; COG0642 Sensory transduction histidine kinases; E=2e-42 sll0779_1; COG2202 PAS/PAC domain; E=1e-23 VCA0736_1; COG0642 Sensory transduction histidine kinases; E=1e-23 PFAM: PF00785; PAC motif; E=8.5e-08 PF00989; PAS domain; E=0.013 PF00785; PAC motif; E=0.1.
 
 
 0.676
hydH
Sensor kinase of the HydH/G two-component system; PMID: 2666400 PMID: 11243806 best DB hits: BLAST: gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=2e-23 gb:AAG09417.1; AF180147_9 (AF180147) bZIP histidine kinase TobS; E=5e-23 embl:CAB43735.1; (Y18245) bZIP histidine kinase [Pseudomonas; E=6e-23 COG: BH1920; COG0642 Sensory transduction histidine kinases; E=2e-22 PFAM: PF00072; Response regulator receiver doma; E=1.2e-21 PF00989; PAS domain; E=1e-08 PF00785; PAC motif; E=0.053.
 
   
 0.634
ntrC-2
Probable nitrogen regulation protein; PMID: 2882477 best DB hits: BLAST: pir:H70558; hypothetical protein Rv1626 - Mycobacterium tuberculosis; E=3e-16 pir:T35758; probable response regulator - Streptomyces coelicolor; E=4e-15 pir:S52249; response regulator nasT - Azotobacter vinelandii -----; E=1e-12 COG: Rv1626; COG0784 CheY-like receiver domains; E=2e-17 glnG; COG2204 AAA superfamily ATPases with N-terminal receiver; E=3e-06 MTH447_1; COG0784 CheY-like receiver domains; E=2e-04 PFAM: PF00072; Response regulator receiver doma; E=0.0018.
      
 0.618
RB13122
Hypothetical protein.
      
 0.618
RB138
Hypothetical protein.
      
 0.618
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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